Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result ....Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result in an increase of the overall capacity and performance of engineering systems. This will contribute significantly to reductions in power consumption and improvements in productivity and work environment, leading ultimately to reductions in greenhouse gas emissions and to economic benefits.Read moreRead less
Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of ....Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of improved water quality models, and therefore to better management of water quality of Australia's water resources.Read moreRead less
Conjugate natural convection boundary layers. Conjugate natural convection systems occur when a conducting vertical wall separates fluids at different temperatures (that is at a window separating the interior of a room from the outside or when a container of fluid is placed in a refrigerator). This project will provide accurate predictions of such flows together with scaling relations.
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxyge ....Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxygen enrichment can augment scramjet thrust at high altitudes and speeds, and a performance evaluation of a launch system optimised for this approach. This could provide significant benefits to the performance of reusable, air-breathing launch technology, where Australia is leading the push towards commercialisation.Read moreRead less
Effect of Saline Water on Flotation Processes. The Australian mineral and coal industry is valued at $40 billion in export income per year. This significant component of the Australian economy will benefit from this research into the increased use of highly saline water to improve coal and mineral flotation recovery. The project will keep Australia at the leading edge of flotation research, research training and development for the coal and mineral industry. With direct relevance to the National ....Effect of Saline Water on Flotation Processes. The Australian mineral and coal industry is valued at $40 billion in export income per year. This significant component of the Australian economy will benefit from this research into the increased use of highly saline water to improve coal and mineral flotation recovery. The project will keep Australia at the leading edge of flotation research, research training and development for the coal and mineral industry. With direct relevance to the National Research Priorities: Water - a Critical Resource, this project will make contributions to the development of a more environmentally sustainable coal and mineral processing industry.Read moreRead less
Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a gr ....Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a greater understanding of how the nervous system functions. This knowledge will help in the design of new drugs to treat a variety of diseases and disorders. Essentially we will use a chemical armoury developed by the cone snail to design state-of-the-art mini-protein drugs.Read moreRead less
Structure and function of human zinc transporter membrane proteins. The aim of this project is to create fundamental new knowledge on how important mammalian membrane proteins operate. Membrane proteins are key drug targets and are significantly under-represented in structural databases. The project plans to combine innovative membrane protein screening technology with gene expression, structural biology, biophysics and cell biology. The project outcomes may elucidate specific molecular mechanis ....Structure and function of human zinc transporter membrane proteins. The aim of this project is to create fundamental new knowledge on how important mammalian membrane proteins operate. Membrane proteins are key drug targets and are significantly under-represented in structural databases. The project plans to combine innovative membrane protein screening technology with gene expression, structural biology, biophysics and cell biology. The project outcomes may elucidate specific molecular mechanisms underpinning the essential biological process of zinc homeostasis.Read moreRead less
Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less
Making peptides orally bioavailable. Bioactive peptides are exceptionally useful molecules, however to fully realise their exciting applications key limitations need to be overcome: they can't be delivered orally and they do not last long in the body. This project aims to develop a molecular tag that can dramatically enhance both the oral absorption and time in the body of a peptide. This will include identifying the key elements of the tag required for function, the breadth of peptide cargoes i ....Making peptides orally bioavailable. Bioactive peptides are exceptionally useful molecules, however to fully realise their exciting applications key limitations need to be overcome: they can't be delivered orally and they do not last long in the body. This project aims to develop a molecular tag that can dramatically enhance both the oral absorption and time in the body of a peptide. This will include identifying the key elements of the tag required for function, the breadth of peptide cargoes it can be applied to and the mechanisms underlying this technology. The outcomes of this project will facilitate the future development of peptides for biotechnology, pharmaceutical and veterinary applications.Read moreRead less