Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453320
Funder
Australian Research Council
Funding Amount
$347,886.00
Summary
Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable ....Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable of full spectrum imaging. This new spectroscopic infrastructure will enable the knowledge-based development of new materials by allowing complete characterisation of structure-composition-property relationships at the nanometre level.Read moreRead less
Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum- ....Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum-related organic samples, including oil seeps from the ocean floor, and airborne particulates contributing to air pollution. The research will lead to a better understanding of geochemistry of petroleum-related materials and their potential impact on the environment and on public health.Read moreRead less
Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively ....Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively in tissues where adenosine is elevated. Whilst the development of drugs that protect against heart attack and stroke is a difficult and long term objective, any advances toward this goal would clearly be of great benefit to the community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989492
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Dynamic Texture Measurement Facility. A texture goniometer is an advanced tool for texture characterisation of steels, light alloys, nanomaterials, superconductors and minerals. The ability to conduct dynamic texture measurements will significantly enhance the effectiveness of four material-based research institutes at the University of Wollongong and at Deakin University, as well as collaborative research with BlueScope Steel. The research is directly aligned to the National Research Priority o ....Dynamic Texture Measurement Facility. A texture goniometer is an advanced tool for texture characterisation of steels, light alloys, nanomaterials, superconductors and minerals. The ability to conduct dynamic texture measurements will significantly enhance the effectiveness of four material-based research institutes at the University of Wollongong and at Deakin University, as well as collaborative research with BlueScope Steel. The research is directly aligned to the National Research Priority of Frontier Technologies for Building and Transforming Australian Industry. The equipment will provide a valuable resource for industries in the Illawarra region of NSW and in regional South-West Victoria.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less
Electron Emission from Diamond. Israel is emerging as an international hub of technology with one of the highest rates of R&D in the world. This collaborative project will access one of the world leading experts in diamond science and technology, Professor Alon Hoffman, to exploit the remarkable properties of diamond for a new generation of detectors and devices. Success in this project can lay the groundwork for tapping into the successful record of advanced technologies and venture capital fun ....Electron Emission from Diamond. Israel is emerging as an international hub of technology with one of the highest rates of R&D in the world. This collaborative project will access one of the world leading experts in diamond science and technology, Professor Alon Hoffman, to exploit the remarkable properties of diamond for a new generation of detectors and devices. Success in this project can lay the groundwork for tapping into the successful record of advanced technologies and venture capital funding that abound in Israel today. Read moreRead less
Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these so ....Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these societal needs and provide a new way to purify these important molecules. National and community benefits will accrue from this scientific innovation and from its application, which is expected to provide more efficient manufacturing opportunities for key biotechnology industries.Read moreRead less
Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins pro ....Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins produced by biotechnological procedures. The approach followed then allows these handles to be removed following isolation of the target protein. This project could thus lead to a considerable advance in the manufacture of recombinant proteins intended for human therapy.Read moreRead less