Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements ....Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements, his project aims to determine the number of Auger electrons per nuclear decay accurately for medical isotopes. The outcome will be accurate dose data for radioisotopes, plus essential knowledge to develop new cancer treatments based on Auger electrons, which target a fraction of a cell.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Synchrotron radiation techniques applied to melting and resolidification at a nanometric scale. By delivering underpinning knowledge of melting characteristics of nanoparticles, the proposal seeks results that can lead to breakthrough applications in advanced materials engineering. Measurements of the liquid nanoparticle structure performed at the Australian Synchrotron are unprecedented and are thus likely to include the development of new methodology. National and international exposure of Aus ....Synchrotron radiation techniques applied to melting and resolidification at a nanometric scale. By delivering underpinning knowledge of melting characteristics of nanoparticles, the proposal seeks results that can lead to breakthrough applications in advanced materials engineering. Measurements of the liquid nanoparticle structure performed at the Australian Synchrotron are unprecedented and are thus likely to include the development of new methodology. National and international exposure of Australian science and the Australian Synchrotron will have both scientific and economic ramifications. Involvement of students will contribute to developing the local synchrotron knowledge base and is beneficial to the Australian synchrotron-research community as a whole.Read moreRead less
Photonic Crystal Quantum Dot Lasers. Nanotechnology is expected to make a major impact in all industry sectors. This research has the potential to develop patentable technologies of interest to Australian industries in the fields of computers, communications, defence, environmental and medical sensing. This project will enhance Australia's international links with UK, France, Canada, Korea and USA and allow us to train skilled personnel essential for the development of high tech industries in ....Photonic Crystal Quantum Dot Lasers. Nanotechnology is expected to make a major impact in all industry sectors. This research has the potential to develop patentable technologies of interest to Australian industries in the fields of computers, communications, defence, environmental and medical sensing. This project will enhance Australia's international links with UK, France, Canada, Korea and USA and allow us to train skilled personnel essential for the development of high tech industries in Australia. Read moreRead less
Feedback Processes in Galaxy Formation. We have an opportunity to combine the best Australian theory with the best local and international telescopes, to probe the murky story of how galaxies form and why they look they way they do today. By looking back to a time when the Universe was only 1 billion years old, and comparing what we see with cutting edge supercomputer simulations plus pure theory, we will gain insight into the birth of entire galaxies. The results will form part of the study o ....Feedback Processes in Galaxy Formation. We have an opportunity to combine the best Australian theory with the best local and international telescopes, to probe the murky story of how galaxies form and why they look they way they do today. By looking back to a time when the Universe was only 1 billion years old, and comparing what we see with cutting edge supercomputer simulations plus pure theory, we will gain insight into the birth of entire galaxies. The results will form part of the study of how the universe works - that is driving astrophysics today, and represents pure research for the sake of advancing knowledge and showing us where we fit into the Universe. In doing so we will also advance Australia's base of theoretical and computational expertise.Read moreRead less
Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres ....Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres in the brain, to collect and reconstruct images. The project is expected to reduce dMRI scan times and ultimately make non-invasive and inexpensive early detection of neurological disorders such as dementia feasible.Read moreRead less
Beyond metamaterials: new composites for transforming photonics. Composites containing metamaterials, new materials with extraordinary electromagnetic properties, are opening new horizons in optical physics, with the potential to deliver a range of unprecedented functionalities. This project will clarify the exotic physics of these revolutionary new materials, leading to new photonics applications.
The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Austr ....The role of neutral amino acid transport in normal physiology. Future benefits of these studies include the Promotion and Maintenance of Good Health achieved by providing: (1) a better understanding of brain and balance disorders; (2) insights into the damaging effects of the sun and; (3) existing neonatal screening programmes for Hartnup disorder with greater scientific foundation regarding the implications of inheriting this condition, including dietary advce. We will be able to provide Australians who inherit Hartnup disorder with a better understanding of this disease by enabling individuals and families to make choices that lead to healthy, productive and fulfilling lives.Read moreRead less
Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Using high-resolution lasers to test quantum electrodynamics. High-precision laser-based measurements of atomic and molecular structure are benchmarks for our fundamental understanding of matter. This project will undertake state-of-the-art experiments on atomic helium, to test and challenge current theoretical predictions of fundamental quantum-electrodynamic properties for helium and for more complex atoms.