Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research act ....Effective Microfluidic Cell Sorting using Synergistic Acoustic and Optical manipulation. The fluorescence-activated cell sorting technique alone represented a US$860 million market in worldwide diagnostic and life science research devices for 2004. The development of a faster and cheaper device with similar efficacy, as per the objective of this work, has the potential of supplanting immunological methods of cell sorting and thus yield substantial economic returns to the nation. The research activities in this project will strengthen Australia's research standing in the fields of microfluidics and lab-in-a-chip technologies. On a broader platform, it will contribute to Australia's high standing in the field of biotechnology.Read moreRead less
Advanced model-based control for ultra-fast and ultra-high-precision nanoscale positioning. Australia faces unique challenges due to its small population and distance from international markets. To maintain a high standard of living Australia needs to further develop its high-tech base particularly in emerging fields such as nanotechnology. This research program is aimed at placing Australia at the forefront of international research in nanoscale positioning systems by building a world-class tea ....Advanced model-based control for ultra-fast and ultra-high-precision nanoscale positioning. Australia faces unique challenges due to its small population and distance from international markets. To maintain a high standard of living Australia needs to further develop its high-tech base particularly in emerging fields such as nanotechnology. This research program is aimed at placing Australia at the forefront of international research in nanoscale positioning systems by building a world-class team of talented researchers and equipping them with world-class research infrastructure. The global market for nanotechnology is projected to be in the tens of billions of dollars by 2020. The proposed research will enhance Australia's competitive advantage through high-impact scientific and technological innovations in nanotechnology.Read moreRead less
Robust Control Design using Micro-Actuators. Recent advances in micro-actuators have enabled many new applications in complex systems. Examples include ultra-high density disk drives, low-cost vibration tables, and micro-robotic systems. However, control design for these systems is very challenging because the micro-actuators have severely limited dynamic ranges and strong couplings. The proposed project aims to study new control design approaches for these complex systems. The work will focus o ....Robust Control Design using Micro-Actuators. Recent advances in micro-actuators have enabled many new applications in complex systems. Examples include ultra-high density disk drives, low-cost vibration tables, and micro-robotic systems. However, control design for these systems is very challenging because the micro-actuators have severely limited dynamic ranges and strong couplings. The proposed project aims to study new control design approaches for these complex systems. The work will focus on both theoretical studies and experimental applications of such systems. The outcome of the project will help put Australia in a more advanced position in this niche area of leading age technology.Read moreRead less
Magnetic Resonance Imaging in Inhomogeneous Magnetic Fields-Part A: The Development of Imaging Methods Using Even Order Zonal Fields. Part B: Slice Correction Due to Non-linear Gradient Fields. The primary aims of this project are to contribute to the new generation of MRI methodologies through technical innovation, with particular emphasis on NMR imaging under inhomogeneous magnetic fields. The new techniques will be of enormous benefit for superconducting magnet design, reducing material usage ....Magnetic Resonance Imaging in Inhomogeneous Magnetic Fields-Part A: The Development of Imaging Methods Using Even Order Zonal Fields. Part B: Slice Correction Due to Non-linear Gradient Fields. The primary aims of this project are to contribute to the new generation of MRI methodologies through technical innovation, with particular emphasis on NMR imaging under inhomogeneous magnetic fields. The new techniques will be of enormous benefit for superconducting magnet design, reducing material usage, and eliminating the need for the expensive post-production shimming process. The entailed project is extremely challenging, while preliminary calculations presented in this application show some progress towards demonstration of feasibility. The program is an ambitious one with a full R&D program over 3 years, which will provide leadership, and to both foster and focus research interest in Australian engineering and scientific endeavors in the field of Magnetic Resonance technology.Read moreRead less
High Field Magnetic Resonance Engineering. The use of high resolution MRI is increasingly important in the quest for molecular imaging and the development of a range of gene therapies, stem cell research and the trialling of new drugs. This research will add momentum to Australia's health technology research community with positive impact on its international research and development profile. Successful outcomes will improve both the applicability and cost-effectiveness of numerous current and ....High Field Magnetic Resonance Engineering. The use of high resolution MRI is increasingly important in the quest for molecular imaging and the development of a range of gene therapies, stem cell research and the trialling of new drugs. This research will add momentum to Australia's health technology research community with positive impact on its international research and development profile. Successful outcomes will improve both the applicability and cost-effectiveness of numerous current and potential medical and non-medical imaging systems with subsequent potential for improved diagnosis in the biotech and health sectors in Australia and overseas. Successful outcomes will provide economic returns through licensing payments from the generated intellectual property.Read moreRead less
Transceive Phased Arrays for Parallel Imaging in High Field Magnetic Resonance Microscopy. This project will contribute to the development of a new generation of Magnetic Resonance Imaging systems that provide new and innovative features capable of significantly increasing the resolution and /or speed of imaging. The economic benefit of being a developer of this technology is clear and significant. These new systems will enhance the efficiency and power of clinical diagnostic testing. Specifica ....Transceive Phased Arrays for Parallel Imaging in High Field Magnetic Resonance Microscopy. This project will contribute to the development of a new generation of Magnetic Resonance Imaging systems that provide new and innovative features capable of significantly increasing the resolution and /or speed of imaging. The economic benefit of being a developer of this technology is clear and significant. These new systems will enhance the efficiency and power of clinical diagnostic testing. Specifically, the enabling of molecular imaging will enhance the study of many more disease states and rapid assessment of new in vivo therapeutic agents. The side-stream benefit to biomedical research and development in Australia is therefore substantial. Read moreRead less
Advanced MRI Engineering. Magnetic Resonance Imaging is rapidly becoming the medical imaging modality of choice for soft tissue injuries. The technology development of MRI, however, is relatively young with only 20 years or so of commercial development. The major aim of this project is to contribute to this and the next generation of MRI scanners through technical innovation. New engineering design methods will be developed and used to generate novel superconducting magnet systems and associated ....Advanced MRI Engineering. Magnetic Resonance Imaging is rapidly becoming the medical imaging modality of choice for soft tissue injuries. The technology development of MRI, however, is relatively young with only 20 years or so of commercial development. The major aim of this project is to contribute to this and the next generation of MRI scanners through technical innovation. New engineering design methods will be developed and used to generate novel superconducting magnet systems and associated equipment. A strong focus of the design work will be to include electromagnetic models of the patient in the equipment design. This will not only ensure improved accuracy and speed of MRI scans, but also better patient safety, comfort and clinician access.Read moreRead less
Solutions for reducing magnetic resonance image degradations and tissue heating at high frequencies. This project will contribute to the development of the high-end Magnetic Resonance Imaging (MRI) systems that can substantially improve the image quality, speed of imaging and patient safety in MRI. The project will develop innovative high radio frequency hardware and control methods for imaging. Successful outcomes of this project will, facilitate higher patient throughput in hospitals, provisi ....Solutions for reducing magnetic resonance image degradations and tissue heating at high frequencies. This project will contribute to the development of the high-end Magnetic Resonance Imaging (MRI) systems that can substantially improve the image quality, speed of imaging and patient safety in MRI. The project will develop innovative high radio frequency hardware and control methods for imaging. Successful outcomes of this project will, facilitate higher patient throughput in hospitals, provision of more powerful clinical imaging tools to aid early diagnosis and various research modalities ranging from molecular to real-time imaging during interventional procedures.Read moreRead less
Measurement of the spatial distribution of temperature and velocity in lakes using Acoustic Tomography. This project will investigate the use of acoustic tomography in lakes to continuously measure the lake-wide distribution of temperature and velocity. The challenges with lake acoustic tomography are the accuracy required in the travel time measurements over shorter distances, acoustic losses due to reflections and ensuring enough rays travel through the thermocline, the region of greatest inte ....Measurement of the spatial distribution of temperature and velocity in lakes using Acoustic Tomography. This project will investigate the use of acoustic tomography in lakes to continuously measure the lake-wide distribution of temperature and velocity. The challenges with lake acoustic tomography are the accuracy required in the travel time measurements over shorter distances, acoustic losses due to reflections and ensuring enough rays travel through the thermocline, the region of greatest interest in lakes. A pilot experiment in a deep lake will investigate the quality of travel time measurements computed from rays travelling through the thermocline of a strongly stratified lake. This has wide applications for the water quality management of lakes and reservoirs.Read moreRead less
Acoustic observation of Antarctic ice rifting and calving events using remote hydroacoustic listening stations. The calving activity of the Antarctic ice shelves is one of the major indicators of global climate change. Global warming induced by an increase in atmospheric CO2 will affect the Antarctic Ice Sheet, primarily in form of disintegration of the Antarctic ice shelves surrounding the continent. The processes of calving on the ice shelves may lead to a substantial increase of sea level aro ....Acoustic observation of Antarctic ice rifting and calving events using remote hydroacoustic listening stations. The calving activity of the Antarctic ice shelves is one of the major indicators of global climate change. Global warming induced by an increase in atmospheric CO2 will affect the Antarctic Ice Sheet, primarily in form of disintegration of the Antarctic ice shelves surrounding the continent. The processes of calving on the ice shelves may lead to a substantial increase of sea level around the world, with devastating effects on the continental coasts and low-lying islands. The method of remote acoustic observations investigated in this project is a new approach to the problem of creating an efficient and cost effective system to monitor rifting and calving of the Antarctic ice shelves. Read moreRead less