3D printing of custom musical instruments for heritage and industry needs. This Project will explore innovative heritage and commercial applications for the 3D modelling and printing of custom musical instruments to advance Australia’s flexible-manufacturing industry. Musical instruments are complex devices, often made with multiple parts and/or materials, that are commonly built to produce sound through a multitude of manufacturing processes to meet high-performance requirements. When hand-craf ....3D printing of custom musical instruments for heritage and industry needs. This Project will explore innovative heritage and commercial applications for the 3D modelling and printing of custom musical instruments to advance Australia’s flexible-manufacturing industry. Musical instruments are complex devices, often made with multiple parts and/or materials, that are commonly built to produce sound through a multitude of manufacturing processes to meet high-performance requirements. When hand-crafted, they can present considerable morphological variations, even within a single instrument type. The Project’s novel challenge of flexibly manufacturing custom music instruments to meet a diversity of end-user needs will create new digital heritage strategies and market opportunities for Australian research end-users.Read moreRead less
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Investing in Aboriginal Languages. We will develop the first systematic account of Aboriginal language programs and what makes them effective and sustainable. The project will create a substantial evidence base, leading to a comprehensive model of language revitalisation and how it operates in each place, and for whom. The model will show how local and national organisations can invest in Aboriginal languages, and what kinds of returns they can expect. The project involves a two-way collaboratio ....Investing in Aboriginal Languages. We will develop the first systematic account of Aboriginal language programs and what makes them effective and sustainable. The project will create a substantial evidence base, leading to a comprehensive model of language revitalisation and how it operates in each place, and for whom. The model will show how local and national organisations can invest in Aboriginal languages, and what kinds of returns they can expect. The project involves a two-way collaboration with Aboriginal people across the country that will elevate their voices and build their capacity for designing and evaluating programs, businesses and technologies for keeping Aboriginal languages strong.Read moreRead less
Virtual Galleries: new media technologies to influence livelihood and arts participation in remote communities of the Northern Territory, Australia. The Virtual Galleries project addresses the issue of limited economic development in remote communities by introducing a user-controlled webcam and interactive 3-D (three-dimensional) Art Galleries into remote art centres to help people in remote communities to secure an income and create wealth and social wellbeing for themselves, their families an ....Virtual Galleries: new media technologies to influence livelihood and arts participation in remote communities of the Northern Territory, Australia. The Virtual Galleries project addresses the issue of limited economic development in remote communities by introducing a user-controlled webcam and interactive 3-D (three-dimensional) Art Galleries into remote art centres to help people in remote communities to secure an income and create wealth and social wellbeing for themselves, their families and their communities.Read moreRead less
Immunising Aboriginal Mothers With Pneumococcal Polysaccharide Vaccine To Prevent Infant Ear Disease And Carriage
Funder
National Health and Medical Research Council
Funding Amount
$1,131,530.00
Summary
Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are nee ....Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are needed to eliminate, or at least delay, this early-onset pneumococcal colonisation. One such strategy is the administration to the mother of pneumococcal vaccine, which may protect the newborn infant by leading to higher titres of transplacental or breast milk pneumococcal antibodies and-or by reducing carriage (and transmission to the infant) of maternal pneumococci. Previous small studies using this strategy have been encouraging, but there have been no studies properly evaluating carriage or disease endpoints in infants. The polysaccharide pneumococcal vaccine is currently recommended for all Aboriginal and Torres Islander persons aged 15 years or more in the Northern Territory but uptake of the vaccine has been poor. We propose to conduct a pilot study to determine if maternal immunisation with this vaccine, either in the third trimester of pregancy of immediately following delivery, can reduce pneumococcal carriage and the prevalence of middle ear disease among Aboriginal infants at seven months of age. We aim to recruit 210 Aboriginal women who have uncomplicated pregnancies from Darwin and remote communities in the Top End of the Northern Territory. Each subject and their infant offspring will be followed-up after vaccination and at birth, one , two and seven months after birth.Read moreRead less
Digital noticeboards for remote Aboriginal communities: bringing web 2.0 participation to non-western cultures with low English and technical literacy. Remote Aboriginal communities suffer from geographic and cultural isolation. Web 2.0 offers a solution yet is ill-suited to traditional collective cultures, those with low English and technical literacy, and the poor. This project will produce novel public web-enabled touchscreen noticeboards and table tops suited to traditional cultures.
Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintr ....Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintroducing three mammal species to a critically endangered temperate woodland: a carnivore (the eastern quoll), an insectivore (yellow-footed antechinus), and a herbivore (the eastern chestnut mouse). Results from this sequenced multi-species reintroduction experiment will have broad applicability to ecosystem restoration in Australia and overseas.Read moreRead less
Integrating fire and predator management to conserve threatened species. This project aims to empower land managers to better conserve Australia’s threatened native animals by developing decision-support approaches that facilitate integrated management of threatening processes. The project will use a combination of novel predictive models, field experiments and data syntheses to assist land managers to better conserve Australia’s threatened native fauna. This project will benefit biodiversity co ....Integrating fire and predator management to conserve threatened species. This project aims to empower land managers to better conserve Australia’s threatened native animals by developing decision-support approaches that facilitate integrated management of threatening processes. The project will use a combination of novel predictive models, field experiments and data syntheses to assist land managers to better conserve Australia’s threatened native fauna. This project will benefit biodiversity conservation by enabling more effective allocation of limited conservation resources.Read moreRead less