How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying com ....How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying complex human brain functions remains to be elucidated. By combining transcriptome quantification and bioinformatics methods, this project will close an important knowledge gap in our understanding of transcriptional regulation underlying human brain function. This will provide benefits such as the potential to influence public health policy including in cognitive functions and aging.Read moreRead less
Dissecting cell cycle regulation using programmable gene editing technology. This program aims to harness the unprecedented power of CRISPR-Cas13 gene-editing technology to develop high-throughput tools to explore the role of RNA regulation in cell cycle control. This project expects to generate new knowledge about cell division and RNA biology by utilizing this new technology and applying interdisciplinary approaches. Expected outcomes of this proposal include new research tools capable of broa ....Dissecting cell cycle regulation using programmable gene editing technology. This program aims to harness the unprecedented power of CRISPR-Cas13 gene-editing technology to develop high-throughput tools to explore the role of RNA regulation in cell cycle control. This project expects to generate new knowledge about cell division and RNA biology by utilizing this new technology and applying interdisciplinary approaches. Expected outcomes of this proposal include new research tools capable of broadly addressing biological questions across multiple disciplines (e.g. from health to food production). This project intends to provide significant benefits, such as enhanced biological knowledge, multidisciplinary training opportunities and will build Australia’s capability in this rapidly expanding field.Read moreRead less
Dissecting endocardial signals required for cardiac muscle regeneration in zebrafish. Unlike humans, zebrafish have an extraordinary ability to regenerate their damaged hearts. This project will study the endocardium, a thin layer of cells lining the inner heart, to find important genes for regeneration. Results from this study may provide insights into proper repair of human hearts after injury.
RNA-based analysis for prediction of islet death in diabetes. Death of insulin-producing cells is a common feature in diabetes. Presently, a blood glucose test remains the only blunt instrument to diagnose diabetes. The RNA-based analysis for prediction of islet death in diabetes (RAPID) study links with eight clinical trials to test this newly developed non-invasive assay for predicting diabetes. Early diagnosis will help to reduce diabetic complications in later life.
Socio-spatial implications of smart city development in India. The project aims to generate extensive new knowledge on the complex socio-spatial implications of smart city development; and the ways in which they have been further consolidated, expedited, and elevated in response to COVID, and to stimulate the pandemic-hit economies. It makes a significant contribution to smart urbanism discourse globally with a focus on equity and its special role at times of crisis. The outcomes include a Smart ....Socio-spatial implications of smart city development in India. The project aims to generate extensive new knowledge on the complex socio-spatial implications of smart city development; and the ways in which they have been further consolidated, expedited, and elevated in response to COVID, and to stimulate the pandemic-hit economies. It makes a significant contribution to smart urbanism discourse globally with a focus on equity and its special role at times of crisis. The outcomes include a Smart City Roadmap for advising diverse stakeholders on how to negotiate for and build inclusive smart cities - with significant benefits in strengthening existing, and building new connections between India and Australia in an area of bilateral national significance.Read moreRead less
Exploring novel coding genomic features through integrative proteogenomics. Knowledge of the full extent to which the human genome is made into proteins is of fundamental importance in the study of health and disease. New technological advances are now enabling functional studies of genomes with increasing detail. This project aims to develop and apply cutting edge bioinformatics methods to perform an integrative and comprehensive exploration of the extent to which the genes of a human cell line ....Exploring novel coding genomic features through integrative proteogenomics. Knowledge of the full extent to which the human genome is made into proteins is of fundamental importance in the study of health and disease. New technological advances are now enabling functional studies of genomes with increasing detail. This project aims to develop and apply cutting edge bioinformatics methods to perform an integrative and comprehensive exploration of the extent to which the genes of a human cell line are made into proteins. The project will improve our understanding of the human genome and deliver cutting edge methodology applicable for genome annotation in all living organisms.Read moreRead less
The Spectral Theory and Harmonic Analysis of Geometric Differential Operators. The project will involve mathematical research of the highest international standard in two very active and far-reaching field of mathematics: quantum chaos, and harmonic analysis. Progress in these fields will have implications in areas such as communications technology (e.g. image compression), quantum theory, and mathematical analysis (e.g. partial differential equations).
Predictability in evolution: From behaviour to genome. This project aims to determine whether evolution is primarily unpredictable and stochastic, or predictable and constrained along certain pathways. By using a natural experiment that caused wood-feeding cockroaches to evolve into soil-burrowing cockroaches in response to climate change millions of years ago, this project will determine how the genomes of these organisms responded. This will show whether the same molecular changes are repeated ....Predictability in evolution: From behaviour to genome. This project aims to determine whether evolution is primarily unpredictable and stochastic, or predictable and constrained along certain pathways. By using a natural experiment that caused wood-feeding cockroaches to evolve into soil-burrowing cockroaches in response to climate change millions of years ago, this project will determine how the genomes of these organisms responded. This will show whether the same molecular changes are repeatedly used in the evolution of complex traits, including burrow construction. This will contribute to the understanding of how predictable evolution is at the molecular level, and provide insights into how genomes change in response to prolonged climate change.Read moreRead less
Operator algebras as models for dynamics and geometry. Operator algebra is the mathematical theory which describes quantum physics and predicts how quantum systems will behave. Through this project, the researcher's recent discoveries in operator algebra will give us new insight into the dynamics and geometry - that is, the behaviour and shape - of the quantum world.
City Living: Urban consolidation and the social sustainability of cities. This project will investigate the dynamic tensions that arise in cities between individual and communal rights and requirements through a detailed examination of the lived experiences of urban apartment residents and owners. It will provide ground-breaking data on the influence of socio-economic mix on the governance and management of apartment buildings, residents’ perceptions of home and the broader implications for the ....City Living: Urban consolidation and the social sustainability of cities. This project will investigate the dynamic tensions that arise in cities between individual and communal rights and requirements through a detailed examination of the lived experiences of urban apartment residents and owners. It will provide ground-breaking data on the influence of socio-economic mix on the governance and management of apartment buildings, residents’ perceptions of home and the broader implications for the social sustainability of cities and will further current academic debates on these issues. It will open new opportunities for inter-disciplinary and international collaboration and provide evidence to inform planning and urban development policy nationally and internationally.Read moreRead less