Short Term Effects Of Overfeeding On Metabolic Risk In Humans
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Obesity is associated with increased risk of diabetes, heart disease and cancer. Obesity prevalence is rapidly increasing and consitutes one of the greatest threats to human health. The aim of this study is to determine mechanism-s underlying the close relationship between obesity and insulin resistance by inducing experimental weight gain in humans with and without a genetic predisposition to diabetes. This project will help identify new candidates for anti-diabetes drugs.
Long Term Progression And Pathways Of Cardiometabolic Risks For Mothers And Their Adult Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$453,605.00
Summary
The aim of this research is to investigate long term postnatal outcomes of cardiovascular diseases and mortality throughout the female reproductive life course and beyond, and to study the causes, progression and pathways of metabolic syndrome, diabetes, and obesity from birth to adulthood within adult males and females.
Nutritional Epidemiology Of Cardiometabolic Risk And Mental Health Disorders From Infancy To Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
I developed and am leading a program of nutrition research that is making a substantial difference and contribution to the literature that will eventually make a difference to the lives of children and adolescents. The focus of this work will be on the nutritional risk factors for mental health and development of the metabolic syndrome that includes cardiovascular and diabetes risk.
Pathophysiology And Therapeutics Of Lipoprotein Disorders In Humans
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Lipid disorder is the major casual factor that contributes to the development of cardiovascular disease, the leading cause of death in Australia. My research has provided new knowledge that has significant impact upon the treatment strategy of lipid disorder and cardiovascular risk. My vision for the next four years is to develop a comprehensive program in understanding lipid transport and translating the knowledge into clinical practice.
Elucidating The Molecular Regulation Of Gp130 Complex Signalling In Lipid And Glucose Metabolism.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Overnutrition promotes obesity, which greatly increases the risk of type 2 diabetes and cardiovascular disease. We have provided evidence that activation of gp130 signalling may enhance insulin action and fatty acid oxidation in metabolically active tissues. My research proposal aims to elucidate the molecular regulation of gp130 complex signalling in lipid and glucose metabolism in important metabolic tissues.