Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Design of a Reference Methodology for Extended Enterprise Architecture. Enterprises have nowadays a very critical perception of the actual benefits of Information Technology (IT). Significant investments in IT infrastructures have been made. However, in many cases no monetary benefits could be demonstrated. Enterprises Architectures provide a way to link the business and the IT perspective. This project aims to develop an operational methodology with a solid theoretical foundation for the design ....Design of a Reference Methodology for Extended Enterprise Architecture. Enterprises have nowadays a very critical perception of the actual benefits of Information Technology (IT). Significant investments in IT infrastructures have been made. However, in many cases no monetary benefits could be demonstrated. Enterprises Architectures provide a way to link the business and the IT perspective. This project aims to develop an operational methodology with a solid theoretical foundation for the design of such Enterprise Architectures. The outcomes and the innovation of this project are an extension of the popular Zachman Framework. Integrated modelling techniques proposed within the Architecture of Integrated Information Systems will be used to populate this framework.Read moreRead less
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less
Understanding and mitigating nitrous oxide emission from wastewater treatment plants. Climate change caused by greenhouse gas emissions is one of the most serious challenges that mankind is facing. Substantial reduction in emissions must be achieved, with responsibility to be shared by all industrial sectors. Wastewater systems contribute to greenhouse gas emissions through not only energy consumptions but also direct emissions of fugitive greenhouse gases such as nitrous oxide. This project aim ....Understanding and mitigating nitrous oxide emission from wastewater treatment plants. Climate change caused by greenhouse gas emissions is one of the most serious challenges that mankind is facing. Substantial reduction in emissions must be achieved, with responsibility to be shared by all industrial sectors. Wastewater systems contribute to greenhouse gas emissions through not only energy consumptions but also direct emissions of fugitive greenhouse gases such as nitrous oxide. This project aims to provide knowledge and technology support to the Australian wastewater industry to minimize the emission of nitrous oxide during biological nitrogen removal from wastewater. This is critically important for this industry to achieve greenhouse gas neutral wastewater management.Read moreRead less
Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Methane and nitrous oxide emissions from sewers – understanding, modelling and mitigation. The research and industry partners will collaborate on this project to quantify, understand and mitigate emissions of methane and nitrous oxide in sewer networks. Both methane and nitrous oxide are potent greenhouse gases, and their emissions need to be accounted for and mitigated for the water industry to achieve greenhouse neutral water services.
Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management proto ....Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management protocols for tick-borne disease in Australia.Read moreRead less
Development of Canonical Mist Filter Models. Over one million tonnes of oil (mist) is wasted every year – and emitted to the atmosphere through inefficient filtration. Over 50 per cent of energy usage in most process industries is for filtration and separation processes, yet mist filters and separators are largely designed by trial and error, resulting in sub-optimal, inefficient designs. Recent advances by the research team have, only now, made it possible to develop accurate models for such sy ....Development of Canonical Mist Filter Models. Over one million tonnes of oil (mist) is wasted every year – and emitted to the atmosphere through inefficient filtration. Over 50 per cent of energy usage in most process industries is for filtration and separation processes, yet mist filters and separators are largely designed by trial and error, resulting in sub-optimal, inefficient designs. Recent advances by the research team have, only now, made it possible to develop accurate models for such systems. This work intends to be the first to develop accurate, broadly applicable models for all processes in mist filters, thereby providing immense process efficiency benefits, together with improved worker and environmental protection, and less wastage of dwindling oil resources.Read moreRead less