Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower ....Probing the limits of Gravitational Force Sensing. This project will develop innovative laser measurement topologies for probing the limits of gravitational force sensing. Of particular interest is the detection of gravitational waves from astrophysical sources. Technology developed in this project will be able to see gravitational forces from slow moving mass at great distances away. Implementation of this technology will enhance the terrestrial gravitational wave detectors to observe at lower frequencies. This project will ensure Australia's continued involvement in the international Advanced LIGO (Laser Interferometer Gravitational Observatory) project and guarantee Australian participation in the first direct detection of gravitational waves.Read moreRead less
Tracking water on planetary surfaces using data from the Curiosity rover, the laboratory, meteorites and Australian field sites. A fundamental question in science is why does Earth have so much liquid water, but other planets do not? This project will answer this question using the Curiosity rover on Mars, studying alteration minerals that record the action of water. The project will develop new methods to improve our understanding of alteration minerals in martian meteorites, under controlled ....Tracking water on planetary surfaces using data from the Curiosity rover, the laboratory, meteorites and Australian field sites. A fundamental question in science is why does Earth have so much liquid water, but other planets do not? This project will answer this question using the Curiosity rover on Mars, studying alteration minerals that record the action of water. The project will develop new methods to improve our understanding of alteration minerals in martian meteorites, under controlled environmental conditions and in field samples that are relevant for Mars. It aims to build expertise in the environmental aspects of planetary surfaces and in novel instrumentation. This research will improve methods to examine returned extraterrestrial samples, to evaluate land degradation and to search for energy and ore deposits.Read moreRead less
Mechanisms of nucleation with special emphasis on gas hydrates. Successful recovery of natural gas from hydrate reservoirs, flow assurance in natural gas pipelines, prevention of undesirable dissociation of methane hydrates in deep ocean sediments, sequestration of carbon dioxide and high density gas storage, all depend on timely formation and dissociation of gas hydrates. Controlled extraction of methane hydrates from, and simultaneous sequestration of carbon dioxide to, deep ocean sediments ha ....Mechanisms of nucleation with special emphasis on gas hydrates. Successful recovery of natural gas from hydrate reservoirs, flow assurance in natural gas pipelines, prevention of undesirable dissociation of methane hydrates in deep ocean sediments, sequestration of carbon dioxide and high density gas storage, all depend on timely formation and dissociation of gas hydrates. Controlled extraction of methane hydrates from, and simultaneous sequestration of carbon dioxide to, deep ocean sediments have been considered to be the 'next big thing' in energy and environment sectors. Sequestration of carbon dioxide is necessary not only for reducing the greenhouse gases in the atmosphere but also to stabilise the sediments once methane is extracted.Read moreRead less
Better end-of-life care through an optimal, holistic regulatory framework. This project aims to enhance end-of-life care through better regulation. Current regulation does not work as intended and is complex and fragmented. This harms patients, families and health professionals, and wastes health resources across the 100,000 medical end-of-life decisions in Australia annually. Expected outcomes are: (1) the first study internationally to establish in practice how the interaction of conflicting l ....Better end-of-life care through an optimal, holistic regulatory framework. This project aims to enhance end-of-life care through better regulation. Current regulation does not work as intended and is complex and fragmented. This harms patients, families and health professionals, and wastes health resources across the 100,000 medical end-of-life decisions in Australia annually. Expected outcomes are: (1) the first study internationally to establish in practice how the interaction of conflicting law, policies, ethics and training affects the end-of-life care patients receive; and (2) a new holistic regulatory framework to enhance the quality of end-of-life care. Expected benefits are better palliative care, more patient involvement in decisions, reduced patient-doctor conflict and a more efficient health system.Read moreRead less
Bioreactors for manufacture of human platelets. Blood cell transfusion is a critical part of medicine that is supported by volunteer donors. Unfortunately, the demand for blood cells for transfusion far outstrips supply and therefore new strategies are required for manufacture of blood cells. This project will lead to the development of technology for manufacture of human platelets from stem cells. The systems devised will be applicable to a broad range of other blood cell types.
Mosquito-borne viruses - how they cause disease and novel approaches to prevention. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. This project has several national benefits. It will elucidate whether there is ....Mosquito-borne viruses - how they cause disease and novel approaches to prevention. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. This project has several national benefits. It will elucidate whether there is an association between RRV strain and the severity of disease and if there are human factors that affect the seriousness of symptoms. Knowledge of both of these could provide new avenues for the design of prevention and treatment strategies.Read moreRead less
Investigation of the structure and stability of ion tracks in application-specific materials and environments. This project will use an innovative experimental approach to study the structure and stability of high-energy ion tracks in solids. It will resolve open questions related to applications in geology, nanotechnology, and nuclear physics, and provide new strategies for understanding materials behaviour under extreme experimental conditions.
Mimetics and small chemical compounds for hemopoietic stem cell mobilisation. This project will result in the design and synthesis of new chemical compounds that could be used clinically to help collect blood stem cells for bone marrow transplantation. For patients this will mean more effective and less painful ways to collect stem cells and better transplant outcomes. There is a large, ongoing international market for this type of drug and likelihood of significant financial benefit.
Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normal ....Genetic control of tissue growth in animals. This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normally controlled and how it can be manipulated industrially. This should provide significant benefits, impacting stem cell biology (improving stem cell production), tissue engineering (improving growth of artificial tissues), veterinary science and agriculture (improving productivity).Read moreRead less
Soft nanotubes for biomedical applications. Nature employs self-assembly of small molecules to build complex materials. This project will mimic natural self-assemblies to design synthetic tubular structures on the nanoscale, and apply these nanostructures to solve problems in the fields of biology and medicine.