Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and corr ....Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.Read moreRead less
Diamond-based Ultra Violet (UV)-emitting devices. The development of UV-emitting solid state devices will enable new applications and drive rapid growth of new industries in particular in health care (sterilisation), microelectronics (lithography) and high-density data storage. With its deep expertise in photonics, Australia is well positioned to become a significant player in these industries. This collaborative project, involving academic and industrial partners, seeks to leverage Australian s ....Diamond-based Ultra Violet (UV)-emitting devices. The development of UV-emitting solid state devices will enable new applications and drive rapid growth of new industries in particular in health care (sterilisation), microelectronics (lithography) and high-density data storage. With its deep expertise in photonics, Australia is well positioned to become a significant player in these industries. This collaborative project, involving academic and industrial partners, seeks to leverage Australian scientific expertise to create new hybrid diamond/nitride structures potentially capable of emitting UV-radiation with high-efficiency and power. The outcomes will help seed new industry and economic growth in Australia.Read moreRead less
Optical supercontinuum generation from high pulse-energy optical sources. The aim of this project is to develop a broadband and high brightness optical fibre source based on optical supercontinuum generation (i.e. low-coherence optical signals with octave or more bandwidth). Unlike similar sources demonstrated recently which rely on expensive bulk femtosecond pump lasers, this source will be pumped by a large pulse-energy optical fibre laser and use stimulated Raman scattering to seed the contin ....Optical supercontinuum generation from high pulse-energy optical sources. The aim of this project is to develop a broadband and high brightness optical fibre source based on optical supercontinuum generation (i.e. low-coherence optical signals with octave or more bandwidth). Unlike similar sources demonstrated recently which rely on expensive bulk femtosecond pump lasers, this source will be pumped by a large pulse-energy optical fibre laser and use stimulated Raman scattering to seed the continuum generation. The primary outcome will be a compact low-cost all-fibre supercontinuum source with a wide range of applications in areas such as optical metrology, optical coherence tomography, and high resolution non-contact position and motion sensing.Read moreRead less
Development of electrical probes and advanced classification algorithms for early detection of cancer. The curable precursor of cervical cancer is cervical intra-epithelial neoplasia (CIN). Various cancer probes will be constructed for the identification of CIN based on electrical measurements on tissue. Through studies of the cellular structure and the junction between cells, a theoretical model of the electrode/mucus/tissue system will be developed at and below the surface of the tissue under ....Development of electrical probes and advanced classification algorithms for early detection of cancer. The curable precursor of cervical cancer is cervical intra-epithelial neoplasia (CIN). Various cancer probes will be constructed for the identification of CIN based on electrical measurements on tissue. Through studies of the cellular structure and the junction between cells, a theoretical model of the electrode/mucus/tissue system will be developed at and below the surface of the tissue under examination. Theoretical modelling, probe development and detection algorithms will be used to identify CIN in real-time with concurrently high sensitivity and specificity. Effective electrical probes for early detection of cancer (cervical, lung and breast) will be of enormous national and international benefit.Read moreRead less
Combined optical and electrical stimulation of auditory neurons. The bionic ear, which has now helped to improve the hearing of over 200,000 people worldwide, is a great example of Australian innovation success. This project aims to develop the fundamental technology that will underpin the next generation of these devices using a combination of infrared light and electrical signals to stimulate auditory nerves.
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Novel Early Warning System for Hypoglycaemia. An innovative technique will be developed for early detection of low blood glucose level (hypoglycaemia), a life-threatening complication affecting millions of people with Type 1 diabetes worldwide. Real-time analysis of the effectiveness of skin impedance, ECG (in particular heart rate and QT interval), and EEG (alpha wave) will be combined with robust adaptive neural networks to provide a novel theoretical and practical basis for developing a non-i ....Novel Early Warning System for Hypoglycaemia. An innovative technique will be developed for early detection of low blood glucose level (hypoglycaemia), a life-threatening complication affecting millions of people with Type 1 diabetes worldwide. Real-time analysis of the effectiveness of skin impedance, ECG (in particular heart rate and QT interval), and EEG (alpha wave) will be combined with robust adaptive neural networks to provide a novel theoretical and practical basis for developing a non-invasive hypoglycaemia monitor. This device has the potential to save lives, improve quality of life for people with diabetes and their carers, and put Australia at the forefront in this $US5 billion pa industry.Read moreRead less
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less
Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden o ....Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden of annually half a billion dollars on the Australian health budget. Controlling and reducing wear debris in prosthesis joints would reduce these costs and improve patients' quality of life.Read moreRead less
Non-invasive control of an implantable rotary blood pump used as a left ventricular assist device. The Holy Grail for developers of rotary blood pumps used as left ventricular assist devices is to control the pump to meet the body's metabolic demand and to do this without the need for implanting additional sensors. The controller must also detect and avoid dangerous states associated with over and under pumping.
In this research we will derive and implement a pump control algorithm that will ....Non-invasive control of an implantable rotary blood pump used as a left ventricular assist device. The Holy Grail for developers of rotary blood pumps used as left ventricular assist devices is to control the pump to meet the body's metabolic demand and to do this without the need for implanting additional sensors. The controller must also detect and avoid dangerous states associated with over and under pumping.
In this research we will derive and implement a pump control algorithm that will allow non-invasive prediction of pump flow, automatic detection of pumping states and adjustments for the metabolic demand of the body. The algorithms will be tested on the bench and in animal and human studies.Read moreRead less