Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise ....Transformational diagnostics. Australia has established world-leading capabilities in optical fibres and surface science that, when brought together, have the potential to transform applications that require non-invasive, real-time and/or portable biological detection tools. We propose a novel and ambitious suite of projects that bring together these capabilities with experts in reproductive health, forensics and explosives to solve pressing problems in each of these areas that have the promise to develop into new industries for Australia as well as to explore rich science opportunities at the boundaries of these disciplines.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less