Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiol ....Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiology and molecular biology we expect to answer a fundamental question how STIM and Orai proteins interact to form functional store-operated calcium channels, and how the expression of STIM and Orai is regulated.Read moreRead less
Molecular dynamics of steroid receptor crosstalk. This project uses state-of-the-art technology to show how steroids (for example, testosterone) affect many aspects of human life, and how these can be disrupted by chemicals and synthetic hormones. The results can be used to interpret disease, predict safety of new drugs, and to monitor risk to humans and wildlife of environmental chemicals.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100234
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Enhancement of South Australian high-performance computing facilities. These facilities will enable the efficient use of high-performance computing and will more than double the capability provided by eResearch SA for South Australian researchers. They will support large-scale applications, running over many processors in parallel (high-performance computing) or large numbers of single processors (high-throughput computing).