News media are highly influential in setting health agendas and shaping health policy. The program builds multidisciplinary research capacity between 3 universities, including participation by some of Australia’s leading health journalists, to examine the content and accuracy of news treatments of health issues, how key audiences understand and are influenced by news coverage, how journalists decide which issues to cover and how they approach this coverage. The program aims to improve media lite ....News media are highly influential in setting health agendas and shaping health policy. The program builds multidisciplinary research capacity between 3 universities, including participation by some of Australia’s leading health journalists, to examine the content and accuracy of news treatments of health issues, how key audiences understand and are influenced by news coverage, how journalists decide which issues to cover and how they approach this coverage. The program aims to improve media literacy and the potency of policy advocacy among health professionals and so improve the quality of health news reporting in Australia.Read moreRead less
Estrogen - A Potential New Treatment For Women & Men With Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$227,545.00
Summary
Estrogen - the major female hormone, has been shown in animal studies to decrease the two main brain chemicals (dopamine and serotonin) that are implicated in causing schizophrenia. The effect of estrogen in the brain is similar to current antipsychotic drugs. We have carried out a study that showed that when we gave 12 young women with schizophrenia 100 micrograms of estrogen in a skin patch form plus standard antipsychotic drug treament they recovered more quickly than 12 young women who recei ....Estrogen - the major female hormone, has been shown in animal studies to decrease the two main brain chemicals (dopamine and serotonin) that are implicated in causing schizophrenia. The effect of estrogen in the brain is similar to current antipsychotic drugs. We have carried out a study that showed that when we gave 12 young women with schizophrenia 100 micrograms of estrogen in a skin patch form plus standard antipsychotic drug treament they recovered more quickly than 12 young women who received standard antipsychotic drug treatment only. 100mcg is a safe dose of estrogen. In this proposal we want to expand and clarify the pilot study resutls by conducting a 28 day trial in a total of 60 women with schizophrenia. 30 women would receive 100 mcg skin patch estrogen plus antipsychotic medication and 30 women would receive antipsychotic medicationly only. We also tested the value of adding a very small dose of oral estrogen to antipsychotic drug treatment in five men with schizophrenia and found that they made a better recovery compared to five men who received standard antipsychotic drugs only. We trialled the use of estrogen for seven days in men, but this may not have been long enough to examine the real impact of estrogen treatment in men. In this proposal we want to conduct a 14 day trial in a total of 60 men with schizophrenia. 30 men would receive 2mg of oral estrogen plus antipsychotic drug treatment and their results would be compared with 30 men who received standard antipsychotic drug treatment plus a placebo tablet identical in appearance to estrogen. For 14 days, this low dose of estrogen is very safe. Potentially estrogen may be a useful addition to the current standard treatment of schizophrenia. It may decrease the duration of acute illness and in women it may have a role in preventing relapses of schizophrenia as well as improving the general health of women with schizophrenia.Read moreRead less
Randomised Controlled Trial Of Aripiprazole For Treatment Of Auditory Verbal Hallucinations In Borderline Personality Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,748,148.00
Summary
People with borderline personality disorder (BPD) often report hearing voices. There is no consensus about how to treat these symptoms. Our study aims to address this clinical problem by conducting a 12 week trial of antipsychotic medication in patients who hear voices and have a diagnosis of BPD. The study will examine the effect of this medication on the nature of these voices, as well as other aspects of mental illness and brain functioning. The results will directly inform clinical practice.
I am a lab-based neurochemist-cell biologist with expertise in protein chemistry and pharmacology. My research focuses on the dynamin family of proteins in the endocytosis of synaptic vesicles and in the molecular mechanisms of synaptic transmission in th
Ecstasy use is growing faster throughout the world than than any other drug of abuse. United Nations figures from 2003 show that it is used by more individuals than the combined total of cocaine and heroin users. Australia has the highest per capita use of 'Ecstasy' in the world with rates twice those of North Americal and Europe. As a result of this we also have a high rate of adverse effects. These can be immediate, and lead to death, or long term leading to brain damage and psychopathologies. ....Ecstasy use is growing faster throughout the world than than any other drug of abuse. United Nations figures from 2003 show that it is used by more individuals than the combined total of cocaine and heroin users. Australia has the highest per capita use of 'Ecstasy' in the world with rates twice those of North Americal and Europe. As a result of this we also have a high rate of adverse effects. These can be immediate, and lead to death, or long term leading to brain damage and psychopathologies. So far, no studies have been conducted,anywhere in the world, which have objectively examined the medical effects of 'ecstasy' in the dance clubs where it is used. Because of this, there is a lot of speculation on whether the animal based or hospital based studies are valid and relate to normal recreational use of this drug. This has led to a degree of suspicion by users and health professionals as to the medical problems claimed to be associated with the drug. This project extends a pilot study we undertook which has highlighted that in a recreational setting it is likely that specific individuals are susceptible to damage by 'ecstasy'. The purpose of this project is to examine this in detail, and identify who, and why some young persons are at risk of immediate life threatening outcomes from 'ecstasy' use or may develop brain damage later. The intended outcome is to provide clear evidence of adverse effects and why they occur. This evidence may be used to improve harm minimisation and treatment programs.Read moreRead less
How Commonly Used Psychoactive Drugs Affect The Hypothalamo-pituitary-adrenal Axis
Funder
National Health and Medical Research Council
Funding Amount
$411,448.00
Summary
The body makes a number of responses when it is subjected to stress, and these include the secretion of hormones from the adrenal gland, including cortisol. It is not surprising that cortisol has effects upon the way the brain operates, nor is it surprising that diseases that are associated with stress (e.g. depression, alcoholism and other psychiatric complaints) create abnormal cortisol secretion. The drugs that are known to be successful in treating conditions such as depression and anxiety h ....The body makes a number of responses when it is subjected to stress, and these include the secretion of hormones from the adrenal gland, including cortisol. It is not surprising that cortisol has effects upon the way the brain operates, nor is it surprising that diseases that are associated with stress (e.g. depression, alcoholism and other psychiatric complaints) create abnormal cortisol secretion. The drugs that are known to be successful in treating conditions such as depression and anxiety have been shown to affect the secretion of cortisol, but, somewhat paradoxically, we do not precisely know how they operate. The aim of this research is to examine how drugs that are commonly used for the treatment of a number of psychiatric conditions (e.g. Prozac, Tofranil, Xanax, morphine and naltrexone) affect the secretion of hormones from the brain that ulitmately regulate the secretion of cortisol. We propose that the effects of these drugs is related to how they operate, and for how long they have been given. The findings generated by this research may help us determine new ways of diagnosing and treating a range of conditions.Read moreRead less
Emotion Regulation in Posttraumatic Stress Disorder. Posttraumatic Stress Disorder (PTSD) can affect 7-12% of Australians in their lifetime. It is a chronic disorder with enormous personal, social and economic costs. In the current climate of increasing mass violence and natural disaster, the health burden of PTSD is expected to rise. This project will help us identify core processes and mechanisms involved in PTSD, and help us to develop more effective and specialized treatments. It will al ....Emotion Regulation in Posttraumatic Stress Disorder. Posttraumatic Stress Disorder (PTSD) can affect 7-12% of Australians in their lifetime. It is a chronic disorder with enormous personal, social and economic costs. In the current climate of increasing mass violence and natural disaster, the health burden of PTSD is expected to rise. This project will help us identify core processes and mechanisms involved in PTSD, and help us to develop more effective and specialized treatments. It will also extend our understanding of how the brain inhibits emotion, which has wider relevance for many anxiety disorders in terms of their development and prevention.Read moreRead less
Rumination and Memory Functioning in Depression. By investigating and identifying the cognitive processes underlying symptom maintenance, this research will advance cognitive conceptualisations of depression. The findings will result in the generation and empirical evaluation of psychological treatment procedures for depression by taking a strong science-practitioner approach, ultimately enhancing: (i) the efficacy and cost effectiveness of psychological treatments for depressive disorders, and ....Rumination and Memory Functioning in Depression. By investigating and identifying the cognitive processes underlying symptom maintenance, this research will advance cognitive conceptualisations of depression. The findings will result in the generation and empirical evaluation of psychological treatment procedures for depression by taking a strong science-practitioner approach, ultimately enhancing: (i) the efficacy and cost effectiveness of psychological treatments for depressive disorders, and (ii) the provision of mental health services to the Australian community. In applying rigorous experimental methodologies to answer theoretically driven questions about depression maintenance, these studies represent the interface of empirically sound and clinically-oriented experimental research.Read moreRead less
Building resilience in Aceh. The poor health, academic, and mental health functioning of Acehnese people is one of the major public health problems in the Asian Pacific region. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce mental health problems in Acehnese communities. This project directly addresses the priority of safeguarding Australia by establishing an empirical platform ....Building resilience in Aceh. The poor health, academic, and mental health functioning of Acehnese people is one of the major public health problems in the Asian Pacific region. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce mental health problems in Acehnese communities. This project directly addresses the priority of safeguarding Australia by establishing an empirical platform to shape future policies for enhancing the social and emotional well-being of one of Australia's important northern neighbours.Read moreRead less