The vision we rely on every day to read and recognise faces depends upon the health of the central portion of our retina, the macula. Age-related Macular Degeneration (AMD) is the leading cause of blindness in Australia and the western world. Researchers at the Australian National University are collaborating to bring a new test for AMD severity to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them manage treatment.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly r ....Researching the Social Role of Religions in Australia. Most Australians claim allegiance to various religions in the Census. The number of religious denominations has greatly increased in recent years, most notably through immigration, with significant numbers from all world religions. Political and social policies are frequently influenced by religious principles and a detailed analysis of this variety is of crucial national importance. Religions from neighbouring societies are significantly represented in Australia. Understanding them is of central importance in international political and commercial activity. Current research is essential, based on the most recent Census and other recent socio-economic information.
Read moreRead less
What makes for successful numeracy education in remote Indigenous contexts: an ethnographic case study approach. There are many successful teachers and schools who have enabled remote Indigenous learners to engage with, and learn, school mathematics. But what do they do? How do they do it? This project investigates and documents successful practices in 32 schools located in remote communities. The project includes the many aspects of teaching practice.
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Sing ....Processing mathematics tasks: the nature and role of visual and non-visual reasoning in digital and non-digital environments. Within the next four years, it is likely that the National Assessment Plan for Literacy and Numeracy (NAPLAN) will be administered in a digital mode. This project identifies differences between the delivery of mathematics assessment in pencil-and-paper and computer-based modes. Primary students' mathematics reasoning is compared across these modes and to cohorts from Singapore.Read moreRead less
Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when s ....Processing dynamic graphics: Visuospatial reasoning in mathematics. Increasingly, mathematics competence will be measured in digital and dynamic contexts. Students who possess high visuospatial reasoning are expected to become even better equipped to succeed in science, technology, engineering and mathematics (STEM) related disciplines as technological advances shape how we interpret and decode information. This project explores those aspects of visuospatial reasoning critical for success when students encounter dynamic mathematics tasks, and attempts to determine whether different forms of visuospatial reasoning are required to decode static and dynamic information. The project aims to better understand how students process mathematics tasks, so the inevitable move toward digital assessment can be managed effectively to promote assessment for learning.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Social and geographical location and its impact on mathematics teaching and learning. Too many students from poor urban backgrounds or from rural communities are at risk of underperforming in school mathematics. This project identifies the critical factors that contribute to this failure and seeks to develop improved practices to enable greater access to school mathematics.