Robotic microsurgery: intra-operative measurement, modelling and micromanipulation control. This research will significantly improve microsurgery and minimally invasive surgery techniques, and further produce important benefits to medicine and healthcare. The project will also open new domains in the capabilities of modelling and control of complex systems with significant impact and benefits to numerous science and engineering practices.
Biomechanics Meets Robotics: Methods for Accurate and Fast Needle Targeting. This project intends to create a novel integrated framework for biomedical systems that can accurately target a needle. Accurate surgical targeting means less trauma and better patient outcomes. Needles are used in over half of all surgical procedures, but up to 38 per cent of these are affected by targeting errors. Achieving sub-millimetre accuracy is extremely difficult because inserting a needle displaces the tissue ....Biomechanics Meets Robotics: Methods for Accurate and Fast Needle Targeting. This project intends to create a novel integrated framework for biomedical systems that can accurately target a needle. Accurate surgical targeting means less trauma and better patient outcomes. Needles are used in over half of all surgical procedures, but up to 38 per cent of these are affected by targeting errors. Achieving sub-millimetre accuracy is extremely difficult because inserting a needle displaces the tissue and moves the target. How, then, can ultra-fine targeting be achieved? This project plans to integrate non-linear biomechanical models that predict tissue motion with accurate and principled motion control. It seeks to create new methods for surgical robots that will predict target motion and guide a needle to accurately intersect the target.Read moreRead less
A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on health ....A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety. Read moreRead less
Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer t ....Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer tissue state and morphology indirectly based on phase delay, speckle, and angle-resolved scattering. We will break new ground in correlating the structure and function of in situ epithelial tissue and cells to light scattering enabling, e.g., the detection of mitosis and apoptosis in cells buried in thick, turbid media, and of cancers and precancers in vivo.Read moreRead less
Neuroimage as biomechanical model: new real-time computational biomechanics of the brain. This project is to extend to medicine the success computational mechanics has enjoyed in traditional engineering. The project will create enabling modelling and computing technologies for Computer-Integrated Surgery Systems that could help to improve clinical outcomes and the efficiency of health care delivery.
Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currentl ....Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currently not possible. We also plan to make advances in the key area of scanning delay line technology by employing acousto-optics in OCT for the first time. Acousto-optics conveys advantages in no-moving-parts, scan-speed and accuracy.Read moreRead less
Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understandi ....Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understanding of cells, the building blocks of life. We will achieve this by: 1. Developing a microscope that combines microscopic resolution with rapid imaging; 2: Developing the capability to image both within the cell and its surrounding environment; and 3. Using our microscope to make discoveries in biology.Read moreRead less
Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silic ....Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silicon electrodes where irradiating with light causes an increase in conductivity at the illumination spot. The project will explore the variables that influence the spatial resolution and apply the ideas to making soft connects for nanoelectronics and making high density electrode arrays for electroanalysis.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
Biomechanical model-based algorithms for computational radiology of the brain. The proposed research will develop computational framework, which will allow matching high quality pre-operative brain images with lower resolution images taken during neurosurgery. The success of this work will greatly improve effectiveness of brain tumour removal, and therefore improve clinical outcomes. The proposed work will provide enabling technology for other areas of computer aided medicine, such as virtual re ....Biomechanical model-based algorithms for computational radiology of the brain. The proposed research will develop computational framework, which will allow matching high quality pre-operative brain images with lower resolution images taken during neurosurgery. The success of this work will greatly improve effectiveness of brain tumour removal, and therefore improve clinical outcomes. The proposed work will provide enabling technology for other areas of computer aided medicine, such as virtual reality operation planning systems with realistic force and tactile feedback, control systems of neurosurgical robots with tissue deformation prediction module, etc.Read moreRead less