Drug targets in malaria parasites. Malaria is rampant throughout our Region and hinders the economies of our neighbours reducing regional prosperity and stability. Australian security and aid personnel deployed in the Region contract malaria infections and global warming could bring malaria-carrying mosquitoes south to Sydney. Australia is pre-eminent in malaria research, making lead discoveries in vaccine and drug development. However, we lack crucial resources to study the parasite in the mo ....Drug targets in malaria parasites. Malaria is rampant throughout our Region and hinders the economies of our neighbours reducing regional prosperity and stability. Australian security and aid personnel deployed in the Region contract malaria infections and global warming could bring malaria-carrying mosquitoes south to Sydney. Australia is pre-eminent in malaria research, making lead discoveries in vaccine and drug development. However, we lack crucial resources to study the parasite in the mosquito phase of its life cycle. The Federation Fellowship will create a malaria mosquito facility to redress this crucial gap in our capability. The Fellowship will double as foreign aid investment by enhancing our capacity to protect ourselves as well as supporting our neighbours.Read moreRead less
The Role of Metals in the Biology of the Ageing Brain. Aims
1.To advance basic understanding of the interactions between cellular proteins and biologically important metals
2. To learn how these interactions change as the organism ages
3. To study the pathological results of aberrant metal biology using animal and cellular models of major age-dependent neurodegenerative disease.
In a rapidly ageing society, neurodegenerative disorders such as Alzheimer's and Parkinson's diseases will presen ....The Role of Metals in the Biology of the Ageing Brain. Aims
1.To advance basic understanding of the interactions between cellular proteins and biologically important metals
2. To learn how these interactions change as the organism ages
3. To study the pathological results of aberrant metal biology using animal and cellular models of major age-dependent neurodegenerative disease.
In a rapidly ageing society, neurodegenerative disorders such as Alzheimer's and Parkinson's diseases will present a medical and economic challenge demanding novel and powerful science. This research will lead both to deeper understanding of the basic mechanisms underlying such disorders and to tools for designing new and effective treatments.
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Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as b ....Biocompatible Ionic Liquids - Preserving Bioactive Structure and Function. A family of liquids recently discovered at Monash University has an ability to preserve bioactive molecules that represents a breakthrough in biotechnology. These new biocompatible ionic liquids will be investigated for applications in the treatment of diseases such as haemophilia. The ability of these liquids to stabilise a wide range of enzymes also opens up the potential of their use in a range of biosensors such as blood glucose monitors for diabetes management. In collaborations with research groups worldwide, these materials will also be applied to the preservation of bioactivity in applications including cryopreservation of endangered species such as coral and in medical therapeutics. Read moreRead less
Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between mar ....Genes to phenotype: Exploiting the marsupial model. This research will exploit one of Australia's finest natural resources, its marsupial fauna. The features of marsupial reproduction and development provide a unique opportunity to answer fundamental biological questions. This research will show how the minor differences in key developmental genes that have arisen in their 100 million year isolation give rise to the characteristic differences in developmental timing and reproduction between marsupials and other mammals. The focus on reproduction and development will also provide invaluable knowledge to underpin efforts to conserve our endangered species and to control those that are overabundant.Read moreRead less
Probing the Interface Between Polymeric Photonic Materials and Biology. This application provides a basis for Professor A. B. Holmes to develop a collaboration between the University of Melbourne (within the Bio21 Institute initiative) and CSIRO Division of Molecular Science to prepare novel plastics for electronics applications (lap top displays, transistors and solar cells) and to make specialised macromolecules for studying the way in which biological molecules may be made to recognise other ....Probing the Interface Between Polymeric Photonic Materials and Biology. This application provides a basis for Professor A. B. Holmes to develop a collaboration between the University of Melbourne (within the Bio21 Institute initiative) and CSIRO Division of Molecular Science to prepare novel plastics for electronics applications (lap top displays, transistors and solar cells) and to make specialised macromolecules for studying the way in which biological molecules may be made to recognise other molecules and thus change their function. It is envisaged that the multidisciplinary research collaboration will lead to commercial opportunities in "plastic electronics" and in human health such as the control of cancer and infectious diseases.Read moreRead less
Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborati ....Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborations to build a focus of excellence in Australian plant development research.
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Molecular control of apoptosis and protein homeostasis. A million cells are produced every second by cell division. At the same time a million cells commit suicide by a process called apoptosis. When cells fail to die when they should they can develop into cancers. In heart attacks, stroke and neurodegenerative diseases, many cells appear to activate their self destruct mechanism to die unnecessarily. Drugs that can cause cancer cells to kill themselves, or drugs that prevent cells dying when th ....Molecular control of apoptosis and protein homeostasis. A million cells are produced every second by cell division. At the same time a million cells commit suicide by a process called apoptosis. When cells fail to die when they should they can develop into cancers. In heart attacks, stroke and neurodegenerative diseases, many cells appear to activate their self destruct mechanism to die unnecessarily. Drugs that can cause cancer cells to kill themselves, or drugs that prevent cells dying when they shouldn't, would make a major impact on many important diseases. Understanding the molecular mechanisms of cell death is the first step towards developing these drugs.Read moreRead less