Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100094
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Selective laser melting - an advanced manufacturing and physical modelling technology for the digital age. Selective laser melting is a new manufacturing technology that creates parts layer by layer directly from a computer model, eliminating the need for tooling or machining. This technology will be applied to a diverse range of research areas from producing the next generation of medical implants and devices to improving our understanding of geo-materials.
Special Research Initiatives - Grant ID: SR0354735
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Network on Microelectronics, Optoelectronics and Microelectromechanical Systems. The Network will encompass semiconductor microelectronics, optoelectronics, sensors and microelectromechanical systems (MEMS). Fundamental research in these areas enables the technological advances that underpin rapidly developing industries such as information and telecommunications technologies, defence, aerospace, medicine, and remote sensing. Exciting challenges exist in designing new devices that exp ....Australian Network on Microelectronics, Optoelectronics and Microelectromechanical Systems. The Network will encompass semiconductor microelectronics, optoelectronics, sensors and microelectromechanical systems (MEMS). Fundamental research in these areas enables the technological advances that underpin rapidly developing industries such as information and telecommunications technologies, defence, aerospace, medicine, and remote sensing. Exciting challenges exist in designing new devices that exploit unique semiconductor systems and technologies. By sharing capabilities and resources (both capital and human), the network will enable the issues associated with such novel materials and devices to be addressed in a targeted manner. The network will also guarantee the ongoing future of research in the area by actively involving early career researchers and postgraduate students.Read moreRead less
Investigation of novel magneto-optic materials exhibiting high Faraday figure of merit. Magneto-optical materials have a wide range of potential applications in consumer products, telecommunications and defence. Nanotechnologies based on these materials offer an even broader range of emerging applications. Understanding and participating in the development of magneto-optic technologies will therefore be critical to maintaining Australia's knowledge base and expertise in future technological adv ....Investigation of novel magneto-optic materials exhibiting high Faraday figure of merit. Magneto-optical materials have a wide range of potential applications in consumer products, telecommunications and defence. Nanotechnologies based on these materials offer an even broader range of emerging applications. Understanding and participating in the development of magneto-optic technologies will therefore be critical to maintaining Australia's knowledge base and expertise in future technological advances. Given the early stages of development of these technologies, Australia's expertise in material science and the patent rights held by Australian companies in this area, Australia has the opportunity to make major contributions to this field, and the potential to capitalise on the application of these technologies in niche markets.Read moreRead less
Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will p ....Levelling the Playing Field: Starting with the School Playground. This project aims to demonstrate the effectiveness of simple, cost-effective programs for changing the way parents and teachers view manageable risk-taking for children with disabilities and increasing the level of responsibility that children take for their own actions. The well-being of all children with disabilities is at risk and the gap continues to widen. New programs, such as the National Disability Insurance Scheme, will place increasing demands on young people with disabilities. Innovative approaches are desperately. Such programming must begin early, by including children in an age-appropriate ways and simultaneously addressing the issues of adults who have the most significant influence: parents and teachers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0667994
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
National Nanolithography Facility. Nanotechnology is expected to have a major impact on quality of life and global economy. It is predicted to generate revenues as big as the ICT sector in 20 years time. The National Nanolithography Facility will enhance the Australian capability in the field of nanoscale science and technology. This will enable Australian researchers to achieve major impacts in many areas of nanotechnology with a strong potential impact on industry sectors such as computers, ....National Nanolithography Facility. Nanotechnology is expected to have a major impact on quality of life and global economy. It is predicted to generate revenues as big as the ICT sector in 20 years time. The National Nanolithography Facility will enhance the Australian capability in the field of nanoscale science and technology. This will enable Australian researchers to achieve major impacts in many areas of nanotechnology with a strong potential impact on industry sectors such as computers, communications, defence, health, bio-security. This facility has the potential for developing new technologies of fundamental as well as applied interest.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100126
Funder
Australian Research Council
Funding Amount
$527,638.00
Summary
Advanced Maskless Photolitography for Western Australia. This project aims to close an existing gap in micro- & nano-fabrication in Western Australia and provide access to advanced maskless photolithography in support of Australian research flagships of international excellence which include advanced infrared and quantum technologies, semiconductor optoelectronics, chemical engineering, microelectromechanical systems, as well as dark matter and gravitational wave discovery. Notably, the new capa ....Advanced Maskless Photolitography for Western Australia. This project aims to close an existing gap in micro- & nano-fabrication in Western Australia and provide access to advanced maskless photolithography in support of Australian research flagships of international excellence which include advanced infrared and quantum technologies, semiconductor optoelectronics, chemical engineering, microelectromechanical systems, as well as dark matter and gravitational wave discovery. Notably, the new capability is of utmost importance for five distinct ARC Centres in multidisciplinary areas and will be available to all researchers via the WA Node of Australian National Fabrication Facility in support of high impact scientific research and to maintain strong engagement with industry and Australian economy.Read moreRead less