Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will ....Information support tools for the trauma patient pathway. Processes such as critical supply chain management, disaster management, and trauma patient pathways need people, resources, and information to be smoothly transferred between jurisdictions, but problems can occur at each handover. This project focuses on the prehospital to hospital patient pathway and aims to develop technologies, devices, and displays to support more effective handover of patients between jurisdictions. The project will conduct field research, design activities, and simulation-based evaluation of prototypes with healthcare professionals. Expected outcomes are designs, technologies, and guidelines that will generalise to other multi-jurisdictional processes. Benefits are safer and more efficient handover processes.Read moreRead less
The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyami ....The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.Read moreRead less
A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce ....A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce a platform technology designed for subscalp anatomy with future use in various brain-machine interfacing applications relying on reliable, long-term and easy-to-implant systems. This project's device manufacturing, training, and intellectual property are expected to strengthen Australia's position in bioelectronics.Read moreRead less
Communicating to promote engagement in using electronic medical records. This reflexive ethnographic and co-design project aims to examine how patient and family participation occurs with health professionals in using the electronic medical record within hospitals, especially for patients with complex needs. Its significance involves working with patients and families to consider how they could take part in decision making activities across transitions of care and influence health care activitie ....Communicating to promote engagement in using electronic medical records. This reflexive ethnographic and co-design project aims to examine how patient and family participation occurs with health professionals in using the electronic medical record within hospitals, especially for patients with complex needs. Its significance involves working with patients and families to consider how they could take part in decision making activities across transitions of care and influence health care activities. Outcomes are new knowledge and practices about how communication occurs with the electronic medical record and strategies adopted for effective engagement. Benefits are increased understanding of how and under what circumstances, engagement can take place in using the electronic medical record.Read moreRead less
Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the ....Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the approach to image artefacts and image quantification. This project is expected to advance both single subject and population level biomedical imaging with greater accuracy and cost-effectiveness. This project also promotes explainable and generalisable artificial intelligence in medical imaging.Read moreRead less
Trails of migration out of Africa in harmful mutations of the First Peoples. This project aims to study harmful mutations specific to Indigenous populations. The process of migration out of Africa has left its footprints in the mutations present in world populations. By investigating these unique signatures, this project aims to characterise the harmful mutations specific to Aboriginal Australians using the whole genome sequences of the First Peoples. The expected outcomes will benefit future ....Trails of migration out of Africa in harmful mutations of the First Peoples. This project aims to study harmful mutations specific to Indigenous populations. The process of migration out of Africa has left its footprints in the mutations present in world populations. By investigating these unique signatures, this project aims to characterise the harmful mutations specific to Aboriginal Australians using the whole genome sequences of the First Peoples. The expected outcomes will benefit future Aboriginal health research to better understand the mutations associated with various genetic diseases.Read moreRead less
Dark-field: A new kind of x-ray imaging. This project aims to develop new x-ray imaging capabilities that look inside an object and map out those details that are too small to be seen directly, by extracting the dark-field which is produced as x-ray light scatters. Dark-field images can reveal tiny cracks in manufactured parts, discover powdered explosives or drugs during security screening, and detect changes in the size of the many tiny air sacs in the lungs. Expected outcomes of this project ....Dark-field: A new kind of x-ray imaging. This project aims to develop new x-ray imaging capabilities that look inside an object and map out those details that are too small to be seen directly, by extracting the dark-field which is produced as x-ray light scatters. Dark-field images can reveal tiny cracks in manufactured parts, discover powdered explosives or drugs during security screening, and detect changes in the size of the many tiny air sacs in the lungs. Expected outcomes of this project include new instruments and methods of analysis that will allow x-ray dark-field imaging to be quantitative and widely adopted. These methods should benefit non-invasive multi-scale imaging at the Australian Synchrotron and equip x-ray imaging in industry, security and healthcare.Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an i ....Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.Read moreRead less