Discovery Early Career Researcher Award - Grant ID: DE120102610
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The role of deep-sea microorganisms in nutrient cycling in the Southern Ocean. This project aims to learn how surface water microbes that are important in global nutrient cycling adapt to life when they sink to the deep sea. This will teach us about the roles that surface water and deep sea microbes play in maintaining the health of marine environments.
Discovery Early Career Researcher Award - Grant ID: DE150100009
Funder
Australian Research Council
Funding Amount
$389,476.00
Summary
Toxic Oceans: How do anthropogenic pollutants impact vital marine microbes? Environmental pollution threatens the sustainability of the world's oceans. However, we still do not understand how pollution affects primary producers at the base of oceanic food chains. This project aims to provide the first account of how common chemical pollutants (herbicides, plastic leachates and crude oil) affect key groups of marine photosynthetic bacteria. As these microbes underpin entire marine food webs, unde ....Toxic Oceans: How do anthropogenic pollutants impact vital marine microbes? Environmental pollution threatens the sustainability of the world's oceans. However, we still do not understand how pollution affects primary producers at the base of oceanic food chains. This project aims to provide the first account of how common chemical pollutants (herbicides, plastic leachates and crude oil) affect key groups of marine photosynthetic bacteria. As these microbes underpin entire marine food webs, understanding their responses is crucial to monitoring and mitigating the impact of pollutants on ocean ecosystems. The aim is to design and validate novel, rapid environmental stress assays, based on gene expression profiling. This represents a pioneering new application of gene monitoring techniques to ocean conservation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101563
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
The sweet road to synthesis of bacterial sugar structures. This project aims to characterise the synthesis pathways of nonulosonic acid sugars (NulOs) in bacteria using a combination of bioinformatics and experimental methodologies. Bacteria produce long chains of sugars or glycans on their cell surface known as capsules. These often contain important NulOs that can be uniquely harvested for use in the nutrition, cosmetic and bioremediation industries. By understanding the natural pathways of th ....The sweet road to synthesis of bacterial sugar structures. This project aims to characterise the synthesis pathways of nonulosonic acid sugars (NulOs) in bacteria using a combination of bioinformatics and experimental methodologies. Bacteria produce long chains of sugars or glycans on their cell surface known as capsules. These often contain important NulOs that can be uniquely harvested for use in the nutrition, cosmetic and bioremediation industries. By understanding the natural pathways of their synthesis, ‘glycans-by-design’ can be synthetically created with potent tailor-made properties. This project endeavours to examine how glycans with acidic sugars are produced to generate a fundamental understanding of sugar biology and create a database that will advance industrial applications in glycoengineering.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101524
Funder
Australian Research Council
Funding Amount
$355,325.00
Summary
Taking Control: Understanding regulation of bacterial iron acquisition. This project aims to uncover the bacterial regulatory networks acting on a family of iron-stealing molecules called siderophores. Bacteria use siderophores to acquire iron from their hosts, the environment, and each other – as such, they have a central role in microbial life. Despite their importance, we have an incomplete knowledge of how these iron-stealing weapons are deployed. This project will develop a new genomics-bas ....Taking Control: Understanding regulation of bacterial iron acquisition. This project aims to uncover the bacterial regulatory networks acting on a family of iron-stealing molecules called siderophores. Bacteria use siderophores to acquire iron from their hosts, the environment, and each other – as such, they have a central role in microbial life. Despite their importance, we have an incomplete knowledge of how these iron-stealing weapons are deployed. This project will develop a new genomics-based, high-throughput technology for defining bacterial gene regulation networks, and use it to understand siderophore control. This will provide new knowledge of siderophore function, enhance understanding of bacterial community and host interactions, and establish leadership in a new genomics technology in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101325
Funder
Australian Research Council
Funding Amount
$353,705.00
Summary
Opalised fossils and the evolution of Australia's dinosaurs. This project aims to study dinosaur evolution in Australia. Dinosaurs were one of Earth's most successful land vertebrates, but Australia’s perceived poor dinosaur fossil record has stymied significant advances in the field and promoted the view that it was an evolutionary dead-end. This project will challenge this perception by coupling an exceptional but under-valued fossil resource from Lightning Ridge, NSW, with new phylogenetic me ....Opalised fossils and the evolution of Australia's dinosaurs. This project aims to study dinosaur evolution in Australia. Dinosaurs were one of Earth's most successful land vertebrates, but Australia’s perceived poor dinosaur fossil record has stymied significant advances in the field and promoted the view that it was an evolutionary dead-end. This project will challenge this perception by coupling an exceptional but under-valued fossil resource from Lightning Ridge, NSW, with new phylogenetic methodology and synchrotron analyses. The expected result is better understanding of the diversity, biology, and evolutionary relationships of Australian dinosaurs in the context of global dinosaur evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100008
Funder
Australian Research Council
Funding Amount
$387,103.00
Summary
Exploring the evolution and ecology of non-photosynthetic Cyanobacteria. This project aims to contribute and expand our rudimentary understanding of non-photosynthetic Cyanobacteria by obtaining representative genome sequences using metagenomics. The dogma that all Cyanobacteria are photosynthetic has recently been challenged by the discovery of non-photosynthetic lineages. This project expects to obtain representative genome sequences using metagenomics to predict surface structures. The expect ....Exploring the evolution and ecology of non-photosynthetic Cyanobacteria. This project aims to contribute and expand our rudimentary understanding of non-photosynthetic Cyanobacteria by obtaining representative genome sequences using metagenomics. The dogma that all Cyanobacteria are photosynthetic has recently been challenged by the discovery of non-photosynthetic lineages. This project expects to obtain representative genome sequences using metagenomics to predict surface structures. The expected outcomes from this project includes providing insights into the function and evolution of non-photosynthetic Cyanobacteria and their viruses, and pure or enriched cultures to enable future studies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101222
Funder
Australian Research Council
Funding Amount
$392,132.00
Summary
Australia's key role in the evolution of songbirds. This project aims to provide novel insights into the evolutionary history of songbirds, which originated in Australia and now make up over half of the world's birds. The project will combine fossil, morphological, and genomic data to describe early songbird diversity in Australia, reconstruct the evolutionary relationships of fossil species, estimate the timescale of their diversification, and resolve the timing and nature of key evolutionary c ....Australia's key role in the evolution of songbirds. This project aims to provide novel insights into the evolutionary history of songbirds, which originated in Australia and now make up over half of the world's birds. The project will combine fossil, morphological, and genomic data to describe early songbird diversity in Australia, reconstruct the evolutionary relationships of fossil species, estimate the timescale of their diversification, and resolve the timing and nature of key evolutionary changes in songbirds. The project is expected to produce critical new fossil evidence and to strengthen international and multidisciplinary collaborations. Expected outcomes include significant advances in our understanding of a major component of the Australian and global fauna.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100929
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Stronger together: understanding antibiotic synergy on a molecular level. This project aims to use genomics-based approaches to answer fundamental questions about how antibiotic synergy works. Antibiotic combination therapy presents an opportunity to revive the use of antibiotics in otherwise resistant bacteria, yet currently there is little understanding of the molecular mechanisms underlying antibiotic synergy. Studies indicate that additional mechanisms of action (MOA) occur during synergist ....Stronger together: understanding antibiotic synergy on a molecular level. This project aims to use genomics-based approaches to answer fundamental questions about how antibiotic synergy works. Antibiotic combination therapy presents an opportunity to revive the use of antibiotics in otherwise resistant bacteria, yet currently there is little understanding of the molecular mechanisms underlying antibiotic synergy. Studies indicate that additional mechanisms of action (MOA) occur during synergistic killing beyond those of the original antibiotics. This project will identify genes involved in multiple synergistic treatments and determine how bacterial cells gain resistance. The synergy-specific MOA identified also represent an untapped reservoir of primary drug targets.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101053
Funder
Australian Research Council
Funding Amount
$421,656.00
Summary
Archaeal vesicles: new insights into viral evolution and DNA transfer. This project aims to determine the basis for plasmid and membrane vesicle generation and DNA transfer at the cellular and molecular level. Recent discovery of plasmid vesicles, which transfer plasmid DNA between host cells using viral capsid-like membrane vesicles, suggests they may be an evolutionary precursor for virus particles. The expected project outcomes include the first substantive characterisation of membrane vesicl ....Archaeal vesicles: new insights into viral evolution and DNA transfer. This project aims to determine the basis for plasmid and membrane vesicle generation and DNA transfer at the cellular and molecular level. Recent discovery of plasmid vesicles, which transfer plasmid DNA between host cells using viral capsid-like membrane vesicles, suggests they may be an evolutionary precursor for virus particles. The expected project outcomes include the first substantive characterisation of membrane vesicles in the phylum Euryarchaeota, how plasmid vesicles are generated and transmitted, and new insights into how viruses may evolve. This may lead to new avenues for preventing viral transmission and supporting development of new and improved applications biotechnology and the safe delivery of vaccines or genes in animals and humans.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100373
Funder
Australian Research Council
Funding Amount
$447,320.00
Summary
The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expec ....The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expects to generate new knowledge at the forefront of research into diversity maintenance, ecosystem functioning and higher-order interactions. The outcomes should provide a deep mechanistic understanding of microbial community dynamics, with applications from animal health to environmental flows and insect pest management.Read moreRead less