Discovery Early Career Researcher Award - Grant ID: DE190100609
Funder
Australian Research Council
Funding Amount
$368,000.00
Summary
Mechanobiology: a new model of integrin activation by membrane tension. This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super reso ....Mechanobiology: a new model of integrin activation by membrane tension. This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super resolution microscopy, microfluidics and molecular dynamics simulations. It is expected that the role of membrane tension in promoting cell adhesion will be defined at molecular scale, and the link between integrin activation and Piezo calcium channel mediated membrane tension sensing will be delineated.Read moreRead less
Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed t ....Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed to establish the properties of the electric fields around cells and cell membrane interactions with these fields that enable molecular translocation. This fundamental science could have broad implications in the domains of drug delivery, gene therapy and neural stimulation.Read moreRead less
Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and technique ....Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and techniques in the fields of reactive polymer synthesis, functional membrane fabrication and application in bioseparation. The innovative membranes developed in the project are able to improve the production capacity of therapeutic protein manufacturing processes, providing significant economic benefits to Australia.Read moreRead less
Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective mole ....Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective molecule transport. The membranes developed in the project have great potentials for improving the production capacity and sustainability of Australian industries, e.g., pharmaceutical manufacturing, bioethanol production and petroleum refining, providing significant economic and environmental benefits to Australia.Read moreRead less
Crystal engineering of membranes for chiral separation . This project addresses the urgent challenge of chiral separation in the manufacturing of pharmaceuticals and agrochemicals by creating a new class of membranes produced by engineering functionalised porous framework crystals. This project expects to generate new knowledge regarding how membrane chemistry and architecture can be used to achieve highly selective, fast chiral molecule transport. The expected outcomes of the project include ne ....Crystal engineering of membranes for chiral separation . This project addresses the urgent challenge of chiral separation in the manufacturing of pharmaceuticals and agrochemicals by creating a new class of membranes produced by engineering functionalised porous framework crystals. This project expects to generate new knowledge regarding how membrane chemistry and architecture can be used to achieve highly selective, fast chiral molecule transport. The expected outcomes of the project include new membrane compositions, design principles, fabrication techniques, and proof-of-concept production of scalable, high-performance composite membranes. This project should produce significant economic and environmental benefits in the development of advanced membranes, pharmaceuticals, and agrochemicals.Read moreRead less
Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new ....Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new applications and to value-add Australia’s advanced manufacturing industry, presenting new opportunities for Australian MedTech industries with innovative, disruptive technologies to address its unique needs and to claim Australia’s position within the competitive global market.Read moreRead less
Novel hybrid silica membranes for desalination. This project aims to produce high flux, highly stable ceramic membranes for use in desalination. This will result in novel, low energy desalination processes, delivering potable water at a greatly reduced cost.
Discovery Early Career Researcher Award - Grant ID: DE150101687
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of ....Nanostructure Tailoring of Inorganic Membranes by Rapid Thermal Processing. This project aims to produce inorganic membranes with desired nanostructures using a Rapid Thermal Processing (RTP) technique for gas separation applications. The key concept of the research is that the RTP will be able to achieve thin-film membrane layer with a finer microstructure and pore size control without heat stress-induced cracking. RTP aims to deliver superior membrane performance with less than 10 per cent of the fabrication time compared to normal slow calcination. The outcomes of this new technology aims to make inorganic membranes a commercial reality and maximize the membrane manufacturing capability and productivity of petrochemcial, chemical and clean coal/energy industries.Read moreRead less
Designing high performance gas separation by interfacial diffusion membrane. This project aims to develop a new generation of interfacial diffusion membranes for industrial gas separations including carbon dioxide removal, nitrogen gas enrichment, methane purification and air separation. The project focuses on advancing separation technologies for the petrochemical, natural gas, and clean energy industries in the mining sector. The project is expected to reveal new separation properties and perf ....Designing high performance gas separation by interfacial diffusion membrane. This project aims to develop a new generation of interfacial diffusion membranes for industrial gas separations including carbon dioxide removal, nitrogen gas enrichment, methane purification and air separation. The project focuses on advancing separation technologies for the petrochemical, natural gas, and clean energy industries in the mining sector. The project is expected to reveal new separation properties and performance based on highly selective interfacial diffusion membranes. The project will also create new scientific knowledge about the role of functional surfaces and nanostructures that will not only facilitate new membrane designs but also offer new, more cost-effective devices for solar conversion, energy storage and harvesting, biomedical applications, sensing and information technology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100661
Funder
Australian Research Council
Funding Amount
$426,551.00
Summary
Nanoparticle with Metal Organic Framework for Lithium Recovery from Brine. The project aims to develop technology enabling lithium to be cost-effectively extracted from brine. Today Australia meets the increasing demand for lithium by mining hardrock lithium, an environmentally damaging activity. An alternative is to source lithium from brine produced as industrial wastewater (in desalination or shale gas production). The main challenge that brine presents to selectively extracting lithium is co ....Nanoparticle with Metal Organic Framework for Lithium Recovery from Brine. The project aims to develop technology enabling lithium to be cost-effectively extracted from brine. Today Australia meets the increasing demand for lithium by mining hardrock lithium, an environmentally damaging activity. An alternative is to source lithium from brine produced as industrial wastewater (in desalination or shale gas production). The main challenge that brine presents to selectively extracting lithium is competing ions. By advancing knowledge of nanomaterials and membrane distillation, the project expects to overcome both this technical challenge and other practical challenges. From wastewater, the anticipated system will produce additional clean water and a valuable commodity that can offset the cost of water treatment. Read moreRead less