Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Optimising dissolved air flotation (DAF) for algae removal by bubble modification in drinking water and advanced wastewater systems. Algal blooms in potable water reservoirs and advanced wastewater treatment lagoons can impact the performance and economic viability of water treatment processes resulting in taste and odour episodes and the risk of algal toxins as well as causing further limitation to already stressed water resources in Australia. This project aims to develop an adaptation of the ....Optimising dissolved air flotation (DAF) for algae removal by bubble modification in drinking water and advanced wastewater systems. Algal blooms in potable water reservoirs and advanced wastewater treatment lagoons can impact the performance and economic viability of water treatment processes resulting in taste and odour episodes and the risk of algal toxins as well as causing further limitation to already stressed water resources in Australia. This project aims to develop an adaptation of the dissolved air flotation process that is already used for algae treatment that will provide a more robust, economic and sustainable barrier to algal cells in accordance with the Australian Drinking and Recycled Water Guidelines.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and socia ....Working longer, staying healthy and keeping productive. Working longer, staying healthy and keeping productive. This project aims to develop a policy suite to respond to an older workforce. By 2060, nearly half of Australians aged 64 or older will be employed. Failure to address their health problems could threaten Australia’s economy, tax base and provision of health and care services. This collaboration between national policy portfolios (employment, social services, workplace health and social equity) and expert scientists in work, health, social equality and policy process intends to reveal the diversity of older workers’ work-health dilemmas and effective ways for national policies to solve them. The policy suite will promote financial independence and meet social goals of equity and healthy ageing.Read moreRead less
Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a gr ....Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a greater understanding of how the nervous system functions. This knowledge will help in the design of new drugs to treat a variety of diseases and disorders. Essentially we will use a chemical armoury developed by the cone snail to design state-of-the-art mini-protein drugs.Read moreRead less
Celebrate. Remember. Fight Back. Episodic Volunteering for Non-Profits. This project seeks to improve the policy and practice of volunteer involvement in the non-profit sector. Non-profit organisations rely on volunteers, and their capacity to deliver vital community services is threatened by the decrease in long-term, continuous volunteering and increase in episodic (short-term, flexible) volunteering. The interdisciplinary project aims to use mixed methods (qualitative interviews and quantitat ....Celebrate. Remember. Fight Back. Episodic Volunteering for Non-Profits. This project seeks to improve the policy and practice of volunteer involvement in the non-profit sector. Non-profit organisations rely on volunteers, and their capacity to deliver vital community services is threatened by the decrease in long-term, continuous volunteering and increase in episodic (short-term, flexible) volunteering. The interdisciplinary project aims to use mixed methods (qualitative interviews and quantitative surveys) and multiple perspectives (volunteers and staff who manage them) to develop an episodic volunteering definition; to explore the economic and social impact of episodic volunteering, and to develop a theoretical model of volunteer retention. The findings are intended to provide an evidence base and recommendations for non-profit sector policy and practice.Read moreRead less
ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorabl ....ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorable properties. The outcomes will include leading-edge science, the development of human capital, and intellectual property in new materials and products for applications in clean energy, environmental, and health care industries.Read moreRead less
Enabling engagement and inclusion: organisational factors that embed active support in accommodation services for people with intellectual disability. The study will investigate the processes and structures necessary to ensure frontline staff deliver high quality support to people with intellectual disability, which enables them to engage in meaningful activity. This knowledge will inform disability service organisation processes and provide indicators of structures necessary for effective servi ....Enabling engagement and inclusion: organisational factors that embed active support in accommodation services for people with intellectual disability. The study will investigate the processes and structures necessary to ensure frontline staff deliver high quality support to people with intellectual disability, which enables them to engage in meaningful activity. This knowledge will inform disability service organisation processes and provide indicators of structures necessary for effective services.Read moreRead less
Interaction Mining for Cyberbullying Detection on Social Networks. This project plans to build an interactive mining system to detect cyberbullying on social networks that have a large number of participants and a variety of inputs, including conversation texts, time-variant changes and user profiles. The project is designed to change the existing cyberbullying prevention services from reactive keyword filtering to proactive social interaction pattern mining. The intended outcome will enable the ....Interaction Mining for Cyberbullying Detection on Social Networks. This project plans to build an interactive mining system to detect cyberbullying on social networks that have a large number of participants and a variety of inputs, including conversation texts, time-variant changes and user profiles. The project is designed to change the existing cyberbullying prevention services from reactive keyword filtering to proactive social interaction pattern mining. The intended outcome will enable the early detection and warning of cyberbullying and approach open a new way to discover interaction patterns with a large number of participants over evolving and complex social networks.Read moreRead less
Lost in Transition: supporting young people with complex support needs. This project seeks to improve the lives of young people with complex support needs who experience overlapping forms of disadvantage. It intends to investigate how best to support their frequent transitions between services, institutions and care environments. These transitions are particularly problematic for this group, and if poorly supported, have significant social and economic costs. The project aims to analyse early li ....Lost in Transition: supporting young people with complex support needs. This project seeks to improve the lives of young people with complex support needs who experience overlapping forms of disadvantage. It intends to investigate how best to support their frequent transitions between services, institutions and care environments. These transitions are particularly problematic for this group, and if poorly supported, have significant social and economic costs. The project aims to analyse early life transitions and the supports available and to suggest best practice for transition support and a framework for how to track transitions using existing data. Intended outcomes will inform policy and practice in how best to invest in supports for young people with complex needs as they make multiple transitions.Read moreRead less