Exploring The Role Of MicroRNA And Target Processing Variability In Cardiac Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$605,190.00
Summary
microRNAs are gene regulators with critical roles in heart disease. How interactions between microRNAs and their messenger RNA targets change during disease is poorly understood. We hypothesise that these interactions are critically affected by altered processing of microRNAs and targets. We will thus characterise and validate such differences in healthy and diseased hearts. This will define gene regulatory changes underpinning heart disease and contribute to the search for better treatment.
Investigating The Roles Of The Wnt And Notch Signalling Systems In Colon Cancer Crypt Biology
Funder
National Health and Medical Research Council
Funding Amount
$604,439.00
Summary
Colon cancer occurs because of mutations to a tumour suppressor gene. These mutations alter the growth and positional signals for the cancer cells. This project aims to produce a computer model of the regulatory processes in normal colonic cells, to discover why the mutations lead to cancer and to discover rational drug targets for interfering with the growth of colon cancer cells.