Hybrid radiofrequency/optical catheter for effective atrial fibrillation ablation. This research project aims to advance engineering knowledge by applying an innovative, fibre-optics-based discrete optical coherence tomography to technology used for atrial fibrillation catheter ablation. RadioFrequency catheter-based ablation is far superior to cardiac drug therapy for atrial fibrillation patients. RadioFrequency catheters are not equipped with real-time lesion formation monitoring means, which ....Hybrid radiofrequency/optical catheter for effective atrial fibrillation ablation. This research project aims to advance engineering knowledge by applying an innovative, fibre-optics-based discrete optical coherence tomography to technology used for atrial fibrillation catheter ablation. RadioFrequency catheter-based ablation is far superior to cardiac drug therapy for atrial fibrillation patients. RadioFrequency catheters are not equipped with real-time lesion formation monitoring means, which enable the assessment of continuity-transmurality and prevent extra-cardiac complications, such as steam pops. Optical Coherece Tomography enables non-invasive, microscopic lesion formation assessment in real time during atrial fibrillation ablation procedures. The expected outcomes of this project are to develop a new hybrid fibre-optic/RadioFrequency catheter system and user-friendly driving software that will enable cardiac electrophysiologists to perform three key tasks not previously available.Read moreRead less
Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will signific ....Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will significantly benefit the mineral exploration industry as well as underwater detection of cables and ship wrecks.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Development of class-leading bioluminescence resonance energy transfer technologies for real-time monitoring of molecular interactions. The purpose of this project is to develop improved technologies for identifying and developing pharmaceuticals with fewer side effects. The expected outcome is the development of technologies that provide a level of sensitivity and data quality that enables adoption by the biotechnology and pharmaceutical industries.
Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Austral ....Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Australia, a low frequency electromagnetic survey system is one of the best methods to penetrate the cover and investigate deeper geological structures. The low frequency isolation system developed in this project will improve the survey instrument performance down to 4Hz, providing capability to explore resources about 50-100% deeper than existing instrumentation allows.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using tissue. Cancer is the second most common cause of death in Australia. The newly developed technology of Imaging Mass Spectrometry for peptides in tissue has the potential to discover biomarkers for early diagnosis of cancer. This new technology could avoid a number of cancer deaths and reduce suffering of patients through earlier and better diagnosis.
Functional proteomics of Giardia. This project will use the latest tools for dissecting and comparing genes and their protein products from one of the most common parasites infecting people, their pets, livestock and wildlife. This protozoan parasite Giardia is also of evolutionary and biological significance in terms of understanding the origin of higher animals from bacteria as well as fundamental questions about the parasitic way of life. Giardia proteins will be identified and characterised ....Functional proteomics of Giardia. This project will use the latest tools for dissecting and comparing genes and their protein products from one of the most common parasites infecting people, their pets, livestock and wildlife. This protozoan parasite Giardia is also of evolutionary and biological significance in terms of understanding the origin of higher animals from bacteria as well as fundamental questions about the parasitic way of life. Giardia proteins will be identified and characterised on the basis of their value in understanding disease processes and treatment, and by working with appropriate industry partners, proteins of commercial value will be exploited.Read moreRead less
High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and impro ....High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and improved environmental performance, the university team will focus on improved frequency stability, optimal tuning and novel vibration immunity techniques.
Achieving the project goals will broaden the international markets for the industry partner's products and lead to increased export income for Australia.
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