Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden o ....Rare isotopes as tracers of prosthesis debris. The incidence of knee replacement surgery in Australia is 30,000 per year. Limited by wear debris, the lifespan of knee implants is only 10-15 years and can be much shorter. Due to increasing life expectancy, many patients need several surgical procedures. As a multi-disciplinary team of materials-, isotope-tracing- and medical-experts, we aim to understand and monitor wear debris in prostheses. Knee replacement surgery alone imposes a high burden of annually half a billion dollars on the Australian health budget. Controlling and reducing wear debris in prosthesis joints would reduce these costs and improve patients' quality of life.Read moreRead less
Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them ....Fibre Optic Dosimeters for Medical and Environmental Applications. We will develop fibre optic dosimeters for environmental monitoring and radiation therapy. A novel approach using refractive index gradients will be used to capture scintillator light while rejecting noise. New knowledge will be gained of the mechanisms of radiation damage in scintillators and glasses. The small, flexible, accurate fibre optic dosimeters will be equivalent in absorbing characteristics to human tissue, making them superior to all currently available dosimeters. Fibre optic dosimeters will enable new adaptive radiotherapy techniques and provide quality assurance of dose delivery in radiotherapy. Their multiplexing capability will lead to applications in monitoring of workplaces and aerospace environments.Read moreRead less
Power scaling of remote plasma sources for gallium nitride film growth with real-time monitoring of activated nitrogen species. Domestic, industrial and community lighting currently accounts for ~20% of the world's overall energy consumption. Commonly used incandescent lights are based on inefficient, century-old technologies. In contrast, light emitting diodes (LEDs) use ~80% less energy and last ~100 times longer. LED deployment will bring substantial economic and environmental benefits for Au ....Power scaling of remote plasma sources for gallium nitride film growth with real-time monitoring of activated nitrogen species. Domestic, industrial and community lighting currently accounts for ~20% of the world's overall energy consumption. Commonly used incandescent lights are based on inefficient, century-old technologies. In contrast, light emitting diodes (LEDs) use ~80% less energy and last ~100 times longer. LED deployment will bring substantial economic and environmental benefits for Australia and globally. Next generation high-efficiency LEDs for lighting, will operate with reduced energy consumption, thus contributing to reaching future national targets for CO2 emission reduction. This project will achieve reduced production cost of a key LED material, and will support Australia's leadership in a growing global semiconductor manufacturing industry.Read moreRead less
Evaluating modern printing inks: the behaviour of charged particles in concentrated nonaqueous colloidal dispersions. The Partner Organisation in this proposal, Research Laboratories of Australia (RLA) is a small Adelaide-based company which is at the forefront of modern colour printing technology. RLA provides liquid toners to several major international manufacturers of colour printers for use in liquid immersion development processes. This proposal will develop an instrument for characterisin ....Evaluating modern printing inks: the behaviour of charged particles in concentrated nonaqueous colloidal dispersions. The Partner Organisation in this proposal, Research Laboratories of Australia (RLA) is a small Adelaide-based company which is at the forefront of modern colour printing technology. RLA provides liquid toners to several major international manufacturers of colour printers for use in liquid immersion development processes. This proposal will develop an instrument for characterising the properties of liquid inks, enabling continual R&D improvement of RLA's products. Furthermore, the instrument can be commercialised and marketed worldwide to companies dealing with concentrated colloidal dispersions in a wide range of industries including foods, pharmaceuticals, cosmetics and surface coatings.Read moreRead less
Cost effective high output polymer fibre optic lighting systems. A new flexible composite polymer can transport light over distances beyond 30 metres within diameters of 5mm to 25mm and still be intrinsically bright. The link between composition, transport efficiency and output will be established. Input studies will include tailored external optics and full integration of bright LED's inside the cable. Prototypes evaluated will include, lighting inside display refrigeration, "on person" safety ....Cost effective high output polymer fibre optic lighting systems. A new flexible composite polymer can transport light over distances beyond 30 metres within diameters of 5mm to 25mm and still be intrinsically bright. The link between composition, transport efficiency and output will be established. Input studies will include tailored external optics and full integration of bright LED's inside the cable. Prototypes evaluated will include, lighting inside display refrigeration, "on person" safety and fashion lighting (including novel jewellery), solar powered LED lighting for remote areas (including roadworks, stand alone signs, developing country and remote rural homes), daylight and lamps together in the one cable, and general lighting. Many of these will be developed by the industry collaborator.Read moreRead less
Fabrication of Magnesium Diboride (MgB2) thick films. The recent discovery of superconductivity at 39 K in MgB2 has stimulated considerable interest in terms of both fundamental research and applications. The purpose of the proposed project is to conduct fundamental studies on the synthesis, structures and microstructures, and physical properties of doped and undoped MgB2 thick films. The ultimate goal of this study is to fabricate high quality MgB2 thick films on different substrates and to gai ....Fabrication of Magnesium Diboride (MgB2) thick films. The recent discovery of superconductivity at 39 K in MgB2 has stimulated considerable interest in terms of both fundamental research and applications. The purpose of the proposed project is to conduct fundamental studies on the synthesis, structures and microstructures, and physical properties of doped and undoped MgB2 thick films. The ultimate goal of this study is to fabricate high quality MgB2 thick films on different substrates and to gain a better understanding of their various properties with a view to device application.Read moreRead less
The potential of biosolids and flyash mixtures for soil remediation for revegetation of degraded land. Revegetation of land that has been subjected to land clearing or mining is often limited by the poor quality or lack of topsoil. It may prove possible to remediate these areas of land by incorporating a mixture of two waste products, biosolids and flyash. The aim in this project is to determine the usefulness of this method of land remediation by investigating the nutrient levels and fate of co ....The potential of biosolids and flyash mixtures for soil remediation for revegetation of degraded land. Revegetation of land that has been subjected to land clearing or mining is often limited by the poor quality or lack of topsoil. It may prove possible to remediate these areas of land by incorporating a mixture of two waste products, biosolids and flyash. The aim in this project is to determine the usefulness of this method of land remediation by investigating the nutrient levels and fate of contaminants in various mixtures of biosolids and flyash materials, in the absence and presence of soil minerals, and soil ameliorants such as fertilizers and gypsum.Read moreRead less
Development of Low Cost, High Quality Nitrides for Solid-State Lighting and Other Power Saving Applications. The advent of high brightness, low cost, compact, low power white light-emitting diodes (LEDs) will revolutionise lighting as we currently know it. Incandescent light bulbs and fluorescent tubes are inefficient light sources and their replacement with high efficiency solid state LED lighting over the next 10 years will provide a 10% reduction in global greenhouse gas emissions. The develo ....Development of Low Cost, High Quality Nitrides for Solid-State Lighting and Other Power Saving Applications. The advent of high brightness, low cost, compact, low power white light-emitting diodes (LEDs) will revolutionise lighting as we currently know it. Incandescent light bulbs and fluorescent tubes are inefficient light sources and their replacement with high efficiency solid state LED lighting over the next 10 years will provide a 10% reduction in global greenhouse gas emissions. The development and enhancement of a recent Australian innovation for the fabrication of low cost high brightness LEDs will enable Australia to be at the frontier of this technology and to be a world leader in the next stage of its development.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these so ....Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these societal needs and provide a new way to purify these important molecules. National and community benefits will accrue from this scientific innovation and from its application, which is expected to provide more efficient manufacturing opportunities for key biotechnology industries.Read moreRead less