A single vaccine for influenza and pneumonia. Influenza and bacterial pneumonia collaborate to kill millions of people each year. This project aims to develop a single vaccine that will provide long-lasting protection against both influenza and pneumonia.
Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboratio ....Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboration with Australia's leading biotechnology industries. As a biotechnology industry project developing treatments for an emerging disease, it contributes to the national research priorities of Frontier technologies for building and transforming Australian industries, Promoting and maintaining good health and Safeguarding Australia.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Investment Approaches and Applications in Financial Markets: Evolutionary Kernel Based Subset Time-Series Using Semi-Parametric Approaches. The project will develop new investment assessments based on subset time-series modeling. Innovative evolutionary kernel smoothing algorithms using semi-parametric approaches will be introduced. The project will make three important applications of this modeling in financial markets: a) benchmarking and evaluation of inflation-indexed bonds; b) evaluation of ....Investment Approaches and Applications in Financial Markets: Evolutionary Kernel Based Subset Time-Series Using Semi-Parametric Approaches. The project will develop new investment assessments based on subset time-series modeling. Innovative evolutionary kernel smoothing algorithms using semi-parametric approaches will be introduced. The project will make three important applications of this modeling in financial markets: a) benchmarking and evaluation of inflation-indexed bonds; b) evaluation of the performance of global diversified investment funds; and c) prediction to provide early warning of the emergence of destabilising deflation or inflation. These three applications will lead to improved risk management practices and investment performance. Recursive algorithms will provide new statistical methods to study investment asset price movements and market volatility.
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Investment approaches and opportunities in renewable energy and financial resource markets, using semi-parametric approaches to evolutionary subset time-series lattice-ladder modelling. The project findings will help Australian exporters and importers understand and manage energy and resource price risks more effectively. The investment community will benefit through selecting optimal asset allocations and enhancing value to investors. It will also benefit many other agencies, particularly in th ....Investment approaches and opportunities in renewable energy and financial resource markets, using semi-parametric approaches to evolutionary subset time-series lattice-ladder modelling. The project findings will help Australian exporters and importers understand and manage energy and resource price risks more effectively. The investment community will benefit through selecting optimal asset allocations and enhancing value to investors. It will also benefit many other agencies, particularly in the service industries. It is not well recognised that in developed countries, including Australia, the financial service and related sectors account for more than 60 percent of economic activity and employment, so it is critical that more sophisticated statistical methods be established, and practical applications conducted, in order to advance the understanding of complexity management in the financial service and related sectors.Read moreRead less
The improvement of investment approaches by developing and applying bootstrap methods to innovative evolutionary kernel-based subset time-series modelling. With over $1 trillion of investors' monies in the hands of fund managers, the importance of efficient investment decisions across all industry sectors is self evident. Even if the modest target of systematically improving decision making by 1 or 2 % is set, the aggregate economic benefit achieved, given the compounding effects will be enormou ....The improvement of investment approaches by developing and applying bootstrap methods to innovative evolutionary kernel-based subset time-series modelling. With over $1 trillion of investors' monies in the hands of fund managers, the importance of efficient investment decisions across all industry sectors is self evident. Even if the modest target of systematically improving decision making by 1 or 2 % is set, the aggregate economic benefit achieved, given the compounding effects will be enormous. Any developed or developing country will profit from such advanced decision-making approaches. Therefore it is critical that more sophisticated statistical methods be established, and practical applications conducted, in order to advance the understanding of complexity management in the financial investment and other relevant sectors.Read moreRead less
Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to un ....Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to understanding the development and evolution of geological basins and the sediments that fill them. The models will be integrated with available offshore data for potentially prospective Australian basins in the Northwest Shelf and the Southern Australian margin.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less