Molecular & Neuropsychological Predictive Markers Of Cognitive Decline.
Funder
National Health and Medical Research Council
Funding Amount
$429,500.00
Summary
Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken wit ....Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken with several of these now in phase 2 clinical trials. However for these treatments to be most effective early diagnosis is crucial. Currently, definite diagnosis is restricted to post-mortem examination of the brain for the presence of characteristic neuropathological features. This project proposes to identify individuals at high risk of developing cognitive decline leading to AD by using a battery of biochemical, genetic and neuropsychological markers. This study builds on our earlier work which followed a cohort of memory complainers and demonstrated that subjects in this group have lower cognitive scores and an increased frequency of the genetic risk factor, the e4 allele of apolipoprotein E. Follow up of this well studied cohort with more sensitive and extensive neuropsychological tests together with other genetic and biochemical markers will be important in identifying those risk factors that have positive predictive value for cognitive decline thereby contributing towards enhancing the therapeutic efficacy of current symptomatic and future drugs directed at the cause of AD.Read moreRead less
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Predicting Health And Disease In Australian Men Over The Age Of 80 Years - The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$528,754.00
Summary
Australia is ageing rapidly but we still do not know whether the risk factors, such as health and lifestyle, that predict ill health in middle aged people, apply to people as they reach old age. This study of a large group of older men will examine the type and level of risk factors that apply to men aged beyond 75 years. It will not only determine rates of disability and mortality but also health service outcomes, including hospitalisation, and residential and community care usage.
Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account ....Integrating Models of Memory for Serial Order. This research aims to compare and integrate computational models of memory for serial order. The applicants have independently developed theoretically novel models, and this collaboration will enable them to combine and strengthen their complementary perspectives.
Much psychologically important processing, for example speech perception and spelling, requires the representation and reproduction of serial order information. Existing models account for a wide range of data and collectively represent exciting progress in the understanding of basic mechanisms of memory. Can these models be unified and reconciled? To date, detailed comparisons of models are lacking. This proposal is for the applicants to elaborate and unify their contrasting theoretical approaches.
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The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, ....The role of time and similarity in short-term memory. The project examines the role of time and similarity in memory for serial order, with the long-term goal to construct a new computational model of short-term memory. The investigators are internationally known for their models, and the collaboration will enable them to combine their complementary perspectives into a unifying theory. Theory construction will be guided by two sets of studies: The first will delineate the circumstances, if any, under which temporal separation at encoding affects memory. So far, we have shown that temporal distinctiveness has no effect on memory, unless people use temporal gaps to 'chunk' the list. The second set of studies will examine whether phonological similarity determines the strength of encoding.Read moreRead less
Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. Th ....Uncovering the processes underlying human category learning. There is a pervasive belief that complex tasks can somehow be learned via a 'smart' implicit or procedural learning mechanism, which operates independently of memory and attention. This idea has important implications for our understanding of cognition. If true, there seems little point in providing explicit instruction in such tasks, and efforts to do so are, at best, wasted time and, at worst, detrimental to the learning process. This project will provide much-needed scrutiny of this idea and will help not only to re-orient our understanding of how we deal with complex information, but will also highlight issues about data interpretation that are fundamental for the research and wider communities.Read moreRead less
Binding in working memory. Cross-modal binding?the integration of verbal and spatial features of events?is central to human cognition. However, it has been neglected in the study of working memory, where the dominant theoretical framework includes separate subsystems for the retention of verbal and spatial information. Using novel paradigms involving the concurrent auditory presentation of verbal and spatial information, the proposed research is directed at discovering (1) the fundamental chara ....Binding in working memory. Cross-modal binding?the integration of verbal and spatial features of events?is central to human cognition. However, it has been neglected in the study of working memory, where the dominant theoretical framework includes separate subsystems for the retention of verbal and spatial information. Using novel paradigms involving the concurrent auditory presentation of verbal and spatial information, the proposed research is directed at discovering (1) the fundamental characteristics of binding, and (2) the extent to which benchmark effects previously identified with a particular modality are ?inherited? by the other modality under conditions conducive to binding. Outcomes of the research will provide important constraints on the development of theories of working memory. In addition, the research will develop paradigms that have potentially important applications to clinical psychology, where diverse forms of psychopathology have been linked to deficits in binding.Read moreRead less
Time and Updating of Memory. What could be simpler than reading a few items, such as the digits in a phone number, and recalling them in the right order a short while later? Notwithstanding its apparent simplicity, this short-term serial recall task underlies sophisticated language abilities such as vocabulary acquisition and utterance production. Similarly, serial retention can be a critical element in mental arithmetic. A better understanding of short-term memory for serial order therefore has ....Time and Updating of Memory. What could be simpler than reading a few items, such as the digits in a phone number, and recalling them in the right order a short while later? Notwithstanding its apparent simplicity, this short-term serial recall task underlies sophisticated language abilities such as vocabulary acquisition and utterance production. Similarly, serial retention can be a critical element in mental arithmetic. A better understanding of short-term memory for serial order therefore has wide implications across many areas of education, in particular in primary school settings. The community benefit of this project arises from the improved teaching methods that can be developed on the basis of these results.Read moreRead less