Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Neuropathic pain is particularly difficult to treat and existing medications have considerable side effects. This project will develop a new set of glycine transport inhibitors that have the potential to provide pain relief without side effects.
Cross-linking in free-radical polymerizations: kinetics and mechanical properties. Cross-linked polymer chains are joined together in a ?ladder? topology. This often occurs either deliberately or accidentally in industrial systems, and affects polymer properties. However, cross-linking mechanisms are poorly understood, and there are no general means of quantitatively controlling effects on mechanical properties. As a by-product from a previous IREX grant, a means was found to grow polymers with ....Cross-linking in free-radical polymerizations: kinetics and mechanical properties. Cross-linked polymer chains are joined together in a ?ladder? topology. This often occurs either deliberately or accidentally in industrial systems, and affects polymer properties. However, cross-linking mechanisms are poorly understood, and there are no general means of quantitatively controlling effects on mechanical properties. As a by-product from a previous IREX grant, a means was found to grow polymers with controlled cross-linking. This proposal exploits this method to synthesize polymers with different amounts of cross-linking, and to examine their formation mechanisms and mechanical properties. This has the potential of improving means of making rubber-based materials by polymer modification.Read moreRead less
The effect of competition and doctor heterogeneity on prices charged by doctors. Prices charged by doctors can have important effects on health care costs, access to health care and health status. This research will examine the determinants of prices charged by doctors. The results will be important in understanding the pricing practices of doctors and their impact on health care costs.
Nobody knows anything? Applying pari-mutuel prediction markets to the motion picture industry. This project will explore the predictability of unreleased motion pictures' theatrical box office revenues using incentive rich pari-mutuel prediction markets. The mechanism will promote price discovery and associated probability estimates that will benefit those already investing in the industry as well as encouraging new investment.
Mechanisms and modelling of gels for protein separation. Gradipore approached Sydney University to collaborate on fundamental science needed to improve polymer gels for separation and characterization of proteins. These gels have many applications: e.g. proteomics and diagnostics. Presently, control of polymer microstructure in the synthesis of these gels is by trial and error. This project will create an accurate model of the process so pore size can be predicted. This involves novel work in ex ....Mechanisms and modelling of gels for protein separation. Gradipore approached Sydney University to collaborate on fundamental science needed to improve polymer gels for separation and characterization of proteins. These gels have many applications: e.g. proteomics and diagnostics. Presently, control of polymer microstructure in the synthesis of these gels is by trial and error. This project will create an accurate model of the process so pore size can be predicted. This involves novel work in experimental and theoretical methods developed by the Sydney University group. The result will be qualitative and quantitative understanding which can be subsequently used to tailor-make gels for new applications.Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less