Understanding Early Life Risk Factors For Inflammation In The Rising Predisposition For NCDs
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
In 2011 the UN General Assembly identified the rise in non-communicable diseases (NCDs) as a major global threat, and prioritized preventive strategies against diseases like obesity, diabetes, heart disease, allergy and asthma. Common risk factors for these inflammatory diseases begin early in life, the most logical time for prevention. Our international interdisciplinary network aims to improve health and prevent NCDs by early interventions that reduce inflammation over the life-course.
Atrial fibrillation is the most common heart rhythm disturbance with a prevalence of approximately 1% but which increases markedly with age. It causes debilitating symptoms, heart failure, stroke and increased mortality. It is an important determinant of neuro-cognitive decline and dementia. The studies in this proposal will help define the mechanism of this rhythm disturbance and its associated symptoms. They will help design improved treatment strategies including interventional approaches.