Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
The Role of Naturalism in Ontology and Scientific Methodology. Naturalism is the philosophical doctrine perhaps best described as a respect for the methods of the natural sciences. Although most contemporary philosophers would describe themselves as naturalists, exactly how this important doctrine is spelled out is a matter of much controversy. What is more, many substantial issues in both philosophy of science and in metaphysics depend crucially on how we understand naturalism. This project ....The Role of Naturalism in Ontology and Scientific Methodology. Naturalism is the philosophical doctrine perhaps best described as a respect for the methods of the natural sciences. Although most contemporary philosophers would describe themselves as naturalists, exactly how this important doctrine is spelled out is a matter of much controversy. What is more, many substantial issues in both philosophy of science and in metaphysics depend crucially on how we understand naturalism. This project will investigate the various conceptions of naturalism, looking at both their motivations and their implications for philosophy and scientific and mathematical methodology.Read moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be ....Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be renewed.Read moreRead less
Rapid decisions: from neuroscience to complex cognitions. A succession of rapid decisions supports our daily life - run or walk? Fish or steak? This project will integrate three different approaches to understanding these decisions, from neuroscience, mathematical psychology and experimental psychology. This research will provide insights about normal human functioning, and problems such as occur in healthy ageing.
On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technol ....On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technology is expected to provide new capability in bioanalysis, proteomics and rapid clinical diagnostics. Future benefits may include new commercial fibre based technologies which could be applied within industrial and clinical laboratories within the next ten years.Read moreRead less
Quantitative psychological theories for a dynamic world. . The dynamic world around us means we need to constantly adjust our decisions in light of ever-changing influences, both external (weather, traffic ...) and internal (fatigue, learning ...). This project aims to understand how these changes affect performance. This will have significance for basic science, and also practical benefits for applied psychology. This project will examine the dynamic nature of psychological processes in a range ....Quantitative psychological theories for a dynamic world. . The dynamic world around us means we need to constantly adjust our decisions in light of ever-changing influences, both external (weather, traffic ...) and internal (fatigue, learning ...). This project aims to understand how these changes affect performance. This will have significance for basic science, and also practical benefits for applied psychology. This project will examine the dynamic nature of psychological processes in a range of settings: simple decisions, consumer decisions, human-machine interactions, and team performance. Theory development will lead to improved understanding of underlying cognitive processes, and transforms the measurement of decisions, which is important for applied psychological investigations. Read moreRead less
How isolated is Antarctica? Assessing past and present plant colonisations. The project aims to assess how biologically isolated Antarctica is by discovering how, when and where natural colonisations of the continent have occurred. The research will focus on mosses, the dominant plant group in the Antarctic. genomic tools will be combined with environmental, spatial, and ecological data to assess mechanisms and directions of dispersal to and around Antarctica, and to predict areas most likely to ....How isolated is Antarctica? Assessing past and present plant colonisations. The project aims to assess how biologically isolated Antarctica is by discovering how, when and where natural colonisations of the continent have occurred. The research will focus on mosses, the dominant plant group in the Antarctic. genomic tools will be combined with environmental, spatial, and ecological data to assess mechanisms and directions of dispersal to and around Antarctica, and to predict areas most likely to be colonised in the future. This will help understand the processes underpinning the evolution and diversity of Antarctic species, and the vulnerability and adaptability of Antarctic ecosystems. Read moreRead less