Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to tho ....Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to those cues. These results have the potential to revolutionise our understanding and treatment of child anxiety.Read moreRead less
The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of ....A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of considerable benefits for the community as improved theories of the nature and causes of delusions generate strategies for earlier detection or even prevention of the development of delusions, new methods of therapy for patients, and better understanding for families.Read moreRead less
Hypnosis and Emotional Numbing. Emotional numbing, or lack of emotional response, is a core problem in many clinical disorders. This project represents an innovative approach by using hypnosis to model emotional numbing in the laboratory and to investigate the mechanisms and effects of emotional numbing under experimental conditions. These studies will shed new light on the major factors that contribute to this form of emotional disorder, will lead to a new model of emotional numbing, and will ....Hypnosis and Emotional Numbing. Emotional numbing, or lack of emotional response, is a core problem in many clinical disorders. This project represents an innovative approach by using hypnosis to model emotional numbing in the laboratory and to investigate the mechanisms and effects of emotional numbing under experimental conditions. These studies will shed new light on the major factors that contribute to this form of emotional disorder, will lead to a new model of emotional numbing, and will have significant implications for our understanding and management of disordered emotional states.Read moreRead less
Cognitive neuropsychiatry: understanding delusional belief and delusional hallucination from a cognitive neuropsychological perspective. Cognitive neuropsychiatry aims to explain psychiatric symptoms in terms of abnormalities in the functioning of the human mind. This project applies a two-factor model of this type to better understand delusion and hallucination. In this model, a distinction is drawn between factors which explain the initial generation of an abnormal thought and factors which ex ....Cognitive neuropsychiatry: understanding delusional belief and delusional hallucination from a cognitive neuropsychological perspective. Cognitive neuropsychiatry aims to explain psychiatric symptoms in terms of abnormalities in the functioning of the human mind. This project applies a two-factor model of this type to better understand delusion and hallucination. In this model, a distinction is drawn between factors which explain the initial generation of an abnormal thought and factors which explain the uncritical acceptance, rather than rejection, of the abnormal thought. The generality of this model will be evaluated by investigating delusions in a range of clinical contexts. Findings may contribute to the design of more effective cognitive-behaviour therapies for treating psychosis in different clinical conditions.Read moreRead less
Disinhibition in Attention-deficit Hyperactivity Disorder: A behavioural and psychophysiological investigation. This project will provide much-needed information about optimal workload rates and effort levels, and the influence of external expectations, for those with ADHD, with immediate implications in remediation and educational settings. It will inform subsequent applied research, leading to better diagnosis and treatment, resulting in better societal outcomes for those with ADHD. Long-term ....Disinhibition in Attention-deficit Hyperactivity Disorder: A behavioural and psychophysiological investigation. This project will provide much-needed information about optimal workload rates and effort levels, and the influence of external expectations, for those with ADHD, with immediate implications in remediation and educational settings. It will inform subsequent applied research, leading to better diagnosis and treatment, resulting in better societal outcomes for those with ADHD. Long-term outcomes may reduce the significant financial burden placed on families and the Australian government and taxpayer by the increased use of hospital services and higher medical costs for children with ADHD, significantly increasing the likelihood of a healthy start to life for those directly, and indirectly, effected.Read moreRead less
Towards a model of emotional control: Assessment of patients with focal cortical injuries. This project will produce vital information about a potential mechanism that may underlie the observed association between frontal brain damage and deficits in emotional control. The proposed research will therefore have significant clinical and theoretical implications; it will enable better prediction of emotional dysregulation following brain injury, generation of more accurate models of emotional regul ....Towards a model of emotional control: Assessment of patients with focal cortical injuries. This project will produce vital information about a potential mechanism that may underlie the observed association between frontal brain damage and deficits in emotional control. The proposed research will therefore have significant clinical and theoretical implications; it will enable better prediction of emotional dysregulation following brain injury, generation of more accurate models of emotional regulation, as well as informing the provision and delivery of evidence-based treatments for emotional dysregulation. It will also contribute to our understanding of emotional functioning in other disorders characterized by frontal dysfunction, such as schizophrenia, depression and traumatic brain injury.
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Knowing in advance: Effective strategies for preparing young children for novel experiences. To optimise cognitive and emotional development, it is critical to identify the influences on children's lives. How parent-child conversations about the past shape development is well understood, but scant research has examined how adult-child preparatory discussions influence children's experience and memory of future events. Our research addresses this gap. It has important implications in medical, edu ....Knowing in advance: Effective strategies for preparing young children for novel experiences. To optimise cognitive and emotional development, it is critical to identify the influences on children's lives. How parent-child conversations about the past shape development is well understood, but scant research has examined how adult-child preparatory discussions influence children's experience and memory of future events. Our research addresses this gap. It has important implications in medical, educational, and other contexts in which it is vital to ensure that information given in advance increases children's understanding of an experience. More generally, in specifying optimal parent-child interactions, the findings are also relevant to interventions aiming to enhance psychological and emotional resilience in the early years. Read moreRead less
The contribution of early sensory cortex to working memory. This project examines how initial sensory areas of cerebral cortex contribute to working memory. We expect to find that the memory of a stimulus involves multiple representations held for different durations by different cortical areas. We will examine how these memorial representations are related to the known neuronal representations that are supported by each sensory cortical area. These findings will advance our understanding of how ....The contribution of early sensory cortex to working memory. This project examines how initial sensory areas of cerebral cortex contribute to working memory. We expect to find that the memory of a stimulus involves multiple representations held for different durations by different cortical areas. We will examine how these memorial representations are related to the known neuronal representations that are supported by each sensory cortical area. These findings will advance our understanding of how perceptual memories are organised and represented in the brain. They will also challenge the traditional view that segregates memory from perception by showing that certain memories are inseparable from the sensory structures mediating their content.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560916
Funder
Australian Research Council
Funding Amount
$323,400.00
Summary
Magnetic resonance in humans: Equipment for neuroscience studies. The structure, function and biochemistry of the human brain can now be assessed non-invasively using magnetic resonance (MR) techniques. A 3 Tesla MR facility with half its time available for research has recently been established at POWMRI. This application seeks state-of-the-art equipment so that the facility can optimise its research potential and enhance its scientific output. Research is directed to understanding how the nor ....Magnetic resonance in humans: Equipment for neuroscience studies. The structure, function and biochemistry of the human brain can now be assessed non-invasively using magnetic resonance (MR) techniques. A 3 Tesla MR facility with half its time available for research has recently been established at POWMRI. This application seeks state-of-the-art equipment so that the facility can optimise its research potential and enhance its scientific output. Research is directed to understanding how the normal brain functions, how deficits in function develop, and how the function and structure of the brain change with age. This grant will help establish an internationally-competitive, broadly-based facility which is dedicated to understanding the human brain.Read moreRead less