Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882219
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Infrastructure for an integrated cognitive neurophysiological research facility: Mapping the neurobiology of memory and language. The Integrated Cognitive Neurophysiological Research Facility will enhance Australia's national research capacity in cognitive neuroscience by enabling large numbers of researchers and graduate students to investigate the neuroscience of memory and language in a collaborative, multi-disciplinary research environment. The facility will deliver national benefits by unco ....Infrastructure for an integrated cognitive neurophysiological research facility: Mapping the neurobiology of memory and language. The Integrated Cognitive Neurophysiological Research Facility will enhance Australia's national research capacity in cognitive neuroscience by enabling large numbers of researchers and graduate students to investigate the neuroscience of memory and language in a collaborative, multi-disciplinary research environment. The facility will deliver national benefits by uncovering the ways in which areas of the brain are used to remember events and process language. This information can then be used to understand how damage to the brain (such as in stroke or disease) can disrupt memory and language and subsequently lead to more effective neurorehabilitation techniques.Read moreRead less
Ageing and self-regulation. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. Our preliminary research suggests that self-regulation may be a significant problem for older Australians. The proposed research will provide a clearer picture of when and why older adults have difficulties regulating their behaviour, and which older adults are particularly susceptible to lapses in self-control. If older adults do hav ....Ageing and self-regulation. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. Our preliminary research suggests that self-regulation may be a significant problem for older Australians. The proposed research will provide a clearer picture of when and why older adults have difficulties regulating their behaviour, and which older adults are particularly susceptible to lapses in self-control. If older adults do have difficulties self-regulating, and if these self-regulation failures incur health, financial and social costs, by gaining a clearer understanding of this problem, the proposed research will take an important step in improving the lives of older Australians. Read moreRead less
Everyday cognition in older adulthood: Mechanisms contributing to the age-prospective memory paradox. Australia is faced with an ageing population, and thus an increasingly important goal is ageing well and ageing productively. The proposed research will clarify why older adults perform extremely well on prospective memory (PM) tasks based in everyday environments, but very poorly on PM tasks that take place in the controlled situation of the laboratory. Advancing our understanding of why this ....Everyday cognition in older adulthood: Mechanisms contributing to the age-prospective memory paradox. Australia is faced with an ageing population, and thus an increasingly important goal is ageing well and ageing productively. The proposed research will clarify why older adults perform extremely well on prospective memory (PM) tasks based in everyday environments, but very poorly on PM tasks that take place in the controlled situation of the laboratory. Advancing our understanding of why this 'paradoxical' pattern of age effects occurs will help clarify how other aspects of everyday cognition in older adulthood may be optimised, and consequently take an important step in improving the lives of older adults. The results will also inform development of rehabilitation strategies for clinical groups who present with PM difficulties. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Ageing, Inhibition, and Social Control - steps towards improving the lives of older adults. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. The proposed research will extend our preliminary findings on ageing and social inappropriateness to provide a clearer picture of when and why this occurs, and among whom. The proposed research will also examine the mental and physical health consequences of social inappro ....Ageing, Inhibition, and Social Control - steps towards improving the lives of older adults. Australia is faced with an ageing population, and thus an increasingly important national goal is ageing well and ageing productively. The proposed research will extend our preliminary findings on ageing and social inappropriateness to provide a clearer picture of when and why this occurs, and among whom. The proposed research will also examine the mental and physical health consequences of social inappropriateness longitudinally. If cognitive losses do lead to social losses, with attendant negative health consequences, by gaining a clearer understanding of this problem, the proposed research will take an important step in improving the lives of older adults.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Development of Advanced Wear Debris Analysis Techniques for Osteoarthritis Study. Wear and tear of joints is the common cause of osteoarthritis, costing $19.25 billion/year. With this cost on the increase, and no cure to date, comes a need to develop effective methods for its diagnosis. This study will provide new knowledge on osteoarthritis progression by allowing strategic use of national health resources. A fuzzy expert system, to be developed utilising the diagnostic/prognostic techniques of ....Development of Advanced Wear Debris Analysis Techniques for Osteoarthritis Study. Wear and tear of joints is the common cause of osteoarthritis, costing $19.25 billion/year. With this cost on the increase, and no cure to date, comes a need to develop effective methods for its diagnosis. This study will provide new knowledge on osteoarthritis progression by allowing strategic use of national health resources. A fuzzy expert system, to be developed utilising the diagnostic/prognostic techniques of this study will significantly reduce cost and time. The project will contribute to the National Strategy by helping older Australians; the major group of osteoarthritis sufferers, to retain their health, independence and productivity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102857
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Innovative chemical tools for the isolation, biochemical and structural analysis of biological macromolecular assemblies. This project will develop a new approach for determining the three dimensional structures of protein complexes. This project will demonstrate this approach by determining the structure of a protein complex involved in gene regulation and disease.
Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less