Space science and astronomy: New eyes on old stars: Decoding late-stage stellar evolution. Planetary nebulae, the extended shrouds of dying stars, are a fascinating, brief period in the life of most stars. Our Sun will eventually go through this phase engulfing the earth. Planetary nebulae are unique celestial laboratories thanks to their rich emission line spectra. They are amongst the most beautiful and mysterious of objects, whose startling images act as a photogenic magnet for public interes ....Space science and astronomy: New eyes on old stars: Decoding late-stage stellar evolution. Planetary nebulae, the extended shrouds of dying stars, are a fascinating, brief period in the life of most stars. Our Sun will eventually go through this phase engulfing the earth. Planetary nebulae are unique celestial laboratories thanks to their rich emission line spectra. They are amongst the most beautiful and mysterious of objects, whose startling images act as a photogenic magnet for public interest. Behind their beauty hides the mystery of how stars return carbon, one of life's essential building blocks - to interstellar space. This project will constitute the next major breakthrough in understanding these processes and addresses several significant astrophysical problems in the field via unique Australian data and instrumentation.Read moreRead less
Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will dete ....Supporting early science from the Murchison Widefield Array - a Square Kilometre Array (SKA) pathfinder telescope. The Murchison Widefield Array (MWA) is likely to be the first operational pathfinder for the $2.5 billion Square Kilometre Array (SKA) on one of the two candidate SKA sites - the Murchison Radioastronomy Observatory (MRO) in Western Australia. The MWA will therefore generate large volumes of scientific data before 2012, the expected date of the international decision that will determine whether Australia or South Africa is to host the SKA. The early science results from the MWA will showcase the excellence of the Australian site for radio astronomy and play a significant strategic role in Australia's bid to attract the SKA, as an international mega-science project to Australia, with its benefits to Australian science, industry and society.Read moreRead less
Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensi ....Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensitive, selective, fast and compact.Read moreRead less
Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise ....Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise to develop into new industries for Australia as well as to explore rich science opportunities at the boundaries of these disciplines.Read moreRead less
Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards be ....Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards better understanding of pathogen communication. Improved understanding of pathogen interactions should facilitate the development of novel anti-adhesives as therapeutics. Our project will train young scientists in a new integrated approach to biology.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obe ....Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obesity, immunity, fertility, neurological function and cancer. In the plant sphere, the outcomes will shed new light on plant functions related to plant energy metabolism, vitamin biosynthesis drought tolerance and water use by crops. The research will benefit both human health and agricultural food production and quality.Read moreRead less