From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100009
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Research Hub for Energy-efficient Separation. The ARC Research Hub for Energy-efficient Separation aims to develop advanced separation materials, innovative products and smart processes to reduce the energy consumption of separation processes. The Research Hub will create a multi-disciplinary training platform, supplying a highly-trained workforce for the advanced manufacturing sector, particularly in separation technology–a growth area in which Australia can lead the world. The advancement ....ARC Research Hub for Energy-efficient Separation. The ARC Research Hub for Energy-efficient Separation aims to develop advanced separation materials, innovative products and smart processes to reduce the energy consumption of separation processes. The Research Hub will create a multi-disciplinary training platform, supplying a highly-trained workforce for the advanced manufacturing sector, particularly in separation technology–a growth area in which Australia can lead the world. The advancement of Australia’s capability as a world-leading technology provider in manufacturing advanced separation materials and equipment will enable Australian industry to become more energy-efficient and cost-competitive in a global economy.Read moreRead less
Function and evolution of insect odorant receptors. This project aims to shed light on how insect odorant receptors function by using comparative genomic studies between the genetic model insect Drosophila melanogaster and a pest species, the Australian sheep blowfly. This project expects to generate knowledge of how specific chemicals activate specific receptors in order to excite sensory neurons and drive behaviour, which is not well understood. Expected outcomes include increased understandin ....Function and evolution of insect odorant receptors. This project aims to shed light on how insect odorant receptors function by using comparative genomic studies between the genetic model insect Drosophila melanogaster and a pest species, the Australian sheep blowfly. This project expects to generate knowledge of how specific chemicals activate specific receptors in order to excite sensory neurons and drive behaviour, which is not well understood. Expected outcomes include increased understanding of olfaction in insects, increased national and international collaboration, and outstanding graduate student training. This research will be of significant future benefit in deriving methods to modify the behaviour of insects of agricultural or medical importance, for example the sheep blowfly. Read moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.
Modelling with data: Advancing STEM in the primary curriculum. Improving the nation's skills in Science, Technology, Engineering, and Mathematics (STEM) remains a continuing concern, especially given the decline in international test results. The project aims to introduce a new approach to promoting this learning across grades 3-6 through modelling with data. With a focus on inquiry processes involving data variation and uncertainty within STEM-based contexts, the project aims to develop the imp ....Modelling with data: Advancing STEM in the primary curriculum. Improving the nation's skills in Science, Technology, Engineering, and Mathematics (STEM) remains a continuing concern, especially given the decline in international test results. The project aims to introduce a new approach to promoting this learning across grades 3-6 through modelling with data. With a focus on inquiry processes involving data variation and uncertainty within STEM-based contexts, the project aims to develop the important mathematical and statistical literacies needed for lifting student achievements. In advancing both theory and practice, the project aims to contribute to knowledge of primary students' capabilities for STEM problem solving and ways of enhancing implementation of the Australian Curriculum.Read moreRead less
Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on ....Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on young students' achievement in mathematics and further understanding of the relationship between talk and learning. These outcomes will inform policy and teacher education and have a long lasting impact on low SES students' educational and work opportunities with ultimate impact on economic and cultural prosperity.
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The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Developing molecular and physiological markers for marker-assisted barley breeding for waterlogging tolerance. The overall loss in crop production due to waterlogging is second largest after drought, and more than 5 million hectares in Australia are prone to waterlogging. This project will develop physiological and molecular markers allowing for the development of waterlogging tolerant crops, thus contributing to the National Goal of ‘Responding to Climate Change and Variability’.