DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to und ....DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to understand and quantify factors influencing droplet deformation. Coupling non-Newtonian characteristics with microfluidic geometries will allow the continuous manufacture of micro-particles of specified size and shape for existing and new applications, and will provide guidance for further extending the process to nano-particle manufacture.Read moreRead less
Electro-viscous effects on pressure-driven liquid flow in microchannels. Australian biotechnology, information technology and food technology industries will benefit from the development of new tailored micro- and nano-fluidic devices for processing of non-Newtonian fluids. The efficiency of functional elements such as valves, pumps, mixers, reactors, heat exchangers can be optimised for specific fluids by understanding the coupling between the fluid properties, the device geometry, surface cha ....Electro-viscous effects on pressure-driven liquid flow in microchannels. Australian biotechnology, information technology and food technology industries will benefit from the development of new tailored micro- and nano-fluidic devices for processing of non-Newtonian fluids. The efficiency of functional elements such as valves, pumps, mixers, reactors, heat exchangers can be optimised for specific fluids by understanding the coupling between the fluid properties, the device geometry, surface charge, and the numerical predictions. This understanding will complement development in related projects on non-Newtonian drop and particle formation in microfluidic flows which envisage continuous particle manufacture for novel materials possessing programmable, enhanced functional properties.Read moreRead less
Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The underst ....Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The understanding gained can then be used to design biomimetic surfaces for use in health monitoring and medical diagnostic devices with improved sensitivity, robustness and portability, thereby providing significant benefits to the health sector.Read moreRead less
Simulating two-phase electrodynamic flows in droplet-based microfluidic circuit elements. The knowledge, data and analysis tools developed within this project will facilitate the economical production of electrodynamically controlled integrated droplet-based microfluidic devices for critical high-demand applications such as: genome sequencing; protein evolution, synthesis and crystallisation; micro-structured pharmaceuticals; disposable devices for biomedical analysis; portable point-of-entry (b ....Simulating two-phase electrodynamic flows in droplet-based microfluidic circuit elements. The knowledge, data and analysis tools developed within this project will facilitate the economical production of electrodynamically controlled integrated droplet-based microfluidic devices for critical high-demand applications such as: genome sequencing; protein evolution, synthesis and crystallisation; micro-structured pharmaceuticals; disposable devices for biomedical analysis; portable point-of-entry (biochem)security analysis devices. Hence this project is an investment in enabling technologies to benefit Australia's growing biotech, pharmaceutical and micro/nanotechnology sectors. Tangible community benefits (e.g., in improved diagnostic technologies, pharmaceuticals) will result.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775692
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Micro/nano optomechatronics sensing, measurement, and control research facility. This project aims to establish a facility that enhances the capabilities for sensing, positioning, and manipulating of micro/nano scale objects and environment, and as such constitutes the building block for many frontier technologies such as nanotechnology, bio/nano medicine, microsurgery and neurosurgery, biotechnology, microbiology, microfluidics, and micro/nano manufacturing, all of which are still in their infa ....Micro/nano optomechatronics sensing, measurement, and control research facility. This project aims to establish a facility that enhances the capabilities for sensing, positioning, and manipulating of micro/nano scale objects and environment, and as such constitutes the building block for many frontier technologies such as nanotechnology, bio/nano medicine, microsurgery and neurosurgery, biotechnology, microbiology, microfluidics, and micro/nano manufacturing, all of which are still in their infancy and promise to be the challenging areas of research for the next two decades. The outcomes will strengthen Australia's position in world-class innovative scientific research. It also strengthens collaboration between major engineering institutions and medical experts for innovative research and training of researchers.Read moreRead less
ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas ....ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas of human health through the regeneration of damaged nerves (eg. in spinal injury) and development of artificial muscles; in renewable energy (plastic solar cells, lightweight batteries and electronic textiles) and in sustainable industries (recovery of precious metals and new corrosion protection technologies).Read moreRead less
Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimen ....Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimensions similar to the scale of the probed biomolecules. The project turns 'up-side down' the challenge of invasive nano-probing of biomolecules using it in an engineered manner. The fundamental understanding of linear molecular motors will impact on biomedical science and on the assessment of hybrid natural-artificial dynamic nano-devices.Read moreRead less
Formation of Nanoporous titanium dioxide (TiO2) by Anodization of Titanium Thin Films. The development of nanoporous titanium dioxide (TiO2), with pore diameter less than 25 nm, represents a significant advance for both R&D and industrial applications. It is an invaluable material for the manufacture of a range of electronic and optical devices. These structures can be employed for the development of efficient thermoelectric coolers, highly sensitive biosensors as well as optical micro-devices w ....Formation of Nanoporous titanium dioxide (TiO2) by Anodization of Titanium Thin Films. The development of nanoporous titanium dioxide (TiO2), with pore diameter less than 25 nm, represents a significant advance for both R&D and industrial applications. It is an invaluable material for the manufacture of a range of electronic and optical devices. These structures can be employed for the development of efficient thermoelectric coolers, highly sensitive biosensors as well as optical micro-devices with high refractive index. In addition, nanoporous TiO2 has numerous applications in the fields of nanotechnology, bioengineering, diagnostics, materials science, and in the building industry. Australia will greatly benefit from the research and development of such a product with its promising market.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100985
Funder
Australian Research Council
Funding Amount
$427,116.00
Summary
Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous syst ....Shining a Light on Brain Temperature with Near-Infrared Nanosensors. This project aims to develop a contactless thermometry approach based on near-infrared fluorescence to map brain or nerve temperature in real-time. This research expects to generate new knowledge in the field of neuroscience using tools from optics, nanotechnology and materials science. The technique generated as a result of this project is expected to enable the quantification of the transient local heating of the nervous system in different situations and the study of how this affects neural function. This is expected to provide significant benefits, enabling the development of regulatory frameworks that ensure the safe implementation of new therapies for neurological and neurodegenerative disorders.Read moreRead less
Exploring the Dynamics of Nanostructure Self-Organisation during Compound Semiconductor Epitaxy. The application of LEEM to GaAs and InAs will be a world first, positioning Australia at the forefront of nanoscale self-organisation, leading to important international recognition and publicity. The spectacular movies obtained will revolutionise our basic understanding of compound semiconductor self-organisation and facilitate an improved control over nanostructure fabrication using MBE. This will ....Exploring the Dynamics of Nanostructure Self-Organisation during Compound Semiconductor Epitaxy. The application of LEEM to GaAs and InAs will be a world first, positioning Australia at the forefront of nanoscale self-organisation, leading to important international recognition and publicity. The spectacular movies obtained will revolutionise our basic understanding of compound semiconductor self-organisation and facilitate an improved control over nanostructure fabrication using MBE. This will generate entirely new device structures relevant to the frontier technologies of photonics and quantum information processing. The project will provide high level training for post-graduate and honours students in nanoscale characterisation and synchrotron science.Read moreRead less