Multiscale modelling: Applications to the Biomedical Sciences. 1) Significant reductions in the costs of developing pharmaceutical treatments, 2) Substantial reduction in hospitalisation costs, 3) Improved treatment of wounds, a significant cause of chronic ill-health which presently costs the Australian HealthCare System A$500,000,000/year.
Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficie ....Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficient by providing a valuable experimental interpretive tool and a theoretical map for material optimization. Our models will also provide crucial information needed for modelling the behavior of composites in applications.Read moreRead less
Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent exp ....Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent explosions in reactors and storage tanks. Other potential applications range from bushfires to the manufacture of exotic materials. Furthermore, the novel mathematical techniques developed in this project can be easily adapted to other types of systems such as those used in biology (eg. epidemiology and tumour growth), economics, physics etc. Read moreRead less
Special Research Initiatives - Grant ID: SR0354623
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Network for Australian security technologies integration. The frontline of community safety is security technologies which include sensors to track movements and conversations of suspects; signal processing techniques for extracting information; intelligent search/audit techniques to track financial transactions; analysis techniques for predicting the spread of epidemic; and above all human factors in security operations. The aim of this initiative is to establish a network for "safeguarding Aus ....Network for Australian security technologies integration. The frontline of community safety is security technologies which include sensors to track movements and conversations of suspects; signal processing techniques for extracting information; intelligent search/audit techniques to track financial transactions; analysis techniques for predicting the spread of epidemic; and above all human factors in security operations. The aim of this initiative is to establish a network for "safeguarding Australia". This network, built on the concept of "network of networks", draws on the expertise of researchers and practitioners from diverse fields to provide an integrated approach towards development and use of security technologies for the safety of the community.Read moreRead less
Digital Imagery for Building 3D City Models. The project will investigate the application of digital photogrammetric imagery, and primarily high-resolution satellite imagery for the creation of visually realistic 3D city models. Virtual reality computer models of urban scenes find application in urban planning, facilities management, engineering and even virtual tourism. Building upon recently initiated collaborative research, the project aims to develop improved methods and procedures for autom ....Digital Imagery for Building 3D City Models. The project will investigate the application of digital photogrammetric imagery, and primarily high-resolution satellite imagery for the creation of visually realistic 3D city models. Virtual reality computer models of urban scenes find application in urban planning, facilities management, engineering and even virtual tourism. Building upon recently initiated collaborative research, the project aims to develop improved methods and procedures for automated, image-based object reconstruction to support the generation of metrically accurate 3D computer models of buildings and the built environment.Read moreRead less
Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will en ....Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will enhance Australia's reputation in this cutting edge research, and contribute to achieving optimal performance of high commercial and environmental value applications. It will also facilitate international collaboration, and provide an excellent opportunity for research training.Read moreRead less
Nonlocal Statistical Mechanics and Logarithmic Conformal Field Theory. Australia has an enviable track record as an innovator and developer of advanced materials. This project in strategic basic research consists of theoretical work within the disciplines of statistical mechanics and conformal field theory to determine the profound role of nonlocal interactions, such as connectivities, in determining the critical physical properties of materials. Connectivities play a significant role in diverse ....Nonlocal Statistical Mechanics and Logarithmic Conformal Field Theory. Australia has an enviable track record as an innovator and developer of advanced materials. This project in strategic basic research consists of theoretical work within the disciplines of statistical mechanics and conformal field theory to determine the profound role of nonlocal interactions, such as connectivities, in determining the critical physical properties of materials. Connectivities play a significant role in diverse applications such as the gelation of polymers, random fuse networks, the spatial spread of epidemics and bushfires and the tertiary recovery of oil. This research will be practically useful in engineering the physical properties of advanced materials such as liquid crystals, gels, polymers and other materials.Read moreRead less
Exact solution of generalized models of polymers and percolation in two dimensions. Originating with the work of Rodney Baxter, Australia is the world leader in exactly solvable lattice models in two dimensions. This project, in strategic basic research, aims to continue this tradition and extend it by solving exactly new classes of two-dimensional lattice models involving nonlocal degrees of freedom. Since this will lead to new universal classes of thermodynamic behaviours for a diverse range o ....Exact solution of generalized models of polymers and percolation in two dimensions. Originating with the work of Rodney Baxter, Australia is the world leader in exactly solvable lattice models in two dimensions. This project, in strategic basic research, aims to continue this tradition and extend it by solving exactly new classes of two-dimensional lattice models involving nonlocal degrees of freedom. Since this will lead to new universal classes of thermodynamic behaviours for a diverse range of polymer-like systems, the potential for exploitation and commercialization is almost limitless. Potential applications include percolation of contaminants through aquifers, the spatial spread of epidemics and bushfires, the tertiary recovery of oil and filtering drinking water.Read moreRead less