Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the ....Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the bladder. Project research into the design of the electrode will focus on providing safe, effective and efficient stimulation of the neosphincter, while ensuring minimal damage to the surrounding tissues and affording straightforward implantation at surgery.Read moreRead less
Development of an electrode assembly for the stimulation of a transplanted innervated smooth muscle sphincter. This project will design and assess a number of different electrode designs for use in a medical device being developed for the treatment of severe stress urinary incontinence. The project will identify an optimal electrode design, which will be used in future clinical trials of the device.
Scaling microfluidics for cell manufacture. Scaling microfluidics for cell manufacture. This project aims to scale microfluidic devices for cell manufacture. Large-scale cell manufacturing processes (cell selection, gene transfer and culture expansion) are expensive, multistep and labour-intensive processes. Lab-on-a-chip devices can automate and integrate these complex processes at microscale. This project will evaluate a prototype bioreactor. This research is expected to make cell therapies ch ....Scaling microfluidics for cell manufacture. Scaling microfluidics for cell manufacture. This project aims to scale microfluidic devices for cell manufacture. Large-scale cell manufacturing processes (cell selection, gene transfer and culture expansion) are expensive, multistep and labour-intensive processes. Lab-on-a-chip devices can automate and integrate these complex processes at microscale. This project will evaluate a prototype bioreactor. This research is expected to make cell therapies cheap enough to become standard treatment, which would benefit patients with diseases that are incurable by conventional therapies (surgery and drug treatments). It should also benefit the Australian advanced manufacturing sector, particularly biopharmaceutical and cell therapy industries.Read moreRead less
Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved ....Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved energy and power density batteries which will lead to immediate implementation of more powerful signal processing algorithms, making hearing aids much more effective and appealing to the user. This, in turn, will improve recipient compliance and thus the quality of life for those with severe hearing impairment. Read moreRead less
Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic det ....Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. Rapid CYBERNOSE ® detection of illicit drugs and precursor chemicals. This project aims to develop a novel biosensor prototype based on CYBERNOSE® technology to rapidly identify volatile traces of illicit drugs and precursor chemicals in concealed environments. The CYBERNOSE® technology employs sensors using the highly sophisticated and sensitive olfactory receptors of microscopic nematode worms linked to an optoelectronic detector. The need for rapid, non-contact screening devices to detect and identify illicit drugs and precursors entering Australia has never been greater. Law enforcement agencies should directly benefit from the capability to more rapidly screen people and cargo, improving efficiency of illicit drug detection and protection of our borders.Read moreRead less
Synthetic Biology Derived Electroactive Whole Cell Microbial Biosensors. The aim of this project is to develop, using synthetic biology, electrically integrated microbial biosensors for the detection of heavy metals in the environment. Building on our existing technology, this project aims to produce novel ‘biobricks’ capable of electrically integrating electric microbes into real time environmental monitors for heavy metal contaminants. This expansion of synthetic biology, and integration of el ....Synthetic Biology Derived Electroactive Whole Cell Microbial Biosensors. The aim of this project is to develop, using synthetic biology, electrically integrated microbial biosensors for the detection of heavy metals in the environment. Building on our existing technology, this project aims to produce novel ‘biobricks’ capable of electrically integrating electric microbes into real time environmental monitors for heavy metal contaminants. This expansion of synthetic biology, and integration of electric bacteria into sensor systems, will result in a new platform technology that expands our abilities to protect the ecology, agriculture and health of terrestrial, marine and agricultural at risk areas from economic and environmental damage.Read moreRead less
Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, re ....Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and bioinformatics; increase global visibility with increased investment in Australian science; improved animal welfare and production via better control of infectious diseases; commercial products with benefits to agricultural producers in regional and rural communities.Read moreRead less
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated c ....Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated compounds, will inform handling of contaminated sites and lead to development of cost effective and sustainable remediation technologies. Read moreRead less
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.