A programme to study quarkonium-like states at ATLAS. Particle physics, the study of the fundamental building blocks of matter, has pioneered the use of large collaborations --- hundreds of scientists working in dozens of countries --- to solve difficult research problems. Australian groups have contributed to several such experiments, studying cosmic rays, neutrinos, and broken symmetries, as well as developing ATLAS, a vast experiment dedicated to understanding the origin of mass. This projec ....A programme to study quarkonium-like states at ATLAS. Particle physics, the study of the fundamental building blocks of matter, has pioneered the use of large collaborations --- hundreds of scientists working in dozens of countries --- to solve difficult research problems. Australian groups have contributed to several such experiments, studying cosmic rays, neutrinos, and broken symmetries, as well as developing ATLAS, a vast experiment dedicated to understanding the origin of mass. This project seeks to use ATLAS for a new purpose: searching for exotic mesons. Our existing commitment to ATLAS provides an opportunity to develop this as a new avenue of fundamental research in this country.Read moreRead less
Field Statistics of Space and Astrophysical Phenomena. Waves and radiation typically occur in bursts and persist, with their driving particle distributions, for unexpectedly long distances in space and astrophysical sources. These features cannot be accounted for with older plasma theory but are explained naturally with stochastic growth theory (SGT). Recent observations show SGT to be widely applicable in space and for pulsars. We propose to make SGT into a quantitative dynamic theory tested on ....Field Statistics of Space and Astrophysical Phenomena. Waves and radiation typically occur in bursts and persist, with their driving particle distributions, for unexpectedly long distances in space and astrophysical sources. These features cannot be accounted for with older plasma theory but are explained naturally with stochastic growth theory (SGT). Recent observations show SGT to be widely applicable in space and for pulsars. We propose to make SGT into a quantitative dynamic theory tested on known SGT systems, to discover and interpret field statistics of natural radio emissions, and to develop and test observationally theories based on SGT and associated wave/radiation processes for key space and astrophysical phenomena.Read moreRead less
The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and ....The basis of recognition and disposal of dysfunctional proteins by clusterin. When proteins become damaged they can precipitate. A blood protein called clusterin prevents precipitation of damaged proteins. Clusterin does this by forming complexes with the damaged proteins. Clusterin is the first blood protein known to do this. We will discover which parts of clusterin are responsible for this activity. We will also discover whether cells can take up and dispose of the complexes of clusterin and damaged proteins. This work is important because some diseases (eg, Alzheimers disease) involve the toxic effects of abnormal protein precipitation. Understanding how clusterin works may help in developing better treatments for these diseases.Read moreRead less
Wave Localization and Burstiness in Type III Solar Radio Bursts. The project will raise Australia's scientific standing and expertise in space and plasma physics, space weather, and complex systems due to new discoveries, theories, publications, and invited talks. It supports Australia's involvement in NASA's $600M STEREO mission and other space efforts, and greatly leverages Australia's small numbers and budget on the world stage. The project will enhance Australia's human capital due to high-l ....Wave Localization and Burstiness in Type III Solar Radio Bursts. The project will raise Australia's scientific standing and expertise in space and plasma physics, space weather, and complex systems due to new discoveries, theories, publications, and invited talks. It supports Australia's involvement in NASA's $600M STEREO mission and other space efforts, and greatly leverages Australia's small numbers and budget on the world stage. The project will enhance Australia's human capital due to high-level training and increased expertise of new staff, students, and CIs. The new data and methods will develop, better exploit, and make more competitive Australia's scientific infrastructure. Last, the exciting discoveries expected will attract the international media and increase science's appeal to the public.Read moreRead less
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less
Natural Product-derived Proteomics Probes for Specific Detection of Protein Kinase C Activities. Better health care depends on how well diseases are understood and how accurately disease analysis and diagnosis can be carried out. This is not only important to disease treatment but also prevention. This project will first generate new compounds that could have improved therapeutic value in cancer treatment. In addition, these compounds will be further engineered to provide a new technology of ....Natural Product-derived Proteomics Probes for Specific Detection of Protein Kinase C Activities. Better health care depends on how well diseases are understood and how accurately disease analysis and diagnosis can be carried out. This is not only important to disease treatment but also prevention. This project will first generate new compounds that could have improved therapeutic value in cancer treatment. In addition, these compounds will be further engineered to provide a new technology of tracing the molecular signature of diseases such as cancer for early detection and better preventative care and treatment. This will create new economic advantage and contributes to the transformation of Australian health care industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238884
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to ....Development of the CANGAROO III Very High Energy Gamma-ray telescope. This international project will explore the only part of the electromagnetic spectrum yet to be subjected to detailed astronomical study. CANGAROO III will span the energy range from ~100GeV to >10TeV, expanding upwards the range of satellite observations, and downwards the range accessible from previous ground-based systems. Gamma-ray observations have opened a new window on the universe and it is clear that there is much to be discovered with this new instrument. This project will provide an Australian infrastructure contribution to support the multi-million dollar contribution of our Japanese partners, and thus provide Australian access to a key astrophysical field at very modest cost.Read moreRead less
Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development o ....Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of isoflavone metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development ....Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of phytoestrogen metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less