Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775529
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Structural elucidation by chemical degradation mass spectrometry using a linear ion trap with electron transfer dissociation. The mass spectrometric instrumentation that we plan to acquire represents a true breakthrough in technology, and will be the first of its kind in operation in Australia. The instrument to be purchased will improve the ability of a wide cross section of researchers to characterize compounds important in fields as varied as medical research, agricultural biotechnology, and ....Structural elucidation by chemical degradation mass spectrometry using a linear ion trap with electron transfer dissociation. The mass spectrometric instrumentation that we plan to acquire represents a true breakthrough in technology, and will be the first of its kind in operation in Australia. The instrument to be purchased will improve the ability of a wide cross section of researchers to characterize compounds important in fields as varied as medical research, agricultural biotechnology, and natural product characterization. All types of chemical research, from fundamental to applied, will benefit from access to this system, which has clearly positive implications with regard to societal impact. Implementing this type of frontier technology is an essential step in maintaining the world class capabilities of the Australian research community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454008
Funder
Australian Research Council
Funding Amount
$340,962.00
Summary
Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed faci ....Multi-function high resolution-analytical scanning electron microscope facility. The aim of this proposal is to establish a high resolution electron microscope facility as part of a comprehensive materials characterisation infrastructure required to support Swinburne's expanding activities in nanotechnology. A high resolution SEM in conjunction with an upgrade of the current SEM will provide advanced instrumentation for nanoscale imaging, analysis and manipulation of materials. The proposed facility will create new opportunities for collaborative programs with local and overseas researcher and will facilitate rapid progress in research programs across the entire University in particular those related to two ARC Centres of Excellence in which the University is a core partner.Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modificatio ....New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modification, as a basis for high-throughput mass spectrometrical analyses;
- development of an algorithm for rapid resonance assignment of 15N-labelled proteins which is of importance for the pharmaceutical industry;
- 3D structure determinations of proteins and protein domains.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354640
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Young Investigators Network on Next Generation Electronic Devices. This initiative will build an active, dynamic and strongly interdisciplinary network of young Australian scientists (most awarded their Ph.D. after 1985) working on the development of innovative electronic devices - a national research priority area with enormous economic and technological opportunity. The network will enable a nationally coordinated, internationally competitive approach that capitalizes on untapped opportunitie ....Young Investigators Network on Next Generation Electronic Devices. This initiative will build an active, dynamic and strongly interdisciplinary network of young Australian scientists (most awarded their Ph.D. after 1985) working on the development of innovative electronic devices - a national research priority area with enormous economic and technological opportunity. The network will enable a nationally coordinated, internationally competitive approach that capitalizes on untapped opportunities, utilises existing/emerging Australian expertise and develops strong supporting links with similar networks overseas. The initiative will produce a public showcase of Australian strengths and opportunities in this field, and enable stronger collaborations and cooperative logistics management through the development of a dedicated network management website.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective ....Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective insecticides. The range of new materials and protocols that will result from the research will be suitable for commercial exploitation. Particular benefit to Australians will result from the research being carried out locally, where the intellectual property and expertise will be developed and maintained.Read moreRead less