Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management ....Improved methods for quantitation of acute phase proteins in biological samples. Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management of those at risk of heart attack, the single biggest contributor to healthcare costs in Australia. We further aim to adapt this technology to enable "point-of-care" assays that would help medical practitioners, especially in rural areas, to make informed diagnoses immediately.Read moreRead less
Novel biodiagnostic platforms for human metabolites. The innovative biosensor technologies developed in this project will be utilised at first by Australian athletes, enabling them to better monitor physiological conditions during training and thereby help maintain international competitiveness. Real-time sensing of lactate and other metabolites in athletes using advanced biomaterials coupled to frontier telemetry protocols for remote sensing will be extendable to bio-diagnostic needs in human h ....Novel biodiagnostic platforms for human metabolites. The innovative biosensor technologies developed in this project will be utilised at first by Australian athletes, enabling them to better monitor physiological conditions during training and thereby help maintain international competitiveness. Real-time sensing of lactate and other metabolites in athletes using advanced biomaterials coupled to frontier telemetry protocols for remote sensing will be extendable to bio-diagnostic needs in human health care and have significant social and economic benefits. Australia's international position in the application of interfacial science and nanomaterials for outcomes in biomedical engineering will be strengthened. Read moreRead less
Development of an implantable device to monitor lactate levels in blood: Monitoring the Performance of Australian athletes using Biosensor Technology. Sport is a critical area for social and economic investments. Novel medical monitoring systems using implantable biosensors will ensure optimal training programs for Australian athletes and maintain international competitiveness. Here we are developing a biosensor for real-time monitoring of lactate levels in athletes using frontier porous semicon ....Development of an implantable device to monitor lactate levels in blood: Monitoring the Performance of Australian athletes using Biosensor Technology. Sport is a critical area for social and economic investments. Novel medical monitoring systems using implantable biosensors will ensure optimal training programs for Australian athletes and maintain international competitiveness. Here we are developing a biosensor for real-time monitoring of lactate levels in athletes using frontier porous semiconductor technology and smart telemetry protocols to transfer the readings to a remote base unit. These highly innovative devices and the materials that they are made from have enormous commercial potential in biomedical engineering. There is a strong potential for Australia to have an important stake in this area by combining expertise in engineering, chemistry and nanostructured materials.Read moreRead less
Development of a novel flex sensor for use on catheters in medical pressure diagnostic tools. This research project will lead to a significant improvement on the technologies currently available to diagnostic tests of swallowing dysfunctions in children. The proposed technology is much needed and will enable future development of more direct and targeted interventions to assist with feeding based on these measurement techniques. In addition, the knowledge and expertise learned from this project ....Development of a novel flex sensor for use on catheters in medical pressure diagnostic tools. This research project will lead to a significant improvement on the technologies currently available to diagnostic tests of swallowing dysfunctions in children. The proposed technology is much needed and will enable future development of more direct and targeted interventions to assist with feeding based on these measurement techniques. In addition, the knowledge and expertise learned from this project as applied to such a miniature medical device comprises sufficient generic know-how to be useful in developing other biomedical devices. These developments will have a tangible technological impact in a way that will help the Australian biomedical industry be more competitive in the global market.Read moreRead less
Development of an endofunctional capsule for targeted delivery of biomarkers in the alimentary tract. The proposed capsule will provide a solution to the problem of accessing the small intestine for targeted delivery of biomarkers and drugs, and contribute to translational medical research to enhance our understanding of the function of the gut. Successful completion of this project will build on defined priority areas of research strength in Australia (frontier technologies, smart information u ....Development of an endofunctional capsule for targeted delivery of biomarkers in the alimentary tract. The proposed capsule will provide a solution to the problem of accessing the small intestine for targeted delivery of biomarkers and drugs, and contribute to translational medical research to enhance our understanding of the function of the gut. Successful completion of this project will build on defined priority areas of research strength in Australia (frontier technologies, smart information use) and assist in the provision of information critical to the design of novel in vivo endofunctional devices. The technologies to be developed in this project will be translatable to the development of other in vivo functional investigation and treatment devices. Read moreRead less
A single vaccine for influenza and pneumonia. Influenza and bacterial pneumonia collaborate to kill millions of people each year. This project aims to develop a single vaccine that will provide long-lasting protection against both influenza and pneumonia.
Development and evaluation of a remote monitoring system and its application to cardiac rehabilitation and occupational health. This project further develops and evaluates a system developed by the Industry Partner which permits real-time remote monitoring of a person's cardiac activity, position and velocity via GPS, and selected aspects of motion and posture using accelerometry. The study has three aims: to enhance the system's capacity for remote monitoring of human motion and physiology; to ....Development and evaluation of a remote monitoring system and its application to cardiac rehabilitation and occupational health. This project further develops and evaluates a system developed by the Industry Partner which permits real-time remote monitoring of a person's cardiac activity, position and velocity via GPS, and selected aspects of motion and posture using accelerometry. The study has three aims: to enhance the system's capacity for remote monitoring of human motion and physiology; to test its ability to support cardiac rehabilitation for those unable to access hospital-based programs; and to evaluate its application to the monitoring of workloads in physically demanding tasks associated with cardiovascular ill-health and musculoskeletal injury.Read moreRead less
The Development of High Power Cryo-Cooled Lasers and Their Application to Remote Sensing and Other Satelite-based Data Acquisition. We shall develop high power cryo-cooled lasers which will contribute directly to the national research priorities in Frontier Technologies and Safe Guarding Australia. In particular it will contribute to photonics, to remote sensing of the environment and to space based defence and surveillance applications. It will establish Australia as a pioneer in the field and ....The Development of High Power Cryo-Cooled Lasers and Their Application to Remote Sensing and Other Satelite-based Data Acquisition. We shall develop high power cryo-cooled lasers which will contribute directly to the national research priorities in Frontier Technologies and Safe Guarding Australia. In particular it will contribute to photonics, to remote sensing of the environment and to space based defence and surveillance applications. It will establish Australia as a pioneer in the field and generate important IP. It will be of benefit to Australian and international laser and defence industry, and it will be an ideal project for educating young laser physicists and engineers, of which there currently is a serious shortage in Australia.Read moreRead less
Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using tissue. Cancer is the second most common cause of death in Australia. The newly developed technology of Imaging Mass Spectrometry for peptides in tissue has the potential to discover biomarkers for early diagnosis of cancer. This new technology could avoid a number of cancer deaths and reduce suffering of patients through earlier and better diagnosis.
New developments in 3D electrical resistivity imaging of the shallow subsurface. This project is concerned with developing improved procedures for electrical imaging of hidden geological features in the subsurface. These techniques are required to solve urgent problems associated with important issues, such as natural hazards, disposal of dangerous waste, groundwater and construction of major buildings and tunnels. The project will develop new hardware, software and interpretation aids, as well ....New developments in 3D electrical resistivity imaging of the shallow subsurface. This project is concerned with developing improved procedures for electrical imaging of hidden geological features in the subsurface. These techniques are required to solve urgent problems associated with important issues, such as natural hazards, disposal of dangerous waste, groundwater and construction of major buildings and tunnels. The project will develop new hardware, software and interpretation aids, as well as providing postgraduate training in an area of vital national importance.Read moreRead less