An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene reg ....An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene regulation that will help fill these knowledge gaps. This will provide a more comprehensive understanding of RNA-mediated gene regulation, and will open up new research opportunities to target RNA based gene regulatory complexes.Read moreRead less
Multi-hazard resilient hybrid modular structures. This project aims to develop the next generation of multi-hazard resilient modular construction methods for efficient, affordable and sustainable buildings. New demountable modular connections will be developed and the response of hybrid modular buildings to multiple hazards such as wind, earthquake, blast and impact will be investigated through a combination of experimental, numerical, and analytical studies. The project will develop knowledge o ....Multi-hazard resilient hybrid modular structures. This project aims to develop the next generation of multi-hazard resilient modular construction methods for efficient, affordable and sustainable buildings. New demountable modular connections will be developed and the response of hybrid modular buildings to multiple hazards such as wind, earthquake, blast and impact will be investigated through a combination of experimental, numerical, and analytical studies. The project will develop knowledge of the structural behaviour of hybrid modular buildings, and expects to deliver design methods and robust simplified models for building design purposes. This project will advance construction techniques and practices for resilient hybrid modular buildings.Read moreRead less
A southern hemisphere ground station for the Atomic Clock Ensemble in Space mission. Australia is aiming for membership in the high-profile space mission involving atomic clocks on-board the International Space Station. The mission will test aspects of special and general relativity, searching for tell-tale signs of new physics. This project will construct an atomic fountain clock and install a microwave-satellite link to meet the goal.
A multilevel approach to leadership and dynamic capabilities in organisations. The quality of leadership in Australian organisations has an impact on business productivity, international competitiveness, and employee health and well-being. This research will support the development of leadership skills at different organisational levels. For senior leaders, these skills include developing strategy, allocating resources, and supporting innovation. For team leaders, skills include team coordinatio ....A multilevel approach to leadership and dynamic capabilities in organisations. The quality of leadership in Australian organisations has an impact on business productivity, international competitiveness, and employee health and well-being. This research will support the development of leadership skills at different organisational levels. For senior leaders, these skills include developing strategy, allocating resources, and supporting innovation. For team leaders, skills include team coordination, employee support, and creating flexibility. By supporting interventions that build adaptivity and flexibility in organisations, the research will provide resources to support dynamic organisations to be better equipped to compete in demanding international markets.Read moreRead less
Innovative Data Driven Techniques for Structural Condition Monitoring . Safe and sustainable infrastructure involves the development and application of structural monitoring and assessment techniques for condition evaluation. This project develops an innovative structure condition monitoring approach based on the emerging digital technologies on image processing, data analytics and machine learning techniques, for better infrastructure asset management under operational environment. Expected out ....Innovative Data Driven Techniques for Structural Condition Monitoring . Safe and sustainable infrastructure involves the development and application of structural monitoring and assessment techniques for condition evaluation. This project develops an innovative structure condition monitoring approach based on the emerging digital technologies on image processing, data analytics and machine learning techniques, for better infrastructure asset management under operational environment. Expected outcomes of this project enhance the capacity to conduct the operational monitoring and data interpretation to deliver the best life cycle performance of infrastructure. This project should provide significant benefits to Australia in infrastructure asset management by reducing the interruption of infrastructure operations.Read moreRead less
Novel carbon dioxide tolerant ceramic membranes for oxygen separation to improve the viability of clean energy technology. Conventional cryogenic air separation is a major economic impediment to the deployment of these low emission technologies like Callide oxyfuel combustion. This project will lead to the discovery of a new class of oxygen selective membranes for air separation with significantly reduced cost to improve the viability of these clean energy technologies.
Advanced bio-inspired polymer assembly: tools for diagnostics, imaging and therapies. ‘Smart’ polymeric materials have the potential to make a significant impact in areas such as healthcare. However, to do this effectively the materials will need to respond intelligently to biological signals. This project will involve the synthesis and application of ‘smart’ polymer films and particles, which mimic biological behaviour.
Gelled electrolyte materials for toxic gas sensing. This project aims to develop and implement an alternative approach to the current methods of monitoring of oxygen and toxic gas levels. The aim is to use novel gelled electrolytes based on ionic liquids and polymers, combined with miniaturised sensor devices, to create a robust membrane-free and spill-less design. Amperometric gas sensors are commonly employed to monitor oxygen and toxic gas levels, but the technology used is still based on a ....Gelled electrolyte materials for toxic gas sensing. This project aims to develop and implement an alternative approach to the current methods of monitoring of oxygen and toxic gas levels. The aim is to use novel gelled electrolytes based on ionic liquids and polymers, combined with miniaturised sensor devices, to create a robust membrane-free and spill-less design. Amperometric gas sensors are commonly employed to monitor oxygen and toxic gas levels, but the technology used is still based on a 1950s design. The expected outcome of the project is to make fundamental advances in the design of materials that are not affected by humidity changes and which impart selectivity towards particular gases. This will provide the basis for a new generation of low-cost, miniaturised, selective sensors for use in applications such as wearable toxic gas sensors, and as leak detectors on hydrogen-powered vehicles.Read moreRead less
A Bayesian Approach to Distributed Estimation for Multi-Object Systems. This project aims to develop new signal processing techniques that facilitate autonomous technologies for environmental perception, with the ability to efficiently process large data volumes from multiple sensing modalities. Rapid advances in sensors and networks have led to a digital data deluge, from which extracting useful information presents new technological challenges and opportunities. To address this development, th ....A Bayesian Approach to Distributed Estimation for Multi-Object Systems. This project aims to develop new signal processing techniques that facilitate autonomous technologies for environmental perception, with the ability to efficiently process large data volumes from multiple sensing modalities. Rapid advances in sensors and networks have led to a digital data deluge, from which extracting useful information presents new technological challenges and opportunities. To address this development, this project seeks to develop new distributed solutions for statistical estimation, which are specifically designed for dynamic systems with multiple object states, and are inherently scalable and robust. The potential benefits include new technologies for smart cities, autonomous infrastructure, and digital productivity.Read moreRead less
Sliding diodes: harvesting triboelectricity with surface chemistry. This project aims to create new methods for the conversion of friction at vibrating metal–semiconductor contacts into a continuous source of electricity; an autonomous technology to power miniature electronics in applications spanning health management to environmental sensing. The expected outcomes of this project include the development of new surface chemistry and miniature semiconductor technologies, with benefits for the de ....Sliding diodes: harvesting triboelectricity with surface chemistry. This project aims to create new methods for the conversion of friction at vibrating metal–semiconductor contacts into a continuous source of electricity; an autonomous technology to power miniature electronics in applications spanning health management to environmental sensing. The expected outcomes of this project include the development of new surface chemistry and miniature semiconductor technologies, with benefits for the design and function of silicon-based devices such as life-critical pacemakers, and self-powered monitors in remote/dangerous places.Read moreRead less