Role Of Maternal And Obstetric Factors On Long-term Child Health & Educational Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$466,492.00
Summary
Natasha Nassar’s research program uses advanced research methods to address new challenges in child health in a portfolio that extends from bench-to-bedside-to-policy. She will investigate the role of maternal health, serum biomarkers, pregnancy complications and obstetric interventions, and birth on subsequent child health and development. Identification of at-risk children and involvement of clinicians and policy-makers should see her research result in improved child health outcomes.
Improving Long-term Weight Loss By Deactivating The Famine Reaction With Molecular Or Lifestyle Means
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Dr Amanda Sainsbury-Salis’ research will clarify which hormones and natural brain chemicals interact in the hypothalamus of the brain to control the famine reaction, the survival mechanism that slows your weight loss when you are on a diet. By knowing precisely which natural chemicals mediate the famine reaction and how they interact, it will be possible to weaken them by pharmaceutical and - or lifestyle means, thereby enabling more people to reap the benefits of being lean and healthy.
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
The Role Of Non-coding RNAs In Development And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
We have discovered a new mechanism by which genome activity is regulated. This project will test the hypothesis that this mechanism is critical for cell growth and embryonic development. It has the potential to identify new causes of birth defects and may also be relevant to understanding the etiology of other diseases such as cancer, resulting in improvements in diagnosis and management of disorders that present a major health care burden.