Using ‘omic and digital technologies toward better fasciolosis control. In Australia, liver fluke disease caused by Fasciola hepatica causes major economic losses to livestock production. Triclabendazole is the most effective drug for parasite control, however, resistance to this drug has emerged and continues to spread in Australia. This project expects to create a novel resource to identify new drug targets, generate new knowledge about the genetic composition of F. hepatica populations and un ....Using ‘omic and digital technologies toward better fasciolosis control. In Australia, liver fluke disease caused by Fasciola hepatica causes major economic losses to livestock production. Triclabendazole is the most effective drug for parasite control, however, resistance to this drug has emerged and continues to spread in Australia. This project expects to create a novel resource to identify new drug targets, generate new knowledge about the genetic composition of F. hepatica populations and unravel the genetic determinants underlying triclabendazole resistance. The curation of functionally-annotated genetic data for F. hepatica populations will underpin the development of diagnostic tests, drugs and vaccines to deliver a new generation of intervention strategies to control liver fluke disease.Read moreRead less
Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stres ....Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stress shielding typically associated with conventional implanting metals. The outcomes are expected to provide insights in designing biodegradable magnesium alloys and surface coating technology, and generate intellectual properties and advanced biomaterials that will benefit the Australian ageing population.Read moreRead less
Dynamically responding metals: a new generation of engineering alloys. The manufacture of engineering metals is a major Australian industry and the worldwide metal manufacturing sector is estimated to be worth $1 trillion USD per annum. Advanced materials and, particularly the light metals, are both designated national research priority areas. The availability of new classes of metals with greatly improved combinations of properties will profoundly affect not only metal use by existing industry, ....Dynamically responding metals: a new generation of engineering alloys. The manufacture of engineering metals is a major Australian industry and the worldwide metal manufacturing sector is estimated to be worth $1 trillion USD per annum. Advanced materials and, particularly the light metals, are both designated national research priority areas. The availability of new classes of metals with greatly improved combinations of properties will profoundly affect not only metal use by existing industry, through the introduction of new, stronger and safer metal grades, but also allows for new engineering designs which will lead, for example, to lighter and more efficient automobiles and more sustainable construction.Read moreRead less
Next generation titanium alloys for additive manufacturing. The rise of 3D printing creates unique opportunities for Australian manufacturers to participate in high value global supply chains. However, the lack of development in high quality printable materials is stopping manufacturers from accessing the full potential of 3D printing. This project aims to develop a design strategy for the next generation of titanium metals designed for 3D printing. This project expects to improve functionality ....Next generation titanium alloys for additive manufacturing. The rise of 3D printing creates unique opportunities for Australian manufacturers to participate in high value global supply chains. However, the lack of development in high quality printable materials is stopping manufacturers from accessing the full potential of 3D printing. This project aims to develop a design strategy for the next generation of titanium metals designed for 3D printing. This project expects to improve functionality of 3D printed metals with qualities that go beyond the most demanding industry acceptance criteria. This project should provide significant benefits by creating new capabilities and improving the productivity of Australian manufacturers while lowering the cost of products for consumers.Read moreRead less
Mechanics of innovative high precision rolling technology in micromanufacturing. This project will focus on the establishment of high precision rolling technology for manufacturing microparts in Australia by using a unique profile and flexible rolling method. A successful outcome will provide an important breakthrough in the microrolling area and new knowledge for advanced micromanufacturing technology and its applications.
Structure-property relationships in compositionally complex alloys. Physical metallurgy has entered a new era of compositionally complex metallic alloys that show unprecedented combinations of mechanical properties enabling the design of more energy-efficient and economically viable applications. This project aims to generate new knowledge about how locally-resolved, nano-scale atomic arrangements control macroscopic deformation behavior in these materials and develop a fundamental understanding ....Structure-property relationships in compositionally complex alloys. Physical metallurgy has entered a new era of compositionally complex metallic alloys that show unprecedented combinations of mechanical properties enabling the design of more energy-efficient and economically viable applications. This project aims to generate new knowledge about how locally-resolved, nano-scale atomic arrangements control macroscopic deformation behavior in these materials and develop a fundamental understanding of their processing-structure-fracture toughness relationships. Expected outcomes include an enhanced capacity to design materials with damage-tolerant properties superior to existing alloys from bottom up, thereby allowing for commercial benefits throughout transportation, defense, and biomedical device sectors.Read moreRead less
Discovery of signalling molecules that mediate communication in the environment. This project aims to further our understanding of chemical compounds that mediate communication in the environment. The project will identify a broad range of new compounds that have significant potential to provide new products such as anti-bacterials, pesticides and plant growth regulators for the benefit of Australia.
The role of structure in the formation and properties of glasses. This project aims to investigate the role of local atomic structure in the formation and mechanical properties of glasses by applying newly developed structure-determination methods. This project expects to establish why glasses form and how their structure gives rise to their undesirable, and limiting, brittle mechanical failure. The anticipated outcomes of this project are better ways to measure the atomic structure of disorder ....The role of structure in the formation and properties of glasses. This project aims to investigate the role of local atomic structure in the formation and mechanical properties of glasses by applying newly developed structure-determination methods. This project expects to establish why glasses form and how their structure gives rise to their undesirable, and limiting, brittle mechanical failure. The anticipated outcomes of this project are better ways to measure the atomic structure of disordered materials and the generation of more clear-cut structure-property relationships for glasses. This will provide significant benefit to Australian industries by enabling the design of better glass-forming systems and stronger, tougher glasses.Read moreRead less
Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic ....Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.Read moreRead less
Extending the frontiers of organocatalysis: new reactions involving nucleophilic carbenes. High technology solutions to the problems of today and tomorrow require new materials designed for specific activities. This project will deliver new technologies for the rapid and efficient assembly of materials designed for function.