Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
A single vaccine for influenza and pneumonia. Influenza and bacterial pneumonia collaborate to kill millions of people each year. This project aims to develop a single vaccine that will provide long-lasting protection against both influenza and pneumonia.
Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology ....Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology. Expected outcomes of this project include the development of a highly trained workforce and continued international collaboration in the field of high-technology sensor systems. This contribution to the GMT will provide significant benefits—it will change the way we view the Universe.Read moreRead less
A Laser Guide Star using a High Power, Synchronously Pumped Optical Parametric Oscillators. We will develop a novel high power source of 589nm coherent (laser) light to be used to create a laser guide star by exciting sodium atoms in the earth's upper atmosphere (the mesosphere). This is needed to determine the distortion caused by the atmosphere on an optical beam propagating through it and generate the information needed to correct those distortions using an adaptive optics telescope. This pr ....A Laser Guide Star using a High Power, Synchronously Pumped Optical Parametric Oscillators. We will develop a novel high power source of 589nm coherent (laser) light to be used to create a laser guide star by exciting sodium atoms in the earth's upper atmosphere (the mesosphere). This is needed to determine the distortion caused by the atmosphere on an optical beam propagating through it and generate the information needed to correct those distortions using an adaptive optics telescope. This project focuses on the development of a novel high power 589nm source based on a synchronously pumped optical parametric oscillator.Read moreRead less
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboratio ....Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboration with Australia's leading biotechnology industries. As a biotechnology industry project developing treatments for an emerging disease, it contributes to the national research priorities of Frontier technologies for building and transforming Australian industries, Promoting and maintaining good health and Safeguarding Australia.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Technologies for advanced optical fibre sensors. This project is to create a significantly better technology for exploration of oil and gas reserves under the ocean. Based on lasers and fibre optics, it leverages Australia's prodigious photonics expertise and couples it with Australia's established and well-regarded resource industry. Successful completion will enable better utilization of this country's natural resources, in particular oil and gas reserves, whilst also creating a high technolog ....Technologies for advanced optical fibre sensors. This project is to create a significantly better technology for exploration of oil and gas reserves under the ocean. Based on lasers and fibre optics, it leverages Australia's prodigious photonics expertise and couples it with Australia's established and well-regarded resource industry. Successful completion will enable better utilization of this country's natural resources, in particular oil and gas reserves, whilst also creating a high technology export, given the size of the world marine survey market (US$4 billion). Better energy exploration technologies are vital to Australia and, indeed the world, as energy supply dwindles and the increased energy costs begin to impact negatively on economic growth.Read moreRead less
Short-pulse laser cleaning for Australian heritage conservation. Conserving heritage objects is a demanding discipline, requiring a suite of techniques for different problems. Overseas, laser cleaning using long pulse techniques leaves microscopic damage as discrete chunks of material are removed, and is unsuitable for many materials. We have developed a short pulse laser process which can remove material molecule-by-molecule in a controlled fashion, and which can be readily halted once the fi ....Short-pulse laser cleaning for Australian heritage conservation. Conserving heritage objects is a demanding discipline, requiring a suite of techniques for different problems. Overseas, laser cleaning using long pulse techniques leaves microscopic damage as discrete chunks of material are removed, and is unsuitable for many materials. We have developed a short pulse laser process which can remove material molecule-by-molecule in a controlled fashion, and which can be readily halted once the final finish is achieved. We will research this technique for application to unique Australian heritage materials that are important to the specific conservation needs of the Australian War Memorial, the RAAF, Navy and Army Museums, Artlab Australia, and the Art Gallery of NSW.Read moreRead less