Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project ha ....Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project have been used previously to synthesise the anti-cancer metabolite roseophilin. The results of this project will ensure that there are many more similar success stories in the pharmaceutical and biotechnology industries.Read moreRead less
Experimental translocations to understand and combat eastern quoll declines. The project aims to understand the causes of observed declines of the eastern quoll in Tasmania, and develop tools to safeguard this species in their last wild stronghold. The project will test the innovative approach of undertaking a series of experimental translocations at an early stage of a population decline. This approach will provide reliable information on the causes of observed declines, while simultaneously te ....Experimental translocations to understand and combat eastern quoll declines. The project aims to understand the causes of observed declines of the eastern quoll in Tasmania, and develop tools to safeguard this species in their last wild stronghold. The project will test the innovative approach of undertaking a series of experimental translocations at an early stage of a population decline. This approach will provide reliable information on the causes of observed declines, while simultaneously testing the effectiveness of translocations of captive-bred animals as a management tool for the species. It will also develop evidence-based protocols for undertaking captive-bred translocations, to improve the outcomes of eastern quoll recovery efforts as well as promoting early intervention for other declining species. Read moreRead less
Skin friction control using engineering and biological surface coatings. The development of techniques to reduce skin friction in water conveying assets will increase renewable energy production from existing hydro-electric plant and improve the energy efficiency of water conveying utilities. There is also potential for application to marine biofouling problems and reducing fuel usage by shipping. Passive (non-chemical) and biological control methods to reduce fouling and friction will be sought ....Skin friction control using engineering and biological surface coatings. The development of techniques to reduce skin friction in water conveying assets will increase renewable energy production from existing hydro-electric plant and improve the energy efficiency of water conveying utilities. There is also potential for application to marine biofouling problems and reducing fuel usage by shipping. Passive (non-chemical) and biological control methods to reduce fouling and friction will be sought to minimise environmental impact and maintain potable water quality. This multidisciplinary project combining engineering, photogrammetry and biological sciences will provide valuable training for the project team members and develop a pool of skilled personnel available to Australian industries.Read moreRead less
Improvement of water conveying efficiency in hydroelectric power generation systems by optimising pipe friction losses. The growth of bacterial and algal slimes on the surface of water conveying system significantly reduces the net electricity generation from Tasmania's hydroelectric system.
The aim of this project is to develop an optimal maintenance strategy to control this growth which will balance maintenance downtime against the potential increase in electricity production. The growth resp ....Improvement of water conveying efficiency in hydroelectric power generation systems by optimising pipe friction losses. The growth of bacterial and algal slimes on the surface of water conveying system significantly reduces the net electricity generation from Tasmania's hydroelectric system.
The aim of this project is to develop an optimal maintenance strategy to control this growth which will balance maintenance downtime against the potential increase in electricity production. The growth response to cleaning techniques and surface coatings will be investigated.
The potential for increased power production from this renewable energy source will have considerable economic benefit for Tasmania.Read moreRead less
Determining generic indicators of stress in eucalypt leaves for application to the remote sensing of canopy condition and productivity modelling. Biotic and abiotic stresses induce generic alterations of leaf chemistry (e.g. chlorophyll, anthocyanins). We will explore the behaviour of eucalypt leaf reflectance to changes in leaf cellular chemistry and structure arising from exposure to a range of stressful factors. We will relate leaf reflectance to physiological processes using a research radia ....Determining generic indicators of stress in eucalypt leaves for application to the remote sensing of canopy condition and productivity modelling. Biotic and abiotic stresses induce generic alterations of leaf chemistry (e.g. chlorophyll, anthocyanins). We will explore the behaviour of eucalypt leaf reflectance to changes in leaf cellular chemistry and structure arising from exposure to a range of stressful factors. We will relate leaf reflectance to physiological processes using a research radiation interception model. We will report on a) the potential integration of data related to stress, into process-based models for eucalypt plantation growth and b) the exploitation of generic reflectance indicators of stress in the remote acquisition of high resolution multispectral imagery with potential to spatially quantify plantation eucalypt health.Read moreRead less
Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are i ....Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are in fact catalysed by metal nanoclusters. This project involves the application of advanced mass spectrometric and computational methods to explore the formation and reactivity of copper, silver and gold nanoclusters. Identification of key reactive intermediates will inform the design of next generation catalysts.Read moreRead less
A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of import ....A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of important organic reactions and enhancing collaboration nationally and internationally between computational and synthetic chemists. This should provide significant benefits in the form of improved chemical reactions for chemists to prepare new pharmaceuticals, agrochemicals and materials.Read moreRead less
AirLIFT – an airborne active chlorophyll fluorescence sensing system for assessment of photosynthetic activity in plant canopies. Assessment of plant health and productivity is vital to ensure future food security of the global population under a changing climate. Chlorophyll fluorescence (CF), a signal emitted by green plants, can reveal this information. Although CF has revolutionised photosynthetic research, current measurements are limited to individual plants. Remote sensing of canopy CF is ....AirLIFT – an airborne active chlorophyll fluorescence sensing system for assessment of photosynthetic activity in plant canopies. Assessment of plant health and productivity is vital to ensure future food security of the global population under a changing climate. Chlorophyll fluorescence (CF), a signal emitted by green plants, can reveal this information. Although CF has revolutionised photosynthetic research, current measurements are limited to individual plants. Remote sensing of canopy CF is required for efficient management of agricultural crops, forests, and natural ecosystems and is crucial for accurate estimation of plant carbon assimilation and production. This project will deliver remote sensing technology to bridge the gap between leaf and canopy productivity and pave the way for understanding both artificial and solar induced canopy CF measured from space.Read moreRead less
Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in sit ....Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.
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Towards an Active and Passive L- and P-band soil moisture satellite mission. This project tests alternate configurations for remote sensing of soil moisture using a new state-of-the-art Active/Passive (ie radar/radiometer) P-/L-band (ie microwave) satellite concept through a series of airborne field experiments. Timely soil moisture information is critical to improved water management for food production in the face of climate variability. The challenge is to do this accurately over large areas ....Towards an Active and Passive L- and P-band soil moisture satellite mission. This project tests alternate configurations for remote sensing of soil moisture using a new state-of-the-art Active/Passive (ie radar/radiometer) P-/L-band (ie microwave) satellite concept through a series of airborne field experiments. Timely soil moisture information is critical to improved water management for food production in the face of climate variability. The challenge is to do this accurately over large areas with an appropriate spatio-temporal detail, and for a soil depth that closely approximates the layer which impacts crop/pasture growth and influences management decisions. The longer P-band allows deeper penetration into the soil while the active/passive combination uses the respective resolution and accuracy characteristics.Read moreRead less