Understanding The Role Of The Putative Phospholipid Translocase ATP11c In B Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$455,153.00
Summary
The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.
Advanced materials for space propulsion: satellites and cubesats. Poorly controlled interactions between plasmas and surfaces often mean loss of process efficiency and surface degradation over time. For Hall thrusters, a type of engine used to move satellites in space, this means increased fuel consumption and shorter useful life. Through modelling and experiment, this project will show how intelligent selection of advanced materials and plasma parameters can minimise surface wear, enable in sit ....Advanced materials for space propulsion: satellites and cubesats. Poorly controlled interactions between plasmas and surfaces often mean loss of process efficiency and surface degradation over time. For Hall thrusters, a type of engine used to move satellites in space, this means increased fuel consumption and shorter useful life. Through modelling and experiment, this project will show how intelligent selection of advanced materials and plasma parameters can minimise surface wear, enable in situ material repair to extend device lifetime, and modulate plasma properties to increase thruster efficiency for a given task. These benefits enable reliable propulsion platforms for massive communication and observation satellite networks and deep space exploration.Read moreRead less
Towards a steady-state fusion reactor: understanding and controlling eruptive instabilities in tokamaks. The lifetime of future fusion reactors may be severely compromised by periodic releases of internal energy which can damage the reactor walls. In an international research effort that is based on unique Australian optical technologies, the project aims to resolve some of the key issues that should allow these instabilities to be suppressed.
Disorder as a novel determinant of photosynthetic structure and function: an experimental study. Australia enjoys a world reputation in photosynthesis research, typified by hosting the 2001 International Photosynthesis Congress. It also has a claim to fame for theoretical work in non-equilibrium thermodynamics concerning production of disorder or entropy, yielding new insights into planetary climates. This experimental project investigates the novel relation between entropy/entropy production ....Disorder as a novel determinant of photosynthetic structure and function: an experimental study. Australia enjoys a world reputation in photosynthesis research, typified by hosting the 2001 International Photosynthesis Congress. It also has a claim to fame for theoretical work in non-equilibrium thermodynamics concerning production of disorder or entropy, yielding new insights into planetary climates. This experimental project investigates the novel relation between entropy/entropy production and the structure/function of the solar powerhouse of plants (chloroplasts), and addresses fundamental questions at the interface of biology and physics. The research explores chloroplasts as a manifestation of the all-pervading Second Law of Thermodynamics, advancing Australia's contribution to basic science and helping to train researchers.Read moreRead less
Understanding helium induced nanostructure formation. This project addresses the interaction dynamics of high-flux helium particles with materials that drives surface nanowire growth. These dynamics are important to nuclear reactor materials and to developing new nanotechnology materials for high energy density lithium-ion battery anodes and water splitting catalysts. Through model and experiment, this project expects to generate new knowledge of processes that drive sub-surface nano-bubble form ....Understanding helium induced nanostructure formation. This project addresses the interaction dynamics of high-flux helium particles with materials that drives surface nanowire growth. These dynamics are important to nuclear reactor materials and to developing new nanotechnology materials for high energy density lithium-ion battery anodes and water splitting catalysts. Through model and experiment, this project expects to generate new knowledge of processes that drive sub-surface nano-bubble formation and surface nanowire growth in materials exposed to helium particles. This project will result in improved understanding of material degradation during nuclear reactor operation and will make a new contribution to high-value manufacturing capabilities for next generation energy systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100021
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A diagnostics platform for advanced plasma-chemical analysis. A wide range of production processes involve the use of plasmas to modify materials, but they are not well understood. This project will give Australian researchers the tools to look inside plasma processes and fully characterise them for the first time, unlocking new knowledge and providing new insight into the plasma processing environment.
Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The stud ....Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The study of this transport process will be important for understanding disorders like epilepsy and other disorders affecting neuronal excitability.Read moreRead less
Development of nanoporous materials for capture and release of oxygen. This project aims to develop new materials to make lighter, more efficient oxygen concentrators. The project will combine materials that can capture oxygen with particles that can be magnetically heated, making it possible to release the oxygen rapidly and efficiently when needed. Expected outcomes from this project include new composite materials and better understanding of how gases are trapped and released within composite ....Development of nanoporous materials for capture and release of oxygen. This project aims to develop new materials to make lighter, more efficient oxygen concentrators. The project will combine materials that can capture oxygen with particles that can be magnetically heated, making it possible to release the oxygen rapidly and efficiently when needed. Expected outcomes from this project include new composite materials and better understanding of how gases are trapped and released within composite materials. Benefits from this project may include oxygen concentrators that are more portable and have longer battery life, both with industrial and medical applications.Read moreRead less
Molecular analysis of photosynthetically-linked, active CO2 uptake and CO2 signal transduction by cyanobacteria (blue-green algae). Cyanobacteria (blue-green algae) have evolved a very efficient means of capturing and concentrating CO2 for photosynthetic fixation into sugars, the basic building blocks for cell growth. This process is dependent on the operation of several unique, active uptake systems for CO2 and HCO3-, with their genetic expression regulated by CO2 supply. This proposal will cap ....Molecular analysis of photosynthetically-linked, active CO2 uptake and CO2 signal transduction by cyanobacteria (blue-green algae). Cyanobacteria (blue-green algae) have evolved a very efficient means of capturing and concentrating CO2 for photosynthetic fixation into sugars, the basic building blocks for cell growth. This process is dependent on the operation of several unique, active uptake systems for CO2 and HCO3-, with their genetic expression regulated by CO2 supply. This proposal will capitalize on our progress in describing the functional genetics of this process and aims to elucidate the mechanism of active CO2 uptake and the way that cells sense the ambient CO2 concentration. The information gained is likely to be useful for designing improved crops.Read moreRead less
Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cell ....Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cells to remove material that is analysed at the atomic and molecular level. Ion beams are produced from plasma sources, but much of their operation is not understood. Such improved ion beams are expected to enable inexpensive and fast cellular level pathology at even small hospitals to tackle cancer for society’s benefit.Read moreRead less