Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expecte ....Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expected outcomes include practical recommendations for improved professional standards, a rigorous building integrity system and a means for measuring change. Anticipated benefits include greater awareness by professions, trades and regulators of their role in in delivering the public goods of a trustworthy construction industry.Read moreRead less
The expanding disciplinary scope of research ethics committees: an inquiry into need and resistance. Do ethics committees have a bias toward quantitative and clinical research methods? Using a mixed methods approach, this project will systematically study whether ethics committees fail to understand and evaluate qualitative research methods; and whether some disciplines are more resistant to ethics review than others.
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Collective Obligations and Partial Compliance. The research I would conduct is likely to have considerable impact at both the national and international level. Despite the lack of systematic work on the issues my projects tackles, the importance of those issues is now widely recognized, and so work on them is likely to be widely noted and discussed. In addition, the research will have important implications for a number of the most prominent issues in contemporary life in Australia, such as issu ....Collective Obligations and Partial Compliance. The research I would conduct is likely to have considerable impact at both the national and international level. Despite the lack of systematic work on the issues my projects tackles, the importance of those issues is now widely recognized, and so work on them is likely to be widely noted and discussed. In addition, the research will have important implications for a number of the most prominent issues in contemporary life in Australia, such as issues concerning refugees, relations with the aboriginal community, and international aid.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and p ....Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and private sector organisations in Australia and New Zealand, the project intends to identify the factors that influence good and bad responses across a range of institutions; provide a clearer basis for reform of policies, procedures and law; and set benchmarks for comparative research worldwide.Read moreRead less
Police Leadership in the 21st Century: Redesigning Roles and Practices. Leaders are seen as exemplifying and guiding the climate of police organisations. This project will deliver comprehensive, comparative, and internationally relevant empirical data on the relationship between leaders' approach and behaviours and the achievement of outcomes in these significant, high profile public sector organisations. On this foundation the project will make recommendations on innovative institutional desi ....Police Leadership in the 21st Century: Redesigning Roles and Practices. Leaders are seen as exemplifying and guiding the climate of police organisations. This project will deliver comprehensive, comparative, and internationally relevant empirical data on the relationship between leaders' approach and behaviours and the achievement of outcomes in these significant, high profile public sector organisations. On this foundation the project will make recommendations on innovative institutional design to achieve ethical, effective and efficient policing capable of withstanding the challenges of the future. This will increase public confidence in policing, resulting in safer communities and improved crime control. This proposal contributes to the ARC research priority of Safeguarding Australia.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less