Action-related learning and plasticity in the cortico-striatal network. This project focuses on the neural bases of adaptive behaviour, specifically on the neural processes through which new actions are acquired. This project aims to establish the neural networks involved as well as the locus of the critical cellular plasticity mediating this learning process in the brain.
Attentional and conditioning mechanisms that mediate overcoming anxiety. Anxiety is a common emotion for most Australians that can cause substantial costs for individuals and society. This project uses dominant psychological models to identify critical mechanisms that are believed to predict capacity for, and change in, anxiety. Outcomes substantially advance knowledge about how humans overcome anxiety.
Discovery Early Career Researcher Award - Grant ID: DE140100588
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered gl ....Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understanding of the potential approaches that could be used to improve cognitive function.Read moreRead less
Multiscale and multimodal modelling of brain dynamics. This project aims to understand dynamics of how several brain regions work together to process information. This project will generate new knowledge in brain sciences by using state of the art computational modelling and neuroimaging methods like functional and diffusion magnetic resonance imaging and electromagnetic measurements. This project will develop technologies to compute multiscale, multimodal and directed connectivity in the brain. ....Multiscale and multimodal modelling of brain dynamics. This project aims to understand dynamics of how several brain regions work together to process information. This project will generate new knowledge in brain sciences by using state of the art computational modelling and neuroimaging methods like functional and diffusion magnetic resonance imaging and electromagnetic measurements. This project will develop technologies to compute multiscale, multimodal and directed connectivity in the brain. Expected outcomes of this project will enhance our understanding of the brain’s functional organization and dynamics. The benefits of this project will include breakthroughs in development of new neuro-technologies like brain-machine interfaces and neuroscience inspired artificial intelligence. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100128
Funder
Australian Research Council
Funding Amount
$395,000.00
Summary
Information processing in the brain. This project aims to understand the brain's functional organisation by developing non-invasive methods to characterise connectivity between interacting brain regions. No model-based methods to compute directional coupling between brain regions can be applied to large scale networks for resting state functional MRI data. This capability would be a major breakthrough in neuroimaging, given uninformative (non-directional) network connectivity analysis restricts ....Information processing in the brain. This project aims to understand the brain's functional organisation by developing non-invasive methods to characterise connectivity between interacting brain regions. No model-based methods to compute directional coupling between brain regions can be applied to large scale networks for resting state functional MRI data. This capability would be a major breakthrough in neuroimaging, given uninformative (non-directional) network connectivity analysis restricts research. This project is expected to advance our understanding of information processing in the brain by providing a mechanistic approach to functional integration.Read moreRead less
Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelli ....Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelling approaches to benefit reward processing algorithms for learning behaviours in humans or artificial intelligence. This project will fuel the understanding of algorithms driving social media platforms and consumer consumption, hence driving economic and technological progress in Australia.Read moreRead less
Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe ....Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe how these connections are recruited during learning and memory, and then to test their function experimentally. The outcomes will extend the known neural circuitry that controls learning by defining how and where these unexplored pathways fit within it; thus advancing knowledge regarding neural regulation of behaviour.
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Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less
Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding o ....Australian Heritage: constructing the first Aboriginal reference genome. This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding of global human genomic variants and provide a range of new targets relevant to medical biology, while significantly improving our knowledge of human genetic history and its consequences in the modern day.Read moreRead less
The genomic landscape of speciation in hominins and other taxa. This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways a ....The genomic landscape of speciation in hominins and other taxa. This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways are central to the speciation process. The framework will be developed using the large genomic datasets available across a range of plant and animal species. Applying the model to a modern human population dataset will elucidate the role introgressed DNA from Denisovan and Neanderthals has played in shaping human evolutionary history and may provide novel insights into the genetic basis of disease.Read moreRead less