Centre For Research Excellence In Developmental And Epileptic Encephalopathies
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
We will study the clinical, genetic and psychological aspects of patients with the most severe group of epilepsies, the Developmental and Epileptic Encephalopathies (DEEs). We will define the clinical spectrum of each genetic DEE, improve health outcomes through understanding the natural history of these diseases, build an integrated model of care, produce family resources and assess health economic impacts. This program will ensure Australia is poised for emerging Precision Medicine trials.
Our centre combines clinical and laboratory expertise to tackle autoimmune, inflammatory, and immune deficiency diseases. Starting from a genetic discovery platform, we aim to understand precisely how the immune system goes wrong in each individual patient to cause disease. This approach will make diagnoses more accurate and tailor treatment to each patient. The centre's approach should provide a template for the implementation of genomics and personalized medicine into routine clinical practice
Integrated Community Care For People With Complex Multi-morbidities
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The focus of the Centre of Research Excellence (CRE) for Integrated Community Care for People with Complex Multi-morbidities (CRE-CoM) will be on reducing hospitalisation through innovative, high quality, collaborative research of home and community-based service systems, including the development of digital and virtual modes of community-based service delivery.
Centre Of Research Excellence For The Study Of Naevi
Funder
National Health and Medical Research Council
Funding Amount
$2,496,835.00
Summary
Most melanomas grow adjacent to or within pre-existing benign neoplasms of the skin called naevi. Many studies have shown that the number of nevi on an individual predicts their risk of developing melanoma. New naevi form and existing ones change regularly in children and also adults. While previous work aimed to reduce the burden of melanoma has focussed on malignant tumours, much can be learned from increasing our understanding of tumorigenesis by studying benign tumours such as naevi.
Centre For Research Excellence In Speech And Language Neurobiology (CRE-SLANG)
Funder
National Health and Medical Research Council
Funding Amount
$2,491,340.00
Summary
Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment options and social isolation. Current speech therapy is limited, focusing on symptoms and ignoring evidence on underlying aetiologies. By identifying and translating findings on new genes and brain pathways leading to speech and language disorders, we will transform detection, diagnosis, prognosis and genetic counselling of affected children and their families.
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
NHMRC Asia Pacific Centre For Innovative Dengue Prevention
Funder
National Health and Medical Research Council
Funding Amount
$2,753,925.00
Summary
World Health Organization estimates dengue incidence at around 50 million cases annually with increased frequency & severity of outbreaks in north Queensland over the last decade being mirrored around the world. The NHMRC Asia Pacific Centre for Innovative Dengue Prevention will be a world leading research facility, co-supported by Bill and Melinda Gates Foundation Grand Challenges in Global Health, focussed on the discovery and implementation of innovative methods to eliminate dengue.
Bowel cancer, the second most diagnosed and cause of cancer death is preventable. Low risk people need no screening or just inexpensive fecal occult blood tests. Increased risk people need the more expensive and invasive colonoscopies. There is overuse of colonoscopy by those at low risk and underuse by those at high risk. Our Centre brings together scientists, epidemiologists and clinicians to develop a personalised risk tool and methods to implement the tool to increase appropriate screening.
Centre Of Research Excellence In Prehospital Emergency Care
Funder
National Health and Medical Research Council
Funding Amount
$2,499,626.00
Summary
The Prehospital Emergency Care - Centre for Research Excellence (PEC-CRE) will build capacity in prehospital research in Australia through the conduct of collaborative research projects between academic researchers, clinicians and ambulance service providers. The overarching goal of the PEC-CRE will be to strengthen the evidence base underpinning prehospital emergency care policy and practice, to ensure that ambulance patients receive ‘the right care, in the right place, at the right time’.
Testing, Translation And Uptake Of Evidence In General Practice: A Systems Approach To Rapid Translation
Funder
National Health and Medical Research Council
Funding Amount
$2,411,050.00
Summary
Testing, Translation & Uptake of Evidence in General Practice: A systems approach. Though General Practice is the frontline of Australia’s health system, new research findings are often ignored by busy GPs, resulting in suboptimal care. We plan to improve this by: A. A network of influential GPs practices to test new research, B. Practice support units who provide GP and patient summaries of new research, C. Active transfer of successful new practices via social media, guidelines, and courses.