Developing a competitive H2 production suystem based on engineered cells of green algae. The depletion of oil reserves and the effects of global warming make the development of new, clean, sustainable fuel production systems critically important. This frontier technology has the ability to drive solar-powered hydrogen production from water. Extending the system to marine algal cells provides the possibility of coupling clean fuel production with water purification as the product of H2 combustion ....Developing a competitive H2 production suystem based on engineered cells of green algae. The depletion of oil reserves and the effects of global warming make the development of new, clean, sustainable fuel production systems critically important. This frontier technology has the ability to drive solar-powered hydrogen production from water. Extending the system to marine algal cells provides the possibility of coupling clean fuel production with water purification as the product of H2 combustion is pure water. We have already engineered green algae that produce H2 from H2O at a rate ~1000% higher than the Wild-type and through this project will incorporate further improvements with the aim of developing a competitive H2 production system.Read moreRead less
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discov ....Sequencing the mammalian transcriptome in toto. The mammalian genome projects have provided a huge leap forward for biological research by giving the framework to study genes on a global scale. This project will provide human genome project scale information for every major tissue in mammals and will provide the research community with a world class resource to further genomic research. It will also investigate parts of gene regulation which have been invisible to researchers in the past. Discovering these rules will provide novel insights in pathology with a genetic component and provide a further boost to biotechnological approaches to obtain expression of specific sets of genes in model systems. Read moreRead less
A New Window into Transgene Silencing in Plants: mechanisms of copy-number independent, 5' sequence dependent, post-transcriptional silencing in a complex polyploid. Silencing of introduced genes is a major problem limiting plant molecular improvement. Sugarcane, a complex polyploid, shows the most efficient transgene silencing ever observed in plants. Silencing operates on the RNA, depends on the upstream sequence of the gene, and is independent of copy number. Other plant species develop endop ....A New Window into Transgene Silencing in Plants: mechanisms of copy-number independent, 5' sequence dependent, post-transcriptional silencing in a complex polyploid. Silencing of introduced genes is a major problem limiting plant molecular improvement. Sugarcane, a complex polyploid, shows the most efficient transgene silencing ever observed in plants. Silencing operates on the RNA, depends on the upstream sequence of the gene, and is independent of copy number. Other plant species develop endopolyploidy with age, and show unpredictable or patchy silencing. We speculate that differential silencing is a natural control mechanism in the exploitation of polyploidy in plants. The sugarcane system provides an exceptional opportunity to identify the sequences that trigger and protect from silencing, and to develop approaches to avoid the problem.Read moreRead less
Clean fuels for the future: Scale up and optimisation of microalgal oil production and biodiesel synthesis. The development of renewable carbon-neutral fuels is an urgent challenge facing our society. This project aims to develop an innovative system for biodiesel production from local Australian algae species. If cultivated under the right conditions, microalgae are very efficient near-continuous producers of biodiesel and are likely the only renewable source of fuel that could match our curren ....Clean fuels for the future: Scale up and optimisation of microalgal oil production and biodiesel synthesis. The development of renewable carbon-neutral fuels is an urgent challenge facing our society. This project aims to develop an innovative system for biodiesel production from local Australian algae species. If cultivated under the right conditions, microalgae are very efficient near-continuous producers of biodiesel and are likely the only renewable source of fuel that could match our current and future demand without competing for arable land and food production. Such systems couple the national/community benefits of energy generation, carbon-capture, biodiesel production and the clean-up of wastewater. Successful outcomes from this project will bring this innovative technology closer to commercial reality. Read moreRead less
Second generation biofuels: developing environmentally friendly high-efficiency microalgae for biofuel production. The development of CO2-neutral (biodiesel) and CO2-free (hydrogen) fuels is an urgent challenge facing our society to combat climate change and protect against oil price shocks. Successful outcomes from this project will bring this innovative technology closer to commercial reality. The solar-powered microalgal systems being developed, offer a number of national/community benefits ....Second generation biofuels: developing environmentally friendly high-efficiency microalgae for biofuel production. The development of CO2-neutral (biodiesel) and CO2-free (hydrogen) fuels is an urgent challenge facing our society to combat climate change and protect against oil price shocks. Successful outcomes from this project will bring this innovative technology closer to commercial reality. The solar-powered microalgal systems being developed, offer a number of national/community benefits including
1. A high-efficiency frontier-technology for clean fuel production for the Australian and international market
2. A new process to desalinate water
3. Frontier technology to sequester atmospheric CO2
4. Frontier technologies for wealth generation in drought- or salinity-affected and naturally arid regionsRead moreRead less
Targeted bioengineering and systems biology for solar powered hydrogen production in green algal cells. The development of clean fuels to combat climate change and protect against oil price shocks, is an urgent challenge facing our society. Fuels make up ~67% of the energy market, yet most low-CO2 emissions technologies (e.g. nuclear and clean-coal-technology) target the electricity market. In contrast the Solar Bio-H2 process uses algal photobioreactors to drive solar-powered H2 fuel production ....Targeted bioengineering and systems biology for solar powered hydrogen production in green algal cells. The development of clean fuels to combat climate change and protect against oil price shocks, is an urgent challenge facing our society. Fuels make up ~67% of the energy market, yet most low-CO2 emissions technologies (e.g. nuclear and clean-coal-technology) target the electricity market. In contrast the Solar Bio-H2 process uses algal photobioreactors to drive solar-powered H2 fuel production from water (ultimately sea water, facilitating desalination). This project aims to improve the efficiency of the process towards economical levels. The Solar Bio-H2 process reduces water requirements for biofuel production. Locating bioreactors on non-arable land also eliminates competition between biofuel and food production.Read moreRead less
Plant transformation: exploiting anti-apoptosis genes for very high efficiency transformation. Crop improvement through genetic modification depends on the ability to transform target species. The most desirable method is Agrobacterium mediated transformation. However, plant species and cultivars differ significantly in their ability to be efficiently transformed by Agrobacterium. This is particularly true for the economically important cereals. We have discovered that anti-apoptosis genes, whic ....Plant transformation: exploiting anti-apoptosis genes for very high efficiency transformation. Crop improvement through genetic modification depends on the ability to transform target species. The most desirable method is Agrobacterium mediated transformation. However, plant species and cultivars differ significantly in their ability to be efficiently transformed by Agrobacterium. This is particularly true for the economically important cereals. We have discovered that anti-apoptosis genes, which inhibit programmed cell death, dramatically increase the Agrobacterium transformation efficiency in bananas and sugarcane. We will utilise this information and develop the use of these genes to increase the efficiency of transformation in those crops and cultivars that are difficult to transform using Agrobacterium.Read moreRead less
Progenitor cells within the peritoneal cavity. Implantation of a foreign object into the peritoneal cavity of animals recruits undifferentiated cells of bone marrow origin that encapsulate the free-floating object, then differentiate into myofibroblasts. When large pieces of myofibroblast capsule tissue are subsequently grafted into autologous artery, bladder or vas deferens, they develop the structure and morphology of that organ. We hypothesise that multipotent progenitor cells sequestered t ....Progenitor cells within the peritoneal cavity. Implantation of a foreign object into the peritoneal cavity of animals recruits undifferentiated cells of bone marrow origin that encapsulate the free-floating object, then differentiate into myofibroblasts. When large pieces of myofibroblast capsule tissue are subsequently grafted into autologous artery, bladder or vas deferens, they develop the structure and morphology of that organ. We hypothesise that multipotent progenitor cells sequestered to the peritoneal cavity can be manipulated to differentiate along smooth muscle and other pathways. The proposed project aims to identify the origin of these cells and characterise the transcriptional program that regulates their differentiation.Read moreRead less
Using genomic information to understand and improve the quality of the Australian South Sea Pearl. Recently, mass-produced freshwater pearls from Asia have markedly increased in quality and begun to compromise our prestigious South Sea Pearl market. This presents Australian pearlers with a challenge to maintain market identity by improving their pearl quality and consistency. By adding genomics to the existing Australian pearl industry armoury we will help not only to maintain the premier positi ....Using genomic information to understand and improve the quality of the Australian South Sea Pearl. Recently, mass-produced freshwater pearls from Asia have markedly increased in quality and begun to compromise our prestigious South Sea Pearl market. This presents Australian pearlers with a challenge to maintain market identity by improving their pearl quality and consistency. By adding genomics to the existing Australian pearl industry armoury we will help not only to maintain the premier position of the Australian South Sea Pearl in the market, but also to move it further ahead. Knowledge of the genetics of pearl formation will advance a range of hatchery and farm practices, such as selective breeding and pearl grafting, which in turn can enhance farm-based operations and the remote communities that support them.Read moreRead less