Boron and silicon based pincer ligands for environmentally responsible catalysis. The production of everyday chemicals (pharmaceuticals, agrochemicals, polymers) comes at a price, economic and environmental. Metal catalysts significantly reduce the environmental impact of both the associated energy requirements and waste products. New classes of catalysts will be developed based on the unconventional elements boron and silicon.
New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-relate ....New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-related analogues of natural compounds will be synthesised for biological evaluation.Read moreRead less
Non-urban water regulation: next generation compliance & enforcement . This project aims to develop the next generation of regulatory technology in non-urban water compliance and enforcement. Effective technologies are needed to make government regulation more efficient, reduce regulatory burdens and improve compliance with complex laws. This project delivers new ways to optimise regulatory technologies that drive innovation, reduce costs and enhance sustainable water use. Expected outcomes incl ....Non-urban water regulation: next generation compliance & enforcement . This project aims to develop the next generation of regulatory technology in non-urban water compliance and enforcement. Effective technologies are needed to make government regulation more efficient, reduce regulatory burdens and improve compliance with complex laws. This project delivers new ways to optimise regulatory technologies that drive innovation, reduce costs and enhance sustainable water use. Expected outcomes include regulatory guidance strategies and training, advances in applied regulatory theory, and innovative technology tools capturing the complexity of water regulation and supporting decision-making. This will provide public resource savings and ensure fairness and effectiveness of water compliance and enforcement.Read moreRead less
New Cascade Routes to Biologically Important Molecules. This research involves the development of short and efficient syntheses of several different classes of biologically active molecules using cascade reactions: spectacular events in which many chemical bonds are formed. Two distinct types of cascade reactions will be investigated and naturally-occurring molecules with antineoplastic, anti-immunosuppressive, antiviral and antimalarial activities will be prepared. These new, expedient routes a ....New Cascade Routes to Biologically Important Molecules. This research involves the development of short and efficient syntheses of several different classes of biologically active molecules using cascade reactions: spectacular events in which many chemical bonds are formed. Two distinct types of cascade reactions will be investigated and naturally-occurring molecules with antineoplastic, anti-immunosuppressive, antiviral and antimalarial activities will be prepared. These new, expedient routes allow the preparation of a wide range of structurally-related analogues; an important prerequisite for the preparation of libraries of compounds for biological evaluation. Along the way, important information about the chemical reactivity patterns of a newly-prepared, fundamental class of hydrocarbon molecules will be obtained.Read moreRead less
Biosphere, hydrocarbon and ore fluid interactions in the Early Precambrian. Ore deposits and petroleum are important for economic and social areas of Australia's growth. New discoveries are needed to maintain Australia's wealth as mines reach the end of operations and petroleum supplies decrease. This project will demonstrate how ore fluids and hydrocarbons interact in the geological environment. It should, therefore greatly expand the conceptual framework in which to explore for both mineral an ....Biosphere, hydrocarbon and ore fluid interactions in the Early Precambrian. Ore deposits and petroleum are important for economic and social areas of Australia's growth. New discoveries are needed to maintain Australia's wealth as mines reach the end of operations and petroleum supplies decrease. This project will demonstrate how ore fluids and hydrocarbons interact in the geological environment. It should, therefore greatly expand the conceptual framework in which to explore for both mineral and hydrocarbon resources, particularly in old, deep and hot basins, which are considered to be the last frontiers of exploration. Outcomes concerning the nature of early life will be of global interest.Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100016
Funder
Australian Research Council
Funding Amount
$2,959,803.00
Summary
ARC Research Hub to Advance Timber for Australia’s Future Built Environment. This project aims to transform Australia’s timber and construction sectors by stimulating rapid growth in timber innovation and uptake of use of timber in buildings. It plans to enable this transformation by addressing the diverse elements required to motivate investment, stimulate innovation, satisfy stakeholder demands, define long-term social-environmental-economic benefits and establish a roadmap for change. The exp ....ARC Research Hub to Advance Timber for Australia’s Future Built Environment. This project aims to transform Australia’s timber and construction sectors by stimulating rapid growth in timber innovation and uptake of use of timber in buildings. It plans to enable this transformation by addressing the diverse elements required to motivate investment, stimulate innovation, satisfy stakeholder demands, define long-term social-environmental-economic benefits and establish a roadmap for change. The expected outcomes will kickstart the change process, supported by growth in advanced manufacturing across the value chain. This should provide significant benefits in stimulating an opportunity for regional development and resource diversification whilst helping the sectors transition to a circular and net-zero economy.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at le ....Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at least, comparable ductility and corrosion resistance. Not only will the outcomes of the work be a fundamental advance to the fields of metallurgy and corrosion science, they will lead to the identification of an optimised compositional window for creating our second generation Mg-Li alloy family capable of being manufactured into ultra-lightweight, corrosion resistant metal products.Read moreRead less